Pd(II) and Pt(II) metallacycles with unsymmetrical ylide : antiproliferative effects and application in electrocatalytic oxidation of methanol
- Author
- Mojdeh Sadat Hashemi, Seyyed Javad Sabounchei, Roya Karamian, Seyed Hamed Moazzami Farida, Nosrat Rahmani, Mahmoud Roushani and Kristof Van Hecke (UGent)
- Organization
- Abstract
- New Pd(II) and Pt(II) complexes are described in which the multidentate phosphorus ylides [Ph2P(CH2)(n)PPh2=C(H)C(O)C6H4-p-OCH3] (n=1, (Y1); n=2, (Y2)) act as P,C chelating ligands. The chelating ability of these ligands resulted in the formation of [MBr2{K-2(P,C)-Y1}] (M=Pd (1), Pt (2)); [MBr2{K-2(P,C)-Y2}] (M=Pd (3), Pt (4) complexes, which were investigated using physicochemical techniques. X-ray diffraction studies of a single crystal of complex 2 confirmed the structure of the five-membered ring. Owing to the redox activity of phosphorus-ylide complexes, their electrocatalytic activity for the oxidation of methanol has been studied. All compounds were found to possess the anti-proliferative potency against MCF-7 (breast carcinoma), A549 (non-small lung carcinoma) and AGS (gastric carcinoma) cell lines with average IC50 values in the range of 14.53 to 287.92 mu M. In general, the compounds Y1, Y2, 2, and 3 displayed high anticancer activities compared to 1 and 4. The antioxidant activity of the compounds, which was estimated by 1, 1-diphenyl-2-picryl-hydrazyl (DPPH) free radical scavenging, was moderate to strong with IC50 values in the range 0.18 to 0.59 mg mL(-1).
- Keywords
- PHOSPHORUS YLIDES, PALLADIUM(II) COMPLEXES, PLATINUM(II) COMPLEXES, CRYSTAL-STRUCTURES, DAPTA LIGANDS, CYTOTOXICITY, DERIVATIVES, NANOPARTICLES, ANTICANCER, CATALYSTS, Multifunctional phosphorus ylides, X-ray diffraction studies, Oxidation of methanol, Cytotoxicity, Antioxidant activity
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8645672
- MLA
- Hashemi, Mojdeh Sadat, et al. “Pd(II) and Pt(II) Metallacycles with Unsymmetrical Ylide : Antiproliferative Effects and Application in Electrocatalytic Oxidation of Methanol.” CHEMISTRYSELECT, vol. 4, no. 38, 2019, pp. 11398–405, doi:10.1002/slct.201902065.
- APA
- Hashemi, M. S., Sabounchei, S. J., Karamian, R., Farida, S. H. M., Rahmani, N., Roushani, M., & Van Hecke, K. (2019). Pd(II) and Pt(II) metallacycles with unsymmetrical ylide : antiproliferative effects and application in electrocatalytic oxidation of methanol. CHEMISTRYSELECT, 4(38), 11398–11405. https://doi.org/10.1002/slct.201902065
- Chicago author-date
- Hashemi, Mojdeh Sadat, Seyyed Javad Sabounchei, Roya Karamian, Seyed Hamed Moazzami Farida, Nosrat Rahmani, Mahmoud Roushani, and Kristof Van Hecke. 2019. “Pd(II) and Pt(II) Metallacycles with Unsymmetrical Ylide : Antiproliferative Effects and Application in Electrocatalytic Oxidation of Methanol.” CHEMISTRYSELECT 4 (38): 11398–405. https://doi.org/10.1002/slct.201902065.
- Chicago author-date (all authors)
- Hashemi, Mojdeh Sadat, Seyyed Javad Sabounchei, Roya Karamian, Seyed Hamed Moazzami Farida, Nosrat Rahmani, Mahmoud Roushani, and Kristof Van Hecke. 2019. “Pd(II) and Pt(II) Metallacycles with Unsymmetrical Ylide : Antiproliferative Effects and Application in Electrocatalytic Oxidation of Methanol.” CHEMISTRYSELECT 4 (38): 11398–11405. doi:10.1002/slct.201902065.
- Vancouver
- 1.Hashemi MS, Sabounchei SJ, Karamian R, Farida SHM, Rahmani N, Roushani M, et al. Pd(II) and Pt(II) metallacycles with unsymmetrical ylide : antiproliferative effects and application in electrocatalytic oxidation of methanol. CHEMISTRYSELECT. 2019;4(38):11398–405.
- IEEE
- [1]M. S. Hashemi et al., “Pd(II) and Pt(II) metallacycles with unsymmetrical ylide : antiproliferative effects and application in electrocatalytic oxidation of methanol,” CHEMISTRYSELECT, vol. 4, no. 38, pp. 11398–11405, 2019.
@article{8645672,
abstract = {{New Pd(II) and Pt(II) complexes are described in which the multidentate phosphorus ylides [Ph2P(CH2)(n)PPh2=C(H)C(O)C6H4-p-OCH3] (n=1, (Y1); n=2, (Y2)) act as P,C chelating ligands. The chelating ability of these ligands resulted in the formation of [MBr2{K-2(P,C)-Y1}] (M=Pd (1), Pt (2)); [MBr2{K-2(P,C)-Y2}] (M=Pd (3), Pt (4) complexes, which were investigated using physicochemical techniques. X-ray diffraction studies of a single crystal of complex 2 confirmed the structure of the five-membered ring. Owing to the redox activity of phosphorus-ylide complexes, their electrocatalytic activity for the oxidation of methanol has been studied. All compounds were found to possess the anti-proliferative potency against MCF-7 (breast carcinoma), A549 (non-small lung carcinoma) and AGS (gastric carcinoma) cell lines with average IC50 values in the range of 14.53 to 287.92 mu M. In general, the compounds Y1, Y2, 2, and 3 displayed high anticancer activities compared to 1 and 4. The antioxidant activity of the compounds, which was estimated by 1, 1-diphenyl-2-picryl-hydrazyl (DPPH) free radical scavenging, was moderate to strong with IC50 values in the range 0.18 to 0.59 mg mL(-1).}},
author = {{Hashemi, Mojdeh Sadat and Sabounchei, Seyyed Javad and Karamian, Roya and Farida, Seyed Hamed Moazzami and Rahmani, Nosrat and Roushani, Mahmoud and Van Hecke, Kristof}},
issn = {{2365-6549}},
journal = {{CHEMISTRYSELECT}},
keywords = {{PHOSPHORUS YLIDES,PALLADIUM(II) COMPLEXES,PLATINUM(II) COMPLEXES,CRYSTAL-STRUCTURES,DAPTA LIGANDS,CYTOTOXICITY,DERIVATIVES,NANOPARTICLES,ANTICANCER,CATALYSTS,Multifunctional phosphorus ylides,X-ray diffraction studies,Oxidation of methanol,Cytotoxicity,Antioxidant activity}},
language = {{eng}},
number = {{38}},
pages = {{11398--11405}},
title = {{Pd(II) and Pt(II) metallacycles with unsymmetrical ylide : antiproliferative effects and application in electrocatalytic oxidation of methanol}},
url = {{http://doi.org/10.1002/slct.201902065}},
volume = {{4}},
year = {{2019}},
}
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