Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/73443
Título: | Bolaamphiphilic Bis-Dehydropeptide hydrogels as potential drug release systems |
Autor(es): | Amorim, Carolina Veloso, Sérgio Rafael Silva Castanheira, Elisabete M. S. Hilliou, L. Pereira, Renato B. Pereira, David M. Martins, J. A. Jervis, Peter John Ferreira, Paula M. T. |
Palavras-chave: | Hydrogels Nanoencapsulation Drug delivery Bola-amphiphiles dehydropeptide self-assembly supramolecular hydrogels |
Data: | 29-Abr-2021 |
Editora: | Multidisciplinary Digital Publishing Institute (MDPI) |
Revista: | Gels |
Citação: | Amorim, C., Veloso, S. R., Castanheira, E., Hilliou, L., Pereira, R. B., et. al (2021). Bolaamphiphilic bis-dehydropeptide hydrogels as potential drug release systems. Gels, 7(2), 52 |
Resumo(s): | The self-assembly of nanometric structures from molecular building blocks is an effective way to make new functional materials for biological and technological applications. In this work, four symmetrical bolaamphiphiles based on dehydrodipeptides (phenylalanyldehydrophenylalanine and tyrosyldehydrophenylalanine) linked through phenyl or naphthyl linkers (terephthalic acid and 2,6-naphthalenedicarboxylic acid) were prepared, and their self-assembly properties were studied. The results showed that all compounds, with the exception of the bolaamphiphile of tyrosyldehydrophenylalanine and 2,6-naphthalene dicarboxylic acid, gave self-standing hydrogels with critical gelation concentrations of 0.3 wt % and 0.4 wt %, using a pH trigger. The self-assembly of these hydrogelators was investigated using STEM microscopy, which revealed a network of entangled fibers. According to rheology, the dehydrodipeptide bolaamphiphilic hydrogelators are viscoelastic materials with an elastic modulus G' that falls in the range of native tissue (0.37 kPa brain-4.5 kPa cartilage). In viability and proliferation studies, it was found that these compounds were non-toxic toward the human keratinocyte cell line, HaCaT. In sustained release assays, we studied the effects of the charge present on model drug compounds on the rate of cargo release from the hydrogel networks. Methylene blue (MB), methyl orange (MO), and ciprofloxacin were chosen as cationic, anionic, and overall neutral cargo, respectively. These studies have shown that the hydrogels provide a sustained release of methyl orange and ciprofloxacin, while methylene blue is retained by the hydrogel network. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/73443 |
DOI: | 10.3390/gels7020052 |
e-ISSN: | 2310-2861 |
Versão da editora: | https://www.mdpi.com/2310-2861/7/2/52 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | PHYSICS OF QUANTUM MATERIALS AND BIONANOSTRUCTURES (2018 - ...) IPC - Artigos em revistas científicas internacionais com arbitragem |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
gels2021.pdf | Main Document | 5,07 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons