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Man-specific, GalNAc/T/Tn-specific and Neu5Ac-specific seaweed lectins as glycan probes for the SARS-CoV-2 (COVID-19) coronavirus

(2020) MARINE DRUGS. 18(11).
Author
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Abstract
Seaweed lectins, especially high-mannose-specific lectins from red algae, have been identified as potential antiviral agents that are capable of blocking the replication of various enveloped viruses like influenza virus, herpes virus, and HIV-1 in vitro. Their antiviral activity depends on the recognition of glycoprotein receptors on the surface of sensitive host cells—in particular, hemagglutinin for influenza virus or gp120 for HIV-1, which in turn triggers fusion events, allowing the entry of the viral genome into the cells and its subsequent replication. The diversity of glycans present on the S-glycoproteins forming the spikes covering the SARS-CoV-2 envelope, essentially complex type N-glycans and high-mannose type N-glycans, suggests that high-mannose-specific seaweed lectins are particularly well adapted as glycan probes for coronaviruses. This review presents a detailed study of the carbohydrate-binding specificity of high-mannose-specific seaweed lectins, demonstrating their potential to be used as specific glycan probes for coronaviruses, as well as the biomedical interest for both the detection and immobilization of SARS-CoV-2 to avoid shedding of the virus into the environment. The use of these seaweed lectins as replication blockers for SARS-CoV-2 is also discussed.
Keywords
Drug Discovery, seaweed lectins, red algae, mannose-specific lectins, N-acetylgalactosamine-specific lectins, T, Tn-specific lectins, griffithsin, SARS-CoV-2, COVID-19, N-glycosylation, O-glycosylation, high-mannose glycans, glycan probes, ALGA EUCHEUMA-SERRA, MARINE RED ALGA, MANNOSE-BINDING LECTIN, ANTI-HIV ACTIVITY, CYANOVIRIN-N, CARBOHYDRATE-BINDING, CRYSTAL-STRUCTURE, STRUCTURAL BASIS, ENTRY INHIBITOR, BOODLEA-COACTA

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Citation

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MLA
Barre, Annick, et al. “Man-Specific, GalNAc/T/Tn-Specific and Neu5Ac-Specific Seaweed Lectins as Glycan Probes for the SARS-CoV-2 (COVID-19) Coronavirus.” MARINE DRUGS, vol. 18, no. 11, 2020, doi:10.3390/md18110543.
APA
Barre, A., Van Damme, E., Simplicien, M., Benoist, H., & Rougé, P. (2020). Man-specific, GalNAc/T/Tn-specific and Neu5Ac-specific seaweed lectins as glycan probes for the SARS-CoV-2 (COVID-19) coronavirus. MARINE DRUGS, 18(11). https://doi.org/10.3390/md18110543
Chicago author-date
Barre, Annick, Els Van Damme, Mathias Simplicien, Hervé Benoist, and Pierre Rougé. 2020. “Man-Specific, GalNAc/T/Tn-Specific and Neu5Ac-Specific Seaweed Lectins as Glycan Probes for the SARS-CoV-2 (COVID-19) Coronavirus.” MARINE DRUGS 18 (11). https://doi.org/10.3390/md18110543.
Chicago author-date (all authors)
Barre, Annick, Els Van Damme, Mathias Simplicien, Hervé Benoist, and Pierre Rougé. 2020. “Man-Specific, GalNAc/T/Tn-Specific and Neu5Ac-Specific Seaweed Lectins as Glycan Probes for the SARS-CoV-2 (COVID-19) Coronavirus.” MARINE DRUGS 18 (11). doi:10.3390/md18110543.
Vancouver
1.
Barre A, Van Damme E, Simplicien M, Benoist H, Rougé P. Man-specific, GalNAc/T/Tn-specific and Neu5Ac-specific seaweed lectins as glycan probes for the SARS-CoV-2 (COVID-19) coronavirus. MARINE DRUGS. 2020;18(11).
IEEE
[1]
A. Barre, E. Van Damme, M. Simplicien, H. Benoist, and P. Rougé, “Man-specific, GalNAc/T/Tn-specific and Neu5Ac-specific seaweed lectins as glycan probes for the SARS-CoV-2 (COVID-19) coronavirus,” MARINE DRUGS, vol. 18, no. 11, 2020.
@article{8696029,
  abstract     = {{Seaweed lectins, especially high-mannose-specific lectins from red algae, have been identified as potential antiviral agents that are capable of blocking the replication of various enveloped viruses like influenza virus, herpes virus, and HIV-1 in vitro. Their antiviral activity depends on the recognition of glycoprotein receptors on the surface of sensitive host cells—in particular, hemagglutinin for influenza virus or gp120 for HIV-1, which in turn triggers fusion events, allowing the entry of the viral genome into the cells and its subsequent replication. The diversity of glycans present on the S-glycoproteins forming the spikes covering the SARS-CoV-2 envelope, essentially complex type N-glycans and high-mannose type N-glycans, suggests that high-mannose-specific seaweed lectins are particularly well adapted as glycan probes for coronaviruses. This review presents a detailed study of the carbohydrate-binding specificity of high-mannose-specific seaweed lectins, demonstrating their potential to be used as specific glycan probes for coronaviruses, as well as the biomedical interest for both the detection and immobilization of SARS-CoV-2 to avoid shedding of the virus into the environment. The use of these seaweed lectins as replication blockers for SARS-CoV-2 is also discussed.}},
  articleno    = {{543}},
  author       = {{Barre, Annick and Van Damme, Els and Simplicien, Mathias and Benoist, Hervé and Rougé, Pierre}},
  issn         = {{1660-3397}},
  journal      = {{MARINE DRUGS}},
  keywords     = {{Drug Discovery,seaweed lectins,red algae,mannose-specific lectins,N-acetylgalactosamine-specific lectins,T,Tn-specific lectins,griffithsin,SARS-CoV-2,COVID-19,N-glycosylation,O-glycosylation,high-mannose glycans,glycan probes,ALGA EUCHEUMA-SERRA,MARINE RED ALGA,MANNOSE-BINDING LECTIN,ANTI-HIV ACTIVITY,CYANOVIRIN-N,CARBOHYDRATE-BINDING,CRYSTAL-STRUCTURE,STRUCTURAL BASIS,ENTRY INHIBITOR,BOODLEA-COACTA}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{25}},
  title        = {{Man-specific, GalNAc/T/Tn-specific and Neu5Ac-specific seaweed lectins as glycan probes for the SARS-CoV-2 (COVID-19) coronavirus}},
  url          = {{http://doi.org/10.3390/md18110543}},
  volume       = {{18}},
  year         = {{2020}},
}

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