A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)
- Author
- Konstantinos J Mavrakis, Joni Van der Meulen (UGent) , Andrew L Wolfe, Xiaoping Liu, Evelien Mets (UGent) , Tom Taghon (UGent) , Aly A Khan, Manu Setty, Pieter Rondou (UGent) , Peter Vandenberghe, Eric Delabesse, Yves Benoit, Nicholas B Socci, Christina S Leslie, Pieter Van Vlierberghe (UGent) , Franki Speleman (UGent) and Hans-Guido Wendel
- Organization
- Abstract
- The importance of individual microRNAs (miRNAs) has been established in specific cancers. However, a comprehensive analysis of the contribution of miRNAs to the pathogenesis of any specific cancer is lacking. Here we show that in T-cell acute lymphoblastic leukemia (T-ALL), a small set of miRNAs is responsible for the cooperative suppression of several tumor suppressor genes. Cross-comparison of miRNA expression profiles in human T-ALL with the results of an unbiased miRNA library screen allowed us to identify five miRNAs (miR-19b, miR-20a, miR-26a, miR-92 and miR-223) that are capable of promoting T-ALL development in a mouse model and which account for the majority of miRNA expression in human T-ALL. Moreover, these miRNAs produce overlapping and cooperative effects on tumor suppressor genes implicated in the pathogenesis of T-ALL, including IKAROS (also known as IKZF1), PTEN, BIM, PHF6, NF1 and FBXW7. Thus, a comprehensive and unbiased analysis of miRNA action in T-ALL reveals a striking pattern of miRNA-tumor suppressor gene.
- Keywords
- LEUKEMOGENESIS, RNA, IKAROS, TARGETS, MICE, MUTATIONS, EXPRESSION, NOTCH1, HUMAN CANCERS, C-MYC, T-ALL, leukemia, miRNA, microRNA, cancer
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-2051743
- MLA
- Mavrakis, Konstantinos J., et al. “A Cooperative MicroRNA-Tumor Suppressor Gene Network in Acute T-Cell Lymphoblastic Leukemia (T-ALL).” NATURE GENETICS, vol. 43, no. 7, 2011, pp. 673–78, doi:10.1038/ng.858.
- APA
- Mavrakis, K. J., Van der Meulen, J., Wolfe, A. L., Liu, X., Mets, E., Taghon, T., … Wendel, H.-G. (2011). A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL). NATURE GENETICS, 43(7), 673–678. https://doi.org/10.1038/ng.858
- Chicago author-date
- Mavrakis, Konstantinos J, Joni Van der Meulen, Andrew L Wolfe, Xiaoping Liu, Evelien Mets, Tom Taghon, Aly A Khan, et al. 2011. “A Cooperative MicroRNA-Tumor Suppressor Gene Network in Acute T-Cell Lymphoblastic Leukemia (T-ALL).” NATURE GENETICS 43 (7): 673–78. https://doi.org/10.1038/ng.858.
- Chicago author-date (all authors)
- Mavrakis, Konstantinos J, Joni Van der Meulen, Andrew L Wolfe, Xiaoping Liu, Evelien Mets, Tom Taghon, Aly A Khan, Manu Setty, Pieter Rondou, Peter Vandenberghe, Eric Delabesse, Yves Benoit, Nicholas B Socci, Christina S Leslie, Pieter Van Vlierberghe, Franki Speleman, and Hans-Guido Wendel. 2011. “A Cooperative MicroRNA-Tumor Suppressor Gene Network in Acute T-Cell Lymphoblastic Leukemia (T-ALL).” NATURE GENETICS 43 (7): 673–678. doi:10.1038/ng.858.
- Vancouver
- 1.Mavrakis KJ, Van der Meulen J, Wolfe AL, Liu X, Mets E, Taghon T, et al. A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL). NATURE GENETICS. 2011;43(7):673–8.
- IEEE
- [1]K. J. Mavrakis et al., “A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL),” NATURE GENETICS, vol. 43, no. 7, pp. 673–678, 2011.
@article{2051743, abstract = {{The importance of individual microRNAs (miRNAs) has been established in specific cancers. However, a comprehensive analysis of the contribution of miRNAs to the pathogenesis of any specific cancer is lacking. Here we show that in T-cell acute lymphoblastic leukemia (T-ALL), a small set of miRNAs is responsible for the cooperative suppression of several tumor suppressor genes. Cross-comparison of miRNA expression profiles in human T-ALL with the results of an unbiased miRNA library screen allowed us to identify five miRNAs (miR-19b, miR-20a, miR-26a, miR-92 and miR-223) that are capable of promoting T-ALL development in a mouse model and which account for the majority of miRNA expression in human T-ALL. Moreover, these miRNAs produce overlapping and cooperative effects on tumor suppressor genes implicated in the pathogenesis of T-ALL, including IKAROS (also known as IKZF1), PTEN, BIM, PHF6, NF1 and FBXW7. Thus, a comprehensive and unbiased analysis of miRNA action in T-ALL reveals a striking pattern of miRNA-tumor suppressor gene.}}, author = {{Mavrakis, Konstantinos J and Van der Meulen, Joni and Wolfe, Andrew L and Liu, Xiaoping and Mets, Evelien and Taghon, Tom and Khan, Aly A and Setty, Manu and Rondou, Pieter and Vandenberghe, Peter and Delabesse, Eric and Benoit, Yves and Socci, Nicholas B and Leslie, Christina S and Van Vlierberghe, Pieter and Speleman, Franki and Wendel, Hans-Guido}}, issn = {{1061-4036}}, journal = {{NATURE GENETICS}}, keywords = {{LEUKEMOGENESIS,RNA,IKAROS,TARGETS,MICE,MUTATIONS,EXPRESSION,NOTCH1,HUMAN CANCERS,C-MYC,T-ALL,leukemia,miRNA,microRNA,cancer}}, language = {{eng}}, number = {{7}}, pages = {{673--678}}, title = {{A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)}}, url = {{http://doi.org/10.1038/ng.858}}, volume = {{43}}, year = {{2011}}, }
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