GPCR oligomerization: contribution to receptor biogenesis
- Author
- Kathleen Van Craenenbroeck (UGent)
- Organization
- Abstract
- G protein-coupled receptor (GPCR) export to the plasma membrane is considered to follow the default secretory pathway. Several observations indicate that traf fi cking from the endoplasmic reticulum to the plasma membrane is strictly regulated and involves interactions with specific proteins, such as resident ER chaperones. These interactions help with GPCR folding, but more importantly, they ensure that only properly folded proteins proceed from the ER to the trans-golgi network. The assembly of several GPCRs into a quaternary structure is started in the ER, before cell surface delivery, and helps in the correct expression of the GPCRs. This review will mainly focus on the role of GPCR oligomerization in receptor biogenesis.
- Keywords
- Dopamine, GABA, Adenosine, Co-immunoprecipitation, BRET, FRET, PLA, Bivalent ligand, G protein-coupled receptors, Oligomerization, Endoplasmic reticulum, Chaperone, Serotonin
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-3260679
- MLA
- Van Craenenbroeck, Kathleen. “GPCR Oligomerization: Contribution to Receptor Biogenesis.” GPCR Signalling Complexes : Synthesis, Assembly, Trafficking and Specificity, edited by Denis J Dupré et al., vol. 63, Springer, 2012, pp. 43–65, doi:10.1007/978-94-007-4765-4_3.
- APA
- Van Craenenbroeck, K. (2012). GPCR oligomerization: contribution to receptor biogenesis. In D. J. Dupré, T. E. Hébert, & R. Jockers (Eds.), GPCR signalling complexes : synthesis, assembly, trafficking and specificity (Vol. 63, pp. 43–65). https://doi.org/10.1007/978-94-007-4765-4_3
- Chicago author-date
- Van Craenenbroeck, Kathleen. 2012. “GPCR Oligomerization: Contribution to Receptor Biogenesis.” In GPCR Signalling Complexes : Synthesis, Assembly, Trafficking and Specificity, edited by Denis J Dupré, Terence E Hébert, and Ralf Jockers, 63:43–65. Dordrecht, The Netherlands: Springer. https://doi.org/10.1007/978-94-007-4765-4_3.
- Chicago author-date (all authors)
- Van Craenenbroeck, Kathleen. 2012. “GPCR Oligomerization: Contribution to Receptor Biogenesis.” In GPCR Signalling Complexes : Synthesis, Assembly, Trafficking and Specificity, ed by. Denis J Dupré, Terence E Hébert, and Ralf Jockers, 63:43–65. Dordrecht, The Netherlands: Springer. doi:10.1007/978-94-007-4765-4_3.
- Vancouver
- 1.Van Craenenbroeck K. GPCR oligomerization: contribution to receptor biogenesis. In: Dupré DJ, Hébert TE, Jockers R, editors. GPCR signalling complexes : synthesis, assembly, trafficking and specificity. Dordrecht, The Netherlands: Springer; 2012. p. 43–65.
- IEEE
- [1]K. Van Craenenbroeck, “GPCR oligomerization: contribution to receptor biogenesis,” in GPCR signalling complexes : synthesis, assembly, trafficking and specificity, vol. 63, D. J. Dupré, T. E. Hébert, and R. Jockers, Eds. Dordrecht, The Netherlands: Springer, 2012, pp. 43–65.
@incollection{3260679, abstract = {{G protein-coupled receptor (GPCR) export to the plasma membrane is considered to follow the default secretory pathway. Several observations indicate that traf fi cking from the endoplasmic reticulum to the plasma membrane is strictly regulated and involves interactions with specific proteins, such as resident ER chaperones. These interactions help with GPCR folding, but more importantly, they ensure that only properly folded proteins proceed from the ER to the trans-golgi network. The assembly of several GPCRs into a quaternary structure is started in the ER, before cell surface delivery, and helps in the correct expression of the GPCRs. This review will mainly focus on the role of GPCR oligomerization in receptor biogenesis.}}, author = {{Van Craenenbroeck, Kathleen}}, booktitle = {{GPCR signalling complexes : synthesis, assembly, trafficking and specificity}}, editor = {{Dupré, Denis J and Hébert, Terence E and Jockers, Ralf}}, isbn = {{9789400747654}}, issn = {{0306-0225}}, keywords = {{Dopamine,GABA,Adenosine,Co-immunoprecipitation,BRET,FRET,PLA,Bivalent ligand,G protein-coupled receptors,Oligomerization,Endoplasmic reticulum,Chaperone,Serotonin}}, language = {{eng}}, pages = {{43--65}}, publisher = {{Springer}}, series = {{Subcellular Biochemistry}}, title = {{GPCR oligomerization: contribution to receptor biogenesis}}, url = {{http://doi.org/10.1007/978-94-007-4765-4_3}}, volume = {{63}}, year = {{2012}}, }
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