Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/22623
Título: | Protein disulphide isomerase-assisted functionalization of proteinaceous substrates |
Autor(es): | Fernandes, Margarida M. Paulo, Artur Cavaco |
Palavras-chave: | Protein disulphide isomerase (PDI) Ribonuclease A (RNase A) Keratin fibres Biotechnology Cosmetics |
Data: | 2012 |
Editora: | Informa Healthcare |
Revista: | Biocatalysis and Biotransformation |
Resumo(s): | Protein disulphide isomerase (PDI) is an enzyme that catalyzes thiol-disulphide exchange reactions among a broad spectrum of substrates, including proteins and low-molecular thiols and disulphides. As the first protein-folding catalyst reported, the study of PDI has mainly involved the correct folding of several cysteine-containing proteins. Its application on the functionalization of protein-based materials has not been extensively reported. Herein, we review the applications of PDI on the modification of proteinaceous substrates and discuss its future potential. The mechanism involved in PDI functionalization of fibrous protein substrates is discussed in detail. These approaches allow innovative applications in textile dyeing and finishing, medical textiles, controlled drug delivery systems and hair or skin care products. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/22623 |
DOI: | 10.3109/10242422.2012.646657 |
ISSN: | 1024-2422 1029-2446 |
Versão da editora: | http://dx.doi.org/10.3109/10242422.2012.646657 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | DET/2C2T - Artigos em revistas internacionais com arbitragem científica |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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2012 Protein disulphide isomerase-assisted functionalization of proteinaceous substrates.pdf | Protein disulphide isomerase-assisted functionalization of proteinaceous substrates | 957,64 kB | Adobe PDF | Ver/Abrir |