Plant lectins targeting O-glycans at the cell surface as tools for cancer diagnosis, orognosis and therapy
- Author
- Guillaume Poiroux, Annick Barre, Els Van Damme (UGent) , Hervé Benoist and Pierre Rougé
- Organization
- Abstract
- Aberrant O-glycans expressed at the surface of cancer cells consist of membrane-tethered glycoproteins (T and Tn antigens) and glycolipids (Lewis a, Lewis x and Forssman antigens). All of these O-glycans have been identified as glyco-markers of interest for the diagnosis and the prognosis of cancer diseases. These epitopes are specifically detected using T/Tn-specific lectins isolated from various plants such as jacalin from Artocarpus integrifola, and fungi such as the Agaricus bisporus lectin. These lectins accommodate T/Tn antigens at the monosaccharide-binding site; residues located in the surrounding extended binding-site of the lectins often participate in the binding of more extended epitopes. Depending on the shape and size of the extended carbohydrate-binding site, their fine sugar-binding specificity towards complex O-glycans readily differs from one lectin to another, resulting in a great diversity in their sugar-recognition capacity. T/Tn-specific lectins have been extensively used for the histochemical detection of cancer cells in biopsies and for the follow up of the cancer progression and evolution. T/Tn-specific lectins also induce a caspase-dependent apoptosis in cancer cells, often associated with a more or less severe inhibition of proliferation. Moreover, they provide another potential source of molecules adapted to the building of photosensitizer-conjugates allowing a specific targeting to cancer cells, for the photodynamic treatment of tumors.
- Keywords
- HUMAN BREAST-CANCER, RIBOSOME-INACTIVATING PROTEIN, THOMSEN-FRIEDENREICH, ANTIGEN, WHEAT-GERM-AGGLUTININ, CARBOHYDRATE-BINDING SPECIFICITIES, AMARANTHUS-LEUCOCARPUS LECTIN, MUSHROOM AGARICUS-BISPORUS, BAUHINIA-FORFICATA LECTIN, SCLEROTIUM-ROLFSII LECTIN, MOLUCCELLA-LAEVIS, LECTIN, lectin, O-glycosylation, Tn antigen, T antigen, Morniga G, peanut, lectin, cancer, diagnosis, prognosis, photodynamic therapy
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8546386
- MLA
- Poiroux, Guillaume, et al. “Plant Lectins Targeting O-Glycans at the Cell Surface as Tools for Cancer Diagnosis, Orognosis and Therapy.” INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 18, no. 6, 2017, doi:10.3390/ijms18061232.
- APA
- Poiroux, G., Barre, A., Van Damme, E., Benoist, H., & Rougé, P. (2017). Plant lectins targeting O-glycans at the cell surface as tools for cancer diagnosis, orognosis and therapy. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(6). https://doi.org/10.3390/ijms18061232
- Chicago author-date
- Poiroux, Guillaume, Annick Barre, Els Van Damme, Hervé Benoist, and Pierre Rougé. 2017. “Plant Lectins Targeting O-Glycans at the Cell Surface as Tools for Cancer Diagnosis, Orognosis and Therapy.” INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18 (6). https://doi.org/10.3390/ijms18061232.
- Chicago author-date (all authors)
- Poiroux, Guillaume, Annick Barre, Els Van Damme, Hervé Benoist, and Pierre Rougé. 2017. “Plant Lectins Targeting O-Glycans at the Cell Surface as Tools for Cancer Diagnosis, Orognosis and Therapy.” INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18 (6). doi:10.3390/ijms18061232.
- Vancouver
- 1.Poiroux G, Barre A, Van Damme E, Benoist H, Rougé P. Plant lectins targeting O-glycans at the cell surface as tools for cancer diagnosis, orognosis and therapy. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2017;18(6).
- IEEE
- [1]G. Poiroux, A. Barre, E. Van Damme, H. Benoist, and P. Rougé, “Plant lectins targeting O-glycans at the cell surface as tools for cancer diagnosis, orognosis and therapy,” INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 18, no. 6, 2017.
@article{8546386, abstract = {{Aberrant O-glycans expressed at the surface of cancer cells consist of membrane-tethered glycoproteins (T and Tn antigens) and glycolipids (Lewis a, Lewis x and Forssman antigens). All of these O-glycans have been identified as glyco-markers of interest for the diagnosis and the prognosis of cancer diseases. These epitopes are specifically detected using T/Tn-specific lectins isolated from various plants such as jacalin from Artocarpus integrifola, and fungi such as the Agaricus bisporus lectin. These lectins accommodate T/Tn antigens at the monosaccharide-binding site; residues located in the surrounding extended binding-site of the lectins often participate in the binding of more extended epitopes. Depending on the shape and size of the extended carbohydrate-binding site, their fine sugar-binding specificity towards complex O-glycans readily differs from one lectin to another, resulting in a great diversity in their sugar-recognition capacity. T/Tn-specific lectins have been extensively used for the histochemical detection of cancer cells in biopsies and for the follow up of the cancer progression and evolution. T/Tn-specific lectins also induce a caspase-dependent apoptosis in cancer cells, often associated with a more or less severe inhibition of proliferation. Moreover, they provide another potential source of molecules adapted to the building of photosensitizer-conjugates allowing a specific targeting to cancer cells, for the photodynamic treatment of tumors.}}, articleno = {{1232}}, author = {{Poiroux, Guillaume and Barre, Annick and Van Damme, Els and Benoist, Hervé and Rougé, Pierre}}, issn = {{1422-0067}}, journal = {{INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}}, keywords = {{HUMAN BREAST-CANCER,RIBOSOME-INACTIVATING PROTEIN,THOMSEN-FRIEDENREICH,ANTIGEN,WHEAT-GERM-AGGLUTININ,CARBOHYDRATE-BINDING SPECIFICITIES,AMARANTHUS-LEUCOCARPUS LECTIN,MUSHROOM AGARICUS-BISPORUS,BAUHINIA-FORFICATA LECTIN,SCLEROTIUM-ROLFSII LECTIN,MOLUCCELLA-LAEVIS,LECTIN,lectin,O-glycosylation,Tn antigen,T antigen,Morniga G,peanut,lectin,cancer,diagnosis,prognosis,photodynamic therapy}}, language = {{eng}}, number = {{6}}, pages = {{30}}, title = {{Plant lectins targeting O-glycans at the cell surface as tools for cancer diagnosis, orognosis and therapy}}, url = {{http://doi.org/10.3390/ijms18061232}}, volume = {{18}}, year = {{2017}}, }
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