Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/33452
Título: | Genetic variants and multiple myeloma risk : IMMEnSE validation of the best reported associations : an extensive replication of the associations from the Candidate gene era |
Autor(es): | Martino, Alessandro Campa, Daniele Jurczyszyn, Artur Martínez-Lopez, Joaquín Moreno, Maria José Varkonyi, Judit Dumontet, Charles García-Sanz, Ramón Gemignani, Federica Jamroziak, Krzysztof Stepien, Anna Jacobsen, Svend E. Hove Andersen, Vibeke Jurado, Manuel Landi, Stefano Rossi, Anna Maria Lesueur, Fabienne Marques, Herlander Dudzinski, Marek Watek, Marzena Moreno, Victor Orciuolo, Enrico Petrini, Mario Reis, R. M. Ríos, Rafael Sainz, Juan Vogel, Ulla Buda, Gabriele Vangsted, Annette Juul Canzian, Federico |
Data: | Abr-2014 |
Editora: | American Association for Cancer Research |
Revista: | Cancer Epidemiology, Biomarkers & Prevention |
Resumo(s): | BACKGROUND: Genetic background plays a role in multiple myeloma susceptibility. Several single-nucleotide polymorphisms (SNP) associated with genetic susceptibility to multiple myeloma were identified in the last years, but only a few of them were validated in independent studies. METHODS: With the aim to conclusively validate the strongest associations so far reported, we selected the polymorphisms rs2227667 (SERPINE1), rs17501108 (HGF), rs3136685 (CCR7), rs16944 (IL1B), rs12147254 (TRAF3), rs1805087 (MTR), rs1800629 (TNF-a), rs7516435 (CASP9), rs1042265 (BAX), rs2234922 (mEH), and rs1801133 (MTHFR). We genotyped them in 1,498 multiple myeloma cases and 1,934 controls ascertained in the context of the International Multiple Myeloma rESEarch (IMMEnSE) consortium, and meta-analyzed our results with previously published ones. RESULTS: None of the selected SNPs were significantly associated with multiple myeloma risk (P value range, 0.055-0.981), possibly with the exception of the SNP rs2227667 (SERPINE1) in women. CONCLUSIONS: We can exclude that the selected polymorphisms are major multiple myeloma risk factors. IMPACT: Independent validation studies are crucial to identify true genetic risk factors. Our large-scale study clarifies the role of previously published polymorphisms in multiple myeloma risk. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/33452 |
DOI: | 10.1158/1055-9965.EPI-13-1115 |
ISSN: | 1055-9965 |
Versão da editora: | http://cebp.aacrjournals.org/content/early/2014/02/12/1055-9965.EPI-13-1115.abstract |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
martino a_canc epid biom prev 2014.pdf Acesso restrito! | 179,22 kB | Adobe PDF | Ver/Abrir |