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EEG derived brain activity reflects treatment response from vagus nerve stimulation in patients with epilepsy

Simon Wostyn, Willeke Staljanssens (UGent) , Leen De Taeye (UGent) , Gregor Strobbe (UGent) , Stefanie Gadeyne (UGent) , Dirk Van Roost (UGent) , Robrecht Raedt (UGent) , Kristl Vonck (UGent) and Pieter van Mierlo (UGent)
(2017) INTERNATIONAL JOURNAL OF NEURAL SYSTEMS. 4.
Author
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Abstract
The mechanism of action of vagus nerve stimulation (VNS) is yet to be elucidated. To that end, the effects of VNS on the brain of epileptic patients were studied. Both when VNS was switched “On” and “Off”, the brain activity of responders (R, seizure frequency reduction of over 50%) was compared to the brain activity of nonresponders (NR, seizure frequency reduction of less than 50%). Using EEG recordings, a significant increase in P300 amplitude for R and a significant decrease in P300 amplitude for NR were found. We found biomarkers for checking the efficacy of VNS with accuracy up to 94%. The results show that P300 features recorded in nonmidline electrodes are better P300 biomarkers for VNS efficacy than P300 features recorded in midline electrodes. Using source localization and connectivity analyses, the activity of the limbic system, insula and orbitofrontal cortex was found to be dependent on VNS switched “On” versus “Off” or patient group (R versus NR). The results suggest an important role for these areas in the mechanism of action of VNS, although a larger patient study should be done to confirm the findings.
Keywords
electrical source imaging, betweenness centrality, P300, Epilepsy, VNS, functional directed connectivity, MAJOR DEPRESSIVE DISORDER, TEMPORAL-LOBE EPILEPSY, LOCUS-COERULEUS, CONNECTIVITY, EFFICACY, SEIZURES, MECHANISM, BIOMARKER, NETWORKS, SYSTEM

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MLA
Wostyn, Simon, et al. “EEG Derived Brain Activity Reflects Treatment Response from Vagus Nerve Stimulation in Patients with Epilepsy.” INTERNATIONAL JOURNAL OF NEURAL SYSTEMS, vol. 4, 2017, doi:10.1142/S0129065716500489.
APA
Wostyn, S., Staljanssens, W., De Taeye, L., Strobbe, G., Gadeyne, S., Van Roost, D., … van Mierlo, P. (2017). EEG derived brain activity reflects treatment response from vagus nerve stimulation in patients with epilepsy. INTERNATIONAL JOURNAL OF NEURAL SYSTEMS, 4. https://doi.org/10.1142/S0129065716500489
Chicago author-date
Wostyn, Simon, Willeke Staljanssens, Leen De Taeye, Gregor Strobbe, Stefanie Gadeyne, Dirk Van Roost, Robrecht Raedt, Kristl Vonck, and Pieter van Mierlo. 2017. “EEG Derived Brain Activity Reflects Treatment Response from Vagus Nerve Stimulation in Patients with Epilepsy.” INTERNATIONAL JOURNAL OF NEURAL SYSTEMS 4. https://doi.org/10.1142/S0129065716500489.
Chicago author-date (all authors)
Wostyn, Simon, Willeke Staljanssens, Leen De Taeye, Gregor Strobbe, Stefanie Gadeyne, Dirk Van Roost, Robrecht Raedt, Kristl Vonck, and Pieter van Mierlo. 2017. “EEG Derived Brain Activity Reflects Treatment Response from Vagus Nerve Stimulation in Patients with Epilepsy.” INTERNATIONAL JOURNAL OF NEURAL SYSTEMS 4. doi:10.1142/S0129065716500489.
Vancouver
1.
Wostyn S, Staljanssens W, De Taeye L, Strobbe G, Gadeyne S, Van Roost D, et al. EEG derived brain activity reflects treatment response from vagus nerve stimulation in patients with epilepsy. INTERNATIONAL JOURNAL OF NEURAL SYSTEMS. 2017;4.
IEEE
[1]
S. Wostyn et al., “EEG derived brain activity reflects treatment response from vagus nerve stimulation in patients with epilepsy,” INTERNATIONAL JOURNAL OF NEURAL SYSTEMS, vol. 4, 2017.
@article{8121459,
  abstract     = {{The mechanism of action of vagus nerve stimulation (VNS) is yet to be elucidated. To that end, the effects of VNS on the brain of epileptic patients were studied. Both when VNS was switched “On” and “Off”, the brain activity of responders (R, seizure frequency reduction of over 50%) was compared to the brain activity of nonresponders (NR, seizure frequency reduction of less than 50%). Using EEG recordings, a significant increase in P300 amplitude for R and a significant decrease in P300 amplitude for NR were found. We found biomarkers for checking the efficacy of VNS with accuracy up to 94%. The results show that P300 features recorded in nonmidline electrodes are better P300 biomarkers for VNS efficacy than P300 features recorded in midline electrodes. Using source localization and connectivity analyses, the activity of the limbic system, insula and orbitofrontal cortex was found to be dependent on VNS switched “On” versus “Off” or patient group (R versus NR). The results suggest an important role for these areas in the mechanism of action of VNS, although a larger patient study should be done to confirm the findings.}},
  articleno    = {{1650048}},
  author       = {{Wostyn, Simon and Staljanssens, Willeke and De Taeye, Leen and Strobbe, Gregor and Gadeyne, Stefanie and Van Roost, Dirk and Raedt, Robrecht and Vonck, Kristl and van Mierlo, Pieter}},
  issn         = {{0129-0657}},
  journal      = {{INTERNATIONAL JOURNAL OF NEURAL SYSTEMS}},
  keywords     = {{electrical source imaging,betweenness centrality,P300,Epilepsy,VNS,functional directed connectivity,MAJOR DEPRESSIVE DISORDER,TEMPORAL-LOBE EPILEPSY,LOCUS-COERULEUS,CONNECTIVITY,EFFICACY,SEIZURES,MECHANISM,BIOMARKER,NETWORKS,SYSTEM}},
  language     = {{eng}},
  pages        = {{12}},
  title        = {{EEG derived brain activity reflects treatment response from vagus nerve stimulation in patients with epilepsy}},
  url          = {{http://doi.org/10.1142/S0129065716500489}},
  volume       = {{4}},
  year         = {{2017}},
}
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