@article{8573245,
  abstract     = {{Cyclic lipodepsipeptides produced by Pseudomonas spp. (Ps-CLPs) are biosurfactants that constitute a diverse class of versatile bioactive natural compounds with promising application potential. While chemically diverse, they obey a common structural blue-print, allowing the definition of 14 distinct groups with multiple structurally homologous members. In addition to antibacterial and antifungal properties the reported activity profile of Ps-CLPs includes their effect on bacterial motility, biofilm formation, induced defense responses in plants, their insecticidal activity and anti-proliferation effects on human cancer cell-lines. To further validate their status of potential bioactive substances, we assessed the results of 775 biological tests on 51 Ps-CLPs available from literature. From this, a fragmented view emerges. Taken as a group, Ps-CLPs present a broad activity profile. However, reports on individual Ps-CLPs are often much more limited in the scope of organisms that are challenged or activities that are explored. As a result, our analysis shows that the available data is currently too sparse to allow biological function to be correlated to a particular group of Ps-CLPs. Consequently, certain generalizations that appear in literature with respect to the biological activities of Ps-CLPs should be nuanced. This notwithstanding, the data for the two most extensively studied Ps-CLPs does indicate they can display activities against various biological targets. As the discovery of novel Ps-CLPs accelerates, current challenges to complete and maintain a useful overview of biological activity are discussed.}},
  articleno    = {{1867}},
  author       = {{Geudens, Niels and Martins, José}},
  issn         = {{1664-302X}},
  journal      = {{FRONTIERS IN MICROBIOLOGY}},
  keywords     = {{amphiphile,lipopeptides,Pseudomonas,biological activities,metabolite,LINE-INDUCING PRINCIPLE,SYRINGAE PV SYRINGAE,SP STRAIN DSS73,INDUCED SYSTEMIC RESISTANCE,CHANNEL-FORMING ACTIVITIES,SYRINGOMYCIN-E CHANNELS,SUGAR-BEET RHIZOSPHERE,PLANT-GROWTH PROMOTION,SIDE-CHAIN ANALOGS,LIPOPEPTIDE PRODUCTION}},
  language     = {{eng}},
  pages        = {{18}},
  title        = {{Cyclic lipodepsipeptides from Pseudomonas spp. : biological Swiss-army knives}},
  url          = {{http://doi.org/10.3389/fmicb.2018.01867}},
  volume       = {{9}},
  year         = {{2018}},
}

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