The influence of Ca/Mg ratio on autogelation of hydrogel biomaterials with bioceramic compounds
- Author
- Anatolii Abalymov, Ekaterina Lengert, Louis Van der Meeren (UGent) , Mariia Saveleva, Anna Ivanova, Timothy E. L. Douglas, Andre Skirtach (UGent) , Dmitry Volodkin and Bogdan Parakhonskiy (UGent)
- Organization
- Project
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- ERA-NET Rus Plus - INTELBIOCOMP (HybrBioScaf): vervaardiging en karakterisering va nieuwe hybridscaffolds met gecontroleerde porositeitshierarchie
- Composite hydrogel based materials modified with mineral particles and polyelectrolytes for tissue engineering
- Atomic force microscopy (AFM) - nanobiotechnology gebaseerd platform voor het bereiken van de dynamiek van afzonderlijke moleculen tot veelzijdige materialen en celmechanica
- EncapsuLatIon of FErropTotic cells into Immunogenic MicrocapsulEs: a deadly combination to cancer (LIFETIME)
- Controlled delivery of connexin43 mimetic peptide by nanocontainers for therapy of systemic inflammation
- Microscopy-computer connection and detection system
- Super Resolution stimulated Raman scattering imaging enabled by silicon photonics
- Innovation Hub for Surface and Colloid Biology Research
- Abstract
- Hydrogels, which are versatile three-dimensional structures containing polymers and water, are very attractive for use in biomedical fields, but they suffer from rather weak mechanical properties. In this regard, biocompatible particles can be used to enhance their mechanical properties. The possibility of loading such particles with drugs (e.g. enzymes) makes them a particularly useful component in hydrogels. In this study, micro/nanoparticles containing various ratios of Ca2+/Mg2+ with sizes ranging from 1 to 8 mu m were prepared and mixed with gellan gum (GG) solution to study the in-situ formation of hydrogel-particle composites. The particles provide multiple functionalities: 1) they efficiently crosslink GG to induce hydrogel formation through the release of the divalent cations (Ca2+/Mg2+) known to bind to GG polymer chains; 2) they enhance mechanical properties of the hydrogel from 2 up to 100 kPa; 3) the samples most efficiently promoting cell growth were found to contain two types of minerals: vaterite and hydroxymagnesite, which enhanced cells proliferation and hydroxyapatite formation. The results demonstrate that such composite materials are attractive candidates for applications in bone regeneration.
- Keywords
- Caclium carbonate, Vaterite, Hydrogel, Cells, Gellification, Gellun gum, Osteogeneration, Ossification, Hydroxyapatite, DRUG-DELIVERY, BONE-GRAFTS, VATERITE, MICROPARTICLES, FILMS, MINERALIZATION, PARTICLES, RELEASE, REPAIR, CELLS
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8746222
- MLA
- Abalymov, Anatolii, et al. “The Influence of Ca/Mg Ratio on Autogelation of Hydrogel Biomaterials with Bioceramic Compounds.” BIOMATERIALS ADVANCES, vol. 133, 2022, doi:10.1016/j.msec.2021.112632.
- APA
- Abalymov, A., Lengert, E., Van der Meeren, L., Saveleva, M., Ivanova, A., Douglas, T. E. L., … Parakhonskiy, B. (2022). The influence of Ca/Mg ratio on autogelation of hydrogel biomaterials with bioceramic compounds. BIOMATERIALS ADVANCES, 133. https://doi.org/10.1016/j.msec.2021.112632
- Chicago author-date
- Abalymov, Anatolii, Ekaterina Lengert, Louis Van der Meeren, Mariia Saveleva, Anna Ivanova, Timothy E. L. Douglas, Andre Skirtach, Dmitry Volodkin, and Bogdan Parakhonskiy. 2022. “The Influence of Ca/Mg Ratio on Autogelation of Hydrogel Biomaterials with Bioceramic Compounds.” BIOMATERIALS ADVANCES 133. https://doi.org/10.1016/j.msec.2021.112632.
- Chicago author-date (all authors)
- Abalymov, Anatolii, Ekaterina Lengert, Louis Van der Meeren, Mariia Saveleva, Anna Ivanova, Timothy E. L. Douglas, Andre Skirtach, Dmitry Volodkin, and Bogdan Parakhonskiy. 2022. “The Influence of Ca/Mg Ratio on Autogelation of Hydrogel Biomaterials with Bioceramic Compounds.” BIOMATERIALS ADVANCES 133. doi:10.1016/j.msec.2021.112632.
- Vancouver
- 1.Abalymov A, Lengert E, Van der Meeren L, Saveleva M, Ivanova A, Douglas TEL, et al. The influence of Ca/Mg ratio on autogelation of hydrogel biomaterials with bioceramic compounds. BIOMATERIALS ADVANCES. 2022;133.
- IEEE
- [1]A. Abalymov et al., “The influence of Ca/Mg ratio on autogelation of hydrogel biomaterials with bioceramic compounds,” BIOMATERIALS ADVANCES, vol. 133, 2022.
@article{8746222, abstract = {{Hydrogels, which are versatile three-dimensional structures containing polymers and water, are very attractive for use in biomedical fields, but they suffer from rather weak mechanical properties. In this regard, biocompatible particles can be used to enhance their mechanical properties. The possibility of loading such particles with drugs (e.g. enzymes) makes them a particularly useful component in hydrogels. In this study, micro/nanoparticