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The influence of Ca/Mg ratio on autogelation of hydrogel biomaterials with bioceramic compounds

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Abstract
Hydrogels, which are versatile three-dimensional structures containing polymers and water, are very attractive for use in biomedical fields, but they suffer from rather weak mechanical properties. In this regard, biocompatible particles can be used to enhance their mechanical properties. The possibility of loading such particles with drugs (e.g. enzymes) makes them a particularly useful component in hydrogels. In this study, micro/nanoparticles containing various ratios of Ca2+/Mg2+ with sizes ranging from 1 to 8 mu m were prepared and mixed with gellan gum (GG) solution to study the in-situ formation of hydrogel-particle composites. The particles provide multiple functionalities: 1) they efficiently crosslink GG to induce hydrogel formation through the release of the divalent cations (Ca2+/Mg2+) known to bind to GG polymer chains; 2) they enhance mechanical properties of the hydrogel from 2 up to 100 kPa; 3) the samples most efficiently promoting cell growth were found to contain two types of minerals: vaterite and hydroxymagnesite, which enhanced cells proliferation and hydroxyapatite formation. The results demonstrate that such composite materials are attractive candidates for applications in bone regeneration.
Keywords
Caclium carbonate, Vaterite, Hydrogel, Cells, Gellification, Gellun gum, Osteogeneration, Ossification, Hydroxyapatite, DRUG-DELIVERY, BONE-GRAFTS, VATERITE, MICROPARTICLES, FILMS, MINERALIZATION, PARTICLES, RELEASE, REPAIR, CELLS

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Citation

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MLA
Abalymov, Anatolii, et al. “The Influence of Ca/Mg Ratio on Autogelation of Hydrogel Biomaterials with Bioceramic Compounds.” BIOMATERIALS ADVANCES, vol. 133, 2022, doi:10.1016/j.msec.2021.112632.
APA
Abalymov, A., Lengert, E., Van der Meeren, L., Saveleva, M., Ivanova, A., Douglas, T. E. L., … Parakhonskiy, B. (2022). The influence of Ca/Mg ratio on autogelation of hydrogel biomaterials with bioceramic compounds. BIOMATERIALS ADVANCES, 133. https://doi.org/10.1016/j.msec.2021.112632
Chicago author-date
Abalymov, Anatolii, Ekaterina Lengert, Louis Van der Meeren, Mariia Saveleva, Anna Ivanova, Timothy E. L. Douglas, Andre Skirtach, Dmitry Volodkin, and Bogdan Parakhonskiy. 2022. “The Influence of Ca/Mg Ratio on Autogelation of Hydrogel Biomaterials with Bioceramic Compounds.” BIOMATERIALS ADVANCES 133. https://doi.org/10.1016/j.msec.2021.112632.
Chicago author-date (all authors)
Abalymov, Anatolii, Ekaterina Lengert, Louis Van der Meeren, Mariia Saveleva, Anna Ivanova, Timothy E. L. Douglas, Andre Skirtach, Dmitry Volodkin, and Bogdan Parakhonskiy. 2022. “The Influence of Ca/Mg Ratio on Autogelation of Hydrogel Biomaterials with Bioceramic Compounds.” BIOMATERIALS ADVANCES 133. doi:10.1016/j.msec.2021.112632.
Vancouver
1.
Abalymov A, Lengert E, Van der Meeren L, Saveleva M, Ivanova A, Douglas TEL, et al. The influence of Ca/Mg ratio on autogelation of hydrogel biomaterials with bioceramic compounds. BIOMATERIALS ADVANCES. 2022;133.
IEEE
[1]
A. Abalymov et al., “The influence of Ca/Mg ratio on autogelation of hydrogel biomaterials with bioceramic compounds,” BIOMATERIALS ADVANCES, vol. 133, 2022.
@article{8746222,
  abstract     = {{Hydrogels, which are versatile three-dimensional structures containing polymers and water, are very attractive for use in biomedical fields, but they suffer from rather weak mechanical properties. In this regard, biocompatible particles can be used to enhance their mechanical properties. The possibility of loading such particles with drugs (e.g. enzymes) makes them a particularly useful component in hydrogels. In this study, micro/nanoparticles containing various ratios of Ca2+/Mg2+ with sizes ranging from 1 to 8 mu m were prepared and mixed with gellan gum (GG) solution to study the in-situ formation of hydrogel-particle composites. The particles provide multiple functionalities: 1) they efficiently crosslink GG to induce hydrogel formation through the release of the divalent cations (Ca2+/Mg2+) known to bind to GG polymer chains; 2) they enhance mechanical properties of the hydrogel from 2 up to 100 kPa; 3) the samples most efficiently promoting cell growth were found to contain two types of minerals: vaterite and hydroxymagnesite, which enhanced cells proliferation and hydroxyapatite formation. The results demonstrate that such composite materials are attractive candidates for applications in bone regeneration.}},
  articleno    = {{112632}},
  author       = {{Abalymov, Anatolii and Lengert, Ekaterina and Van der Meeren, Louis and Saveleva, Mariia and Ivanova, Anna and Douglas, Timothy E. L. and Skirtach, Andre and Volodkin, Dmitry and Parakhonskiy, Bogdan}},
  issn         = {{2772-9508}},
  journal      = {{BIOMATERIALS ADVANCES}},
  keywords     = {{Caclium carbonate,Vaterite,Hydrogel,Cells,Gellification,Gellun gum,Osteogeneration,Ossification,Hydroxyapatite,DRUG-DELIVERY,BONE-GRAFTS,VATERITE,MICROPARTICLES,FILMS,MINERALIZATION,PARTICLES,RELEASE,REPAIR,CELLS}},
  language     = {{eng}},
  pages        = {{10}},
  title        = {{The influence of Ca/Mg ratio on autogelation of hydrogel biomaterials with bioceramic compounds}},
  url          = {{http://doi.org/10.1016/j.msec.2021.112632}},
  volume       = {{133}},
  year         = {{2022}},
}

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