Bone phenotyping approaches in human, mice and zebrafish : expert overview of the EU cost action gemstone ('GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork')

Foessl, Ines; Bassett, J. H. Duncan; Bjørnerem, Åshild; Busse, Björn; Calado, Ângelo; Chavassieux, Pascale; Christou, Maria; Douni, Eleni; Fiedler, Imke A. K.; Fonseca, João Eurico; Hassler, Eva; Högler, Wolfgang; Kague, Erika; Karasik, David; Khashayar, Patricia; Langdahl, Bente L.; Leitch, Victoria D.; Lopes, Philippe; Markozannes, Georgios; McGuigan, Fiona E. A.; Medina-Gomez, Carolina; Ntzani, Evangelia; Oei, Ling; Ohlsson, Claes; Szulc, Pawel; Tobias, Jonathan H.; Trajanoska, Katerina; Tuzun, Şansın; Valjevac, Amina; van Rietbergen, Bert; Williams, Graham R.; Zekic, Tatjana; Rivadeneira, Fernando; Obermayer-Pietsch, Barbara

Bone phenotyping approaches in human, mice and zebrafish : expert overview of the EU cost action gemstone ('GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork')

Ines Foessl, J. H. Duncan Bassett, Åshild Bjørnerem, Björn Busse, Ângelo Calado, Pascale Chavassieux, Maria Christou, Eleni Douni, Imke A. K. Fiedler, João Eurico Fonseca, et al.

(2021) FRONTIERS IN ENDOCRINOLOGY. 12.

Author

Ines Foessl, J. H. Duncan Bassett, Åshild Bjørnerem, Björn Busse, Ângelo Calado, Pascale Chavassieux, Maria Christou, Eleni Douni, Imke A. K. Fiedler, João Eurico Fonseca, Eva Hassler, Wolfgang Högler, Erika Kague, David Karasik, Patricia Khashayar (UGent) , Bente L. Langdahl, Victoria D. Leitch, Philippe Lopes, Georgios Markozannes, Fiona E. A. McGuigan, Carolina Medina-Gomez, Evangelia Ntzani, Ling Oei, Claes Ohlsson, Pawel Szulc, Jonathan H. Tobias, Katerina Trajanoska, Şansın Tuzun, Amina Valjevac, Bert van Rietbergen, Graham R. Williams, Tatjana Zekic, Fernando Rivadeneira and Barbara Obermayer-Pietsch

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Abstract

A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal Traits translational Network”) Working Group 2 present an overview of the routine techniques as well as clinical and research approaches employed to characterize bone phenotypes in humans and selected animal models (mice and zebrafish) of health and disease. The goal is consolidation of knowledge and a map for future research. This expert paper provides a comprehensive overview of state-of-the-art technologies to investigate bone properties in humans and animals – including their strengths and weaknesses. New research methodologies are outlined and future strategies are discussed to combine phenotypic with rapidly developing –omics data in order to advance musculoskeletal research and move towards “personalised medicine”.

Keywords

Endocrinology, Diabetes and Metabolism, bone and skeletal diseases, phenotyping, imaging, animal models, GEMSTONECOST, QUANTITATIVE COMPUTED-TOMOGRAPHY, REFERENCE POINT INDENTATION, MINERALIZATION DENSITY DISTRIBUTION, VERTEBRAL FRACTURE ASSESSMENT, BRANCHIAL ARCH MUTANTS, X-RAY ABSORPTIOMETRY, IN-VIVO ASSESSMENT, MECHANICAL-PROPERTIES, TURNOVER MARKERS, HIP FRACTURE

