Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/49806
Título: | Canonical sonic Hedgehog signaling in early lung development |
Autor(es): | Silva, Hugo Miguel Fernandes Correia-Pinto, Jorge Moura, Rute S. |
Palavras-chave: | Sonic Hedgehog (SHH) Lung development Endoderm specification Branching morphogenesis Signaling Transcriptional regulation |
Data: | 27-Mar-2017 |
Editora: | MDPI Publishing |
Revista: | Journal of Developmental Biology |
Citação: | Fernandes-Silva, H., Correia-Pinto, J., & Moura, R. S. (2017). Canonical sonic hedgehog signaling in early lung development. Journal of Developmental Biology, 5(1), 3 |
Resumo(s): | The canonical hedgehog (HH) signaling pathway is of major importance during embryonic development. HH is a key regulatory morphogen of numerous cellular processes, namely, cell growth and survival, differentiation, migration, and tissue polarity. Overall, it is able to trigger tissue-specific responses that, ultimately, contribute to the formation of a fully functional organism. Of all three HH proteins, Sonic Hedgehog (SHH) plays an essential role during lung development. In fact, abnormal levels of this secreted protein lead to severe foregut defects and lung hypoplasia. Canonical SHH signal transduction relies on the presence of transmembrane receptors, such as Patched1 and Smoothened, accessory proteins, as Hedgehog-interacting protein 1, and intracellular effector proteins, like GLI transcription factors. Altogether, this complex signaling machinery contributes to conveying SHH response. Pulmonary morphogenesis is deeply dependent on SHH and on its molecular interactions with other signaling pathways. In this review, the role of SHH in early stages of lung development, specifically in lung specification, primary bud formation, and branching morphogenesis is thoroughly reviewed. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/49806 |
DOI: | 10.3390/jdb5010003 |
ISSN: | 2221-3759 |
Versão da editora: | http://www.mdpi.com/2221-3759/5/1/3/html |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |