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African trypanosomosis obliterates DTPa vaccine-induced functional memory so that post-treatment Bordetella pertussis challenge fails to trigger a protective recall response

Magdalena Radwanska (UGent) , Thi Thu Hang Nguyen (UGent) and Stefan Magez (UGent)
(2021) VACCINES. 9(6).
Author
Organization
Abstract
Salivarian trypanosomes are extracellular parasites causing anthroponotic and zoonotic infections. Anti-parasite vaccination is considered the only sustainable method for global trypanosomosis control. Unfortunately, no single field applicable vaccine solution has been successful so far. The active destruction of the host's adaptive immune system by trypanosomes is believed to contribute to this problem. Here, we show that Trypanosome brucei brucei infection results in the lasting obliteration of immunological memory, including vaccine-induced memory against non-related pathogens. Using the well-established DTPa vaccine model in combination with a T. b. brucei infection and a diminazene diaceturate anti-parasite treatment scheme, our results demonstrate that while the latter ensured full recovery from the T. b. brucei infection, it failed to restore an efficacious anti-B. pertussis vaccine recall response. The DTPa vaccine failure coincided with a shift in the IgG1/IgG2a anti-B. pertussis antibody ratio in favor of IgG2a, and a striking impact on all of the spleen immune cell populations. Interestingly, an increased plasma IFN gamma level in DTPa-vaccinated trypanosome-infected mice coincided with a temporary antibody-independent improvement in early-stage trypanosomosis control. In conclusion, our results are the first to show that trypanosome-inflicted immune damage is not restored by successful anti-parasite treatment.
Keywords
VARIANT SURFACE GLYCOPROTEIN, NECROSIS-FACTOR-ALPHA, EVANSI INFECTION, MECHANICAL TRANSMISSION, GLOBAL DISTRIBUTION, BRUCEI-GAMBIENSE, IMMUNE-RESPONSE, ARMS-RACE, CONGOLENSE, IMMUNIZATION, trypanosomosis, treatment, DTPa, Bordetella pertussis

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Citation

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MLA
Radwanska, Magdalena, et al. “African Trypanosomosis Obliterates DTPa Vaccine-Induced Functional Memory so That Post-Treatment Bordetella Pertussis Challenge Fails to Trigger a Protective Recall Response.” VACCINES, vol. 9, no. 6, 2021, doi:10.3390/vaccines9060603.
APA
Radwanska, M., Nguyen, T. T. H., & Magez, S. (2021). African trypanosomosis obliterates DTPa vaccine-induced functional memory so that post-treatment Bordetella pertussis challenge fails to trigger a protective recall response. VACCINES, 9(6). https://doi.org/10.3390/vaccines9060603
Chicago author-date
Radwanska, Magdalena, Thi Thu Hang Nguyen, and Stefan Magez. 2021. “African Trypanosomosis Obliterates DTPa Vaccine-Induced Functional Memory so That Post-Treatment Bordetella Pertussis Challenge Fails to Trigger a Protective Recall Response.” VACCINES 9 (6). https://doi.org/10.3390/vaccines9060603.
Chicago author-date (all authors)
Radwanska, Magdalena, Thi Thu Hang Nguyen, and Stefan Magez. 2021. “African Trypanosomosis Obliterates DTPa Vaccine-Induced Functional Memory so That Post-Treatment Bordetella Pertussis Challenge Fails to Trigger a Protective Recall Response.” VACCINES 9 (6). doi:10.3390/vaccines9060603.
Vancouver
1.
Radwanska M, Nguyen TTH, Magez S. African trypanosomosis obliterates DTPa vaccine-induced functional memory so that post-treatment Bordetella pertussis challenge fails to trigger a protective recall response. VACCINES. 2021;9(6).
IEEE
[1]
M. Radwanska, T. T. H. Nguyen, and S. Magez, “African trypanosomosis obliterates DTPa vaccine-induced functional memory so that post-treatment Bordetella pertussis challenge fails to trigger a protective recall response,” VACCINES, vol. 9, no. 6, 2021.
@article{8733509,
  abstract     = {{Salivarian trypanosomes are extracellular parasites causing anthroponotic and zoonotic infections. Anti-parasite vaccination is considered the only sustainable method for global trypanosomosis control. Unfortunately, no single field applicable vaccine solution has been successful so far. The active destruction of the host's adaptive immune system by trypanosomes is believed to contribute to this problem. Here, we show that Trypanosome brucei brucei infection results in the lasting obliteration of immunological memory, including vaccine-induced memory against non-related pathogens. Using the well-established DTPa vaccine model in combination with a T. b. brucei infection and a diminazene diaceturate anti-parasite treatment scheme, our results demonstrate that while the latter ensured full recovery from the T. b. brucei infection, it failed to restore an efficacious anti-B. pertussis vaccine recall response. The DTPa vaccine failure coincided with a shift in the IgG1/IgG2a anti-B. pertussis antibody ratio in favor of IgG2a, and a striking impact on all of the spleen immune cell populations. Interestingly, an increased plasma IFN gamma level in DTPa-vaccinated trypanosome-infected mice coincided with a temporary antibody-independent improvement in early-stage trypanosomosis control. In conclusion, our results are the first to show that trypanosome-inflicted immune damage is not restored by successful anti-parasite treatment.}},
  articleno    = {{603}},
  author       = {{Radwanska, Magdalena and Nguyen, Thi Thu Hang and Magez, Stefan}},
  issn         = {{2076-393X}},
  journal      = {{VACCINES}},
  keywords     = {{VARIANT SURFACE GLYCOPROTEIN,NECROSIS-FACTOR-ALPHA,EVANSI INFECTION,MECHANICAL TRANSMISSION,GLOBAL DISTRIBUTION,BRUCEI-GAMBIENSE,IMMUNE-RESPONSE,ARMS-RACE,CONGOLENSE,IMMUNIZATION,trypanosomosis,treatment,DTPa,Bordetella pertussis}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{17}},
  title        = {{African trypanosomosis obliterates DTPa vaccine-induced functional memory so that post-treatment Bordetella pertussis challenge fails to trigger a protective recall response}},
  url          = {{http://doi.org/10.3390/vaccines9060603}},
  volume       = {{9}},
  year         = {{2021}},
}

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