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Microbial fatty acid transport proteins and their biotechnological potential

(2021) BIOTECHNOLOGY AND BIOENGINEERING. 118(6). p.2184-2201
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Abstract
Fatty acid metabolism has been widely studied in various organisms. However, fatty acid transport has received less attention, even though it plays vital physiological roles, such as export of toxic free fatty acids or uptake of exogenous fatty acids. Hence, there are important knowledge gaps in how fatty acids cross biological membranes, and many mechanisms and proteins involved in these processes still need to be determined. The lack of information is more predominant in microorganisms, even though the identification of fatty acids transporters in these cells could lead to establishing new drug targets or improvements in microbial cell factories. This review provides a thorough analysis of the current information on fatty acid transporters in microorganisms, including bacteria, yeasts and microalgae species. Most available information relates to the model organisms Escherichia coli and Saccharomyces cerevisiae, but transport systems of other species are also discussed. Intracellular trafficking of fatty acids and their transport through organelle membranes in eukaryotic organisms is described as well. Finally, applied studies and engineering efforts using fatty acids transporters are presented to show the applied potential of these transporters and to stress the need for further identification of new transporters and their engineering.
Keywords
bacteria, fatty acid, membrane transport engineering, microalgae, yeast

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Citation

Please use this url to cite or link to this publication:

MLA
Salvador López, José Manuel, and Inge Van Bogaert. “Microbial Fatty Acid Transport Proteins and Their Biotechnological Potential.” BIOTECHNOLOGY AND BIOENGINEERING, vol. 118, no. 6, 2021, pp. 2184–201, doi:10.1002/bit.27735.
APA
Salvador López, J. M., & Van Bogaert, I. (2021). Microbial fatty acid transport proteins and their biotechnological potential. BIOTECHNOLOGY AND BIOENGINEERING, 118(6), 2184–2201. https://doi.org/10.1002/bit.27735
Chicago author-date
Salvador López, José Manuel, and Inge Van Bogaert. 2021. “Microbial Fatty Acid Transport Proteins and Their Biotechnological Potential.” BIOTECHNOLOGY AND BIOENGINEERING 118 (6): 2184–2201. https://doi.org/10.1002/bit.27735.
Chicago author-date (all authors)
Salvador López, José Manuel, and Inge Van Bogaert. 2021. “Microbial Fatty Acid Transport Proteins and Their Biotechnological Potential.” BIOTECHNOLOGY AND BIOENGINEERING 118 (6): 2184–2201. doi:10.1002/bit.27735.
Vancouver
1.
Salvador López JM, Van Bogaert I. Microbial fatty acid transport proteins and their biotechnological potential. BIOTECHNOLOGY AND BIOENGINEERING. 2021;118(6):2184–201.
IEEE
[1]
J. M. Salvador López and I. Van Bogaert, “Microbial fatty acid transport proteins and their biotechnological potential,” BIOTECHNOLOGY AND BIOENGINEERING, vol. 118, no. 6, pp. 2184–2201, 2021.
@article{8695586,
  abstract     = {{Fatty acid metabolism has been widely studied in various organisms. However, fatty acid transport has received less attention, even though it plays vital physiological roles, such as export of toxic free fatty acids or uptake of exogenous fatty acids. Hence, there are important knowledge gaps in how fatty acids cross biological membranes, and many mechanisms and proteins involved in these processes still need to be determined. The lack of information is more predominant in microorganisms, even though the identification of fatty acids transporters in these cells could lead to establishing new drug targets or improvements in microbial cell factories. This review provides a thorough analysis of the current information on fatty acid transporters in microorganisms, including bacteria, yeasts and microalgae species. Most available information relates to the model organisms Escherichia coli and Saccharomyces cerevisiae, but transport systems of other species are also discussed. Intracellular trafficking of fatty acids and their transport through organelle membranes in eukaryotic organisms is described as well. Finally, applied studies and engineering efforts using fatty acids transporters are presented to show the applied potential of these transporters and to stress the need for further identification of new transporters and their engineering.}},
  author       = {{Salvador López, José Manuel and Van Bogaert, Inge}},
  issn         = {{0006-3592}},
  journal      = {{BIOTECHNOLOGY AND BIOENGINEERING}},
  keywords     = {{bacteria,fatty acid,membrane transport engineering,microalgae,yeast}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{2184--2201}},
  title        = {{Microbial fatty acid transport proteins and their biotechnological potential}},
  url          = {{http://doi.org/10.1002/bit.27735}},
  volume       = {{118}},
  year         = {{2021}},
}

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