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Citation

Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8728625

MLA: Foessl, Ines, et al. “Bone Phenotyping Approaches in Human, Mice and Zebrafish : Expert Overview of the EU Cost Action Gemstone ('GEnomics of MusculoSkeletal Traits TranslatiOnal NEtwork’).” FRONTIERS IN ENDOCRINOLOGY, vol. 12, 2021, doi:10.3389/fendo.2021.720728.
APA: Foessl, I., Bassett, J. H. D., Bjørnerem, Å., Busse, B., Calado, Â., Chavassieux, P., … Obermayer-Pietsch, B. (2021). Bone phenotyping approaches in human, mice and zebrafish : expert overview of the EU cost action gemstone ('GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork’). FRONTIERS IN ENDOCRINOLOGY, 12. https://doi.org/10.3389/fendo.2021.720728
Chicago author-date: Foessl, Ines, J. H. Duncan Bassett, Åshild Bjørnerem, Björn Busse, Ângelo Calado, Pascale Chavassieux, Maria Christou, et al. 2021. “Bone Phenotyping Approaches in Human, Mice and Zebrafish : Expert Overview of the EU Cost Action Gemstone ('GEnomics of MusculoSkeletal Traits TranslatiOnal NEtwork’).” FRONTIERS IN ENDOCRINOLOGY 12. https://doi.org/10.3389/fendo.2021.720728.
Chicago author-date (all authors): Foessl, Ines, J. H. Duncan Bassett, Åshild Bjørnerem, Björn Busse, Ângelo Calado, Pascale Chavassieux, Maria Christou, Eleni Douni, Imke A. K. Fiedler, João Eurico Fonseca, Eva Hassler, Wolfgang Högler, Erika Kague, David Karasik, Patricia Khashayar, Bente L. Langdahl, Victoria D. Leitch, Philippe Lopes, Georgios Markozannes, Fiona E. A. McGuigan, Carolina Medina-Gomez, Evangelia Ntzani, Ling Oei, Claes Ohlsson, Pawel Szulc, Jonathan H. Tobias, Katerina Trajanoska, Şansın Tuzun, Amina Valjevac, Bert van Rietbergen, Graham R. Williams, Tatjana Zekic, Fernando Rivadeneira, and Barbara Obermayer-Pietsch. 2021. “Bone Phenotyping Approaches in Human, Mice and Zebrafish : Expert Overview of the EU Cost Action Gemstone ('GEnomics of MusculoSkeletal Traits TranslatiOnal NEtwork’).” FRONTIERS IN ENDOCRINOLOGY 12. doi:10.3389/fendo.2021.720728.
Vancouver: 1.
Foessl I, Bassett JHD, Bjørnerem Å, Busse B, Calado Â, Chavassieux P, et al. Bone phenotyping approaches in human, mice and zebrafish : expert overview of the EU cost action gemstone ('GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork’). FRONTIERS IN ENDOCRINOLOGY. 2021;12.
IEEE: [1]
I. Foessl et al., “Bone phenotyping approaches in human, mice and zebrafish : expert overview of the EU cost action gemstone ('GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork’),” FRONTIERS IN ENDOCRINOLOGY, vol. 12, 2021.

@article{8728625,
  abstract     = {{A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal Traits translational Network”) Working Group 2 present an overview of the routine techniques as well as clinical and research approaches employed to characterize bone phenotypes in humans and selected animal models (mice and zebrafish) of health and disease. The goal is consolidation of knowledge and a map for future research. This expert paper provides a comprehensive overview of state-of-the-art technologies to investigate bone properties in humans and animals – including their strengths and weaknesses. New research methodologies are outlined and future strategies are discussed to combine phenotypic with rapidly developing –omics data in order to advance musculoskeletal research and move towards “personalised medicine”.}},
  articleno    = {{720728}},
  author       = {{Foessl, Ines and Bassett, J. H. Duncan and Bjørnerem, Åshild and Busse, Björn and Calado, Ângelo and Chavassieux, Pascale and Christou, Maria and Douni, Eleni and Fiedler, Imke A. K. and Fonseca, João Eurico and Hassler, Eva and Högler, Wolfgang and Kague, Erika and Karasik, David and Khashayar, Patricia and Langdahl, Bente L. and Leitch, Victoria D. and Lopes, Philippe and Markozannes, Georgios and McGuigan, Fiona E. A. and Medina-Gomez, Carolina and Ntzani, Evangelia and Oei, Ling and Ohlsson, Claes and Szulc, Pawel and Tobias, Jonathan H. and Trajanoska, Katerina and Tuzun, Şansın and Valjevac, Amina and van Rietbergen, Bert and Williams, Graham R. and Zekic, Tatjana and Rivadeneira, Fernando and Obermayer-Pietsch, Barbara}},
  issn         = {{1664-2392}},
  journal      = {{FRONTIERS IN ENDOCRINOLOGY}},
  keywords     = {{Endocrinology,Diabetes and Metabolism,bone and skeletal diseases,phenotyping,imaging,animal models,GEMSTONECOST,QUANTITATIVE COMPUTED-TOMOGRAPHY,REFERENCE POINT INDENTATION,MINERALIZATION DENSITY DISTRIBUTION,VERTEBRAL FRACTURE ASSESSMENT,BRANCHIAL ARCH MUTANTS,X-RAY ABSORPTIOMETRY,IN-VIVO ASSESSMENT,MECHANICAL-PROPERTIES,TURNOVER MARKERS,HIP FRACTURE}},
  language     = {{eng}},
  pages        = {{32}},
  title        = {{Bone phenotyping approaches in human, mice and zebrafish : expert overview of the EU cost action gemstone ('GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork')}},
  url          = {{http://doi.org/10.3389/fendo.2021.720728}},
  volume       = {{12}},
  year         = {{2021}},
}

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Bone phenotyping approaches in human, mice and zebrafish : expert overview of the EU cost action gemstone ('GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork')

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