Academic Bibliography

 Search 200 years of publications by Ghent University researchers.
Advanced search
1 file | 3.06 MB
Add to list
  1. Search results
  2. Shear stress metrics and their relati...

Shear stress metrics and their relation to atherosclerosis: an in vivo follow-up study in atherosclerotic mice

David De Wilde (UGent) , Bram Trachet (UGent) , Guido RY De Meyer and Patrick Segers (UGent)
(2016) ANNALS OF BIOMEDICAL ENGINEERING. 44(8). p.2327-2338
Author
Organization
Abstract
It is generally accepted that low and oscillatory wall shear stress favors the initiation and development of atherosclerosis. However, a quantitative analysis of the association between shear stress metrics at baseline and lesion prevalence at a later stage is challenging to perform in vivo on a within-subject basis. In this study, we assessed carotid hemodynamics and derived hemodynamic wall parameters from subject-specific fluid-structure interaction simulations in the left and right carotid arteries of 4 ApoE(-/-) mice prior to disease development. We then applied a point-by-point quantitative association (surrogate sample data analysis) between various established and more recent shear related parameters and the extent of macrophage infiltration at a later stage. We conclude that, for the atherosclerotic murine carotid bifurcation, (i) there is an association between hemodynamics and macrophage infiltration; (ii) this correlation is most apparent when assessed at the level of the entire carotid bifurcation; (iii) the strongest spatial correlation between hemodynamics and atherosclerosis development was found for the time averaged wall shear stress (negative correlation) and the relative residence time (positive correlation); (iv) aggregating the data leads to an overestimation of the correlation.
Keywords
Fluid-structure interaction, Wall shear stress, Atherosclerosis, Mouse models, Hemodynamics, CT, CAROTID BIFURCATION, CORONARY-ARTERY, PULSATILE FLOW, PLAQUE

Downloads

  • Download
    (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 3.06 MB

Citation

Please use this url to cite or link to this publication:

MLA
De Wilde, David, et al. “Shear Stress Metrics and Their Relation to Atherosclerosis: An in Vivo Follow-up Study in Atherosclerotic Mice.” ANNALS OF BIOMEDICAL ENGINEERING, vol. 44, no. 8, Springer US, 2016, pp. 2327–38, doi:10.1007/s10439-015-1540-z.
APA
De Wilde, D., Trachet, B., De Meyer, G. R., & Segers, P. (2016). Shear stress metrics and their relation to atherosclerosis: an in vivo follow-up study in atherosclerotic mice. ANNALS OF BIOMEDICAL ENGINEERING, 44(8), 2327–2338. https://doi.org/10.1007/s10439-015-1540-z
Chicago author-date
De Wilde, David, Bram Trachet, Guido RY De Meyer, and Patrick Segers. 2016. “Shear Stress Metrics and Their Relation to Atherosclerosis: An in Vivo Follow-up Study in Atherosclerotic Mice.” ANNALS OF BIOMEDICAL ENGINEERING 44 (8): 2327–38. https://doi.org/10.1007/s10439-015-1540-z.
Chicago author-date (all authors)
De Wilde, David, Bram Trachet, Guido RY De Meyer, and Patrick Segers. 2016. “Shear Stress Metrics and Their Relation to Atherosclerosis: An in Vivo Follow-up Study in Atherosclerotic Mice.” ANNALS OF BIOMEDICAL ENGINEERING 44 (8): 2327–2338. doi:10.1007/s10439-015-1540-z.
Vancouver
1.
De Wilde D, Trachet B, De Meyer GR, Segers P. Shear stress metrics and their relation to atherosclerosis: an in vivo follow-up study in atherosclerotic mice. ANNALS OF BIOMEDICAL ENGINEERING. 2016;44(8):2327–38.
IEEE
[1]
D. De Wilde, B. Trachet, G. R. De Meyer, and P. Segers, “Shear stress metrics and their relation to atherosclerosis: an in vivo follow-up study in atherosclerotic mice,” ANNALS OF BIOMEDICAL ENGINEERING, vol. 44, no. 8, pp. 2327–2338, 2016.
@article{7022532,
  abstract     = {{It is generally accepted that low and oscillatory wall shear stress favors the initiation and development of atherosclerosis. However, a quantitative analysis of the association between shear stress metrics at baseline and lesion prevalence at a later stage is challenging to perform in vivo on a within-subject basis. In this study, we assessed carotid hemodynamics and derived hemodynamic wall parameters from subject-specific fluid-structure interaction simulations in the left and right carotid arteries of 4 ApoE(-/-) mice prior to disease development. We then applied a point-by-point quantitative association (surrogate sample data analysis) between various established and more recent shear related parameters and the extent of macrophage infiltration at a later stage. We conclude that, for the atherosclerotic murine carotid bifurcation, (i) there is an association between hemodynamics and macrophage infiltration; (ii) this correlation is most apparent when assessed at the level of the entire carotid bifurcation; (iii) the strongest spatial correlation between hemodynamics and atherosclerosis development was found for the time averaged wall shear stress (negative correlation) and the relative residence time (positive correlation); (iv) aggregating the data leads to an overestimation of the correlation.}},
  author       = {{De Wilde, David and Trachet, Bram and De Meyer, Guido RY and Segers, Patrick}},
  issn         = {{0090-6964}},
  journal      = {{ANNALS OF BIOMEDICAL ENGINEERING}},
  keywords     = {{Fluid-structure interaction,Wall shear stress,Atherosclerosis,Mouse models,Hemodynamics,CT,CAROTID BIFURCATION,CORONARY-ARTERY,PULSATILE FLOW,PLAQUE}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{2327--2338}},
  publisher    = {{Springer US}},
  title        = {{Shear stress metrics and their relation to atherosclerosis: an in vivo follow-up study in atherosclerotic mice}},
  url          = {{http://doi.org/10.1007/s10439-015-1540-z}},
  volume       = {{44}},
  year         = {{2016}},
}
Altmetric
View in Altmetric
Web of Science
Times cited: