Metabolic editing : small measures, great impact
- Author
- Gwen Swinnen, Alain Goossens (UGent) and Maite Colinas Martinez (UGent)
- Organization
- Abstract
- Metabolic pathways are tightly regulated at the transcriptional and post-translational level, often relying on protein-protein interactions or post-translational protein modifications. Whereas these principles have been established already for a long time, the number of experimentally established cases is expected to rise exponentially in the near future as a result of recent advances in protein-based detection methods. Interactions and modifications are often dependent on only short amino-acid sequences that represent excellent targets for new gene editing technologies by which specific base pairs can be exchanged. Here, we introduce the concept of metabolic editing, which is based on identifying specific amino-acid sequences that are subsequently targeted for gene editing. The proposed workflow will serve for both applied metabolic engineering purposes and proof-of-concept studies in fundamental research.
- Keywords
- POSTTRANSLATIONAL MODIFICATIONS, TRANSCRIPTION FACTORS, PROTEIN-PROTEIN, GLUCOSINOLATE BIOSYNTHESIS, BIOTIN LIGASE, AMINO-ACID, MYC2, REPRESSION, PREDICTION, DIVERSITY
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8607603
- MLA
- Swinnen, Gwen, et al. “Metabolic Editing : Small Measures, Great Impact.” CURRENT OPINION IN BIOTECHNOLOGY, edited by Marjan De Mey and Eveline Peeters, vol. 59, 2019, pp. 16–23, doi:10.1016/j.copbio.2019.02.002.
- APA
- Swinnen, G., Goossens, A., & Colinas Martinez, M. (2019). Metabolic editing : small measures, great impact. CURRENT OPINION IN BIOTECHNOLOGY, 59, 16–23. https://doi.org/10.1016/j.copbio.2019.02.002
- Chicago author-date
- Swinnen, Gwen, Alain Goossens, and Maite Colinas Martinez. 2019. “Metabolic Editing : Small Measures, Great Impact.” Edited by Marjan De Mey and Eveline Peeters. CURRENT OPINION IN BIOTECHNOLOGY 59: 16–23. https://doi.org/10.1016/j.copbio.2019.02.002.
- Chicago author-date (all authors)
- Swinnen, Gwen, Alain Goossens, and Maite Colinas Martinez. 2019. “Metabolic Editing : Small Measures, Great Impact.” Ed by. Marjan De Mey and Eveline Peeters. CURRENT OPINION IN BIOTECHNOLOGY 59: 16–23. doi:10.1016/j.copbio.2019.02.002.
- Vancouver
- 1.Swinnen G, Goossens A, Colinas Martinez M. Metabolic editing : small measures, great impact. De Mey M, Peeters E, editors. CURRENT OPINION IN BIOTECHNOLOGY. 2019;59:16–23.
- IEEE
- [1]G. Swinnen, A. Goossens, and M. Colinas Martinez, “Metabolic editing : small measures, great impact,” CURRENT OPINION IN BIOTECHNOLOGY, vol. 59, pp. 16–23, 2019.
@article{8607603,
abstract = {{Metabolic pathways are tightly regulated at the transcriptional and post-translational level, often relying on protein-protein interactions or post-translational protein modifications. Whereas these principles have been established already for a long time, the number of experimentally established cases is expected to rise exponentially in the near future as a result of recent advances in protein-based detection methods. Interactions and modifications are often dependent on only short amino-acid sequences that represent excellent targets for new gene editing technologies by which specific base pairs can be exchanged. Here, we introduce the concept of metabolic editing, which is based on identifying specific amino-acid sequences that are subsequently targeted for gene editing. The proposed workflow will serve for both applied metabolic engineering purposes and proof-of-concept studies in fundamental research.}},
author = {{Swinnen, Gwen and Goossens, Alain and Colinas Martinez, Maite}},
editor = {{De Mey, Marjan and Peeters, Eveline}},
issn = {{0958-1669}},
journal = {{CURRENT OPINION IN BIOTECHNOLOGY}},
keywords = {{POSTTRANSLATIONAL MODIFICATIONS,TRANSCRIPTION FACTORS,PROTEIN-PROTEIN,GLUCOSINOLATE BIOSYNTHESIS,BIOTIN LIGASE,AMINO-ACID,MYC2,REPRESSION,PREDICTION,DIVERSITY}},
language = {{eng}},
pages = {{16--23}},
title = {{Metabolic editing : small measures, great impact}},
url = {{http://doi.org/10.1016/j.copbio.2019.02.002}},
volume = {{59}},
year = {{2019}},
}
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