Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/62380
Título: | Discovery of key whole-brain transitions and dynamics during human wakefulness and non-REM sleep |
Autor(es): | Stevner, A. B. A. Vidaurre, D. Cabral, Joana Rapuano, K. Nielsen, S. F. V. Tagliazucchi, E. Laufs, H. Vuust, P. Deco, G. Woolrich, M. W. Van Someren, E. Kringelbach, M. L. |
Palavras-chave: | Adult Brain Brain Mapping Electroencephalography Female Humans Magnetic Resonance Imaging Male Nerve Net Neural Pathways Neuroimaging Sensitivity and Specificity Sleep Stages Sleep, REM Time Factors Wakefulness Young Adult |
Data: | 2019 |
Editora: | Nature Research |
Revista: | Nature Communications |
Citação: | Stevner, A. B. A., Vidaurre, D. I. E. G. O., Cabral, J., et. al. (2019). Discovery of key whole-brain transitions and dynamics during human wakefulness and non-REM sleep. Nature communications, 10(1), 1035. |
Resumo(s): | The modern understanding of sleep is based on the classification of sleep into stages defined by their electroencephalography (EEG) signatures, but the underlying brain dynamics remain unclear. Here we aimed to move significantly beyond the current state-of-the-art description of sleep, and in particular to characterise the spatiotemporal complexity of whole-brain networks and state transitions during sleep. In order to obtain the most unbiased estimate of how whole-brain network states evolve through the human sleep cycle, we used a Markovian data-driven analysis of continuous neuroimaging data from 57 healthy participants falling asleep during simultaneous functional magnetic resonance imaging (fMRI) and EEG. This Hidden Markov Model (HMM) facilitated discovery of the dynamic choreography between different whole-brain networks across the wake-non-REM sleep cycle. Notably, our results reveal key trajectories to switch within and between EEG-based sleep stages, while highlighting the heterogeneities of stage N1 sleep and wakefulness before and after sleep. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/62380 |
DOI: | 10.1038/s41467-019-08934-3 |
ISSN: | 2041-1723 |
e-ISSN: | 2041-1723 |
Versão da editora: | https://www.nature.com/articles/s41467-019-08934-3 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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s41467-019-08934-3.pdf | 5,51 MB | Adobe PDF | Ver/Abrir |