Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/38103
Título: | Design of controlled release systems for THEDES - therapeutic deep eutectic solvents, using supercritical fluid technology |
Autor(es): | Aroso, Ivo Manuel Ascensão Craveiro, Rita Rocha, Ângelo Dionisio, Madalena Barreiros, Susana Reis, R. L. Paiva, Alexandre Duarte, Ana Rita C. |
Palavras-chave: | Biodegradable polymers Drug delivery systems Ibuprofen Supercritical carbon dioxide Therapeutic deep eutectic solvents |
Data: | Ago-2015 |
Editora: | Elsevier |
Revista: | International Journal of Pharmaceutics |
Citação: | Aroso I. M., Craveiro R., Rocha A., Dionisio M., Barreiros S., Reis R. L., Paiva A., Duarte A. R. C. Design of controlled release systems for THEDES - therapeutic deep eutectic solvents, using supercritical fluid technology, International Journal of Pharmaceutics, Vol. 492, Issue 1-2, pp. 73-79, doi:10.1016/j.ijpharm.2015.06.038, 2015 |
Resumo(s): | Deep eutectic solvents (DES) can be formed by bioactive compounds or pharmaceutical ingredients. A therapeutic DES (THEDES) based on ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), and menthol was synthesized and its thermal behavior was analyzed by differential scanning calorimetry (DSC). A controlled drug delivery system was developed by impregnating a starch:poly-ϵ-caprolactone polymeric blend (SPCL 30:70) with the menthol:ibuprofen THEDES in different ratios (10 and 20 wt%), after supercritical fluid sintering at 20 MPa and 50 °C. The morphological characterization of SPCL matrices impregnated with THEDES was performed by scanning electron microscopy (SEM) and micro-computed tomography (micro-CT). Drug release studies were carried out in a phosphate buffered saline. The results obtained provide important clues for the development of carriers for the sustainable delivery of bioactive compounds. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/38103 |
DOI: | 10.1016/j.ijpharm.2015.06.038 |
ISSN: | 0378-5173 |
Versão da editora: | http://www.sciencedirect.com/science/article/pii/S0378517315300053 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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18473-SPCL THEDES_Int J Pharm 2015.pdf | 1,46 MB | Adobe PDF | Ver/Abrir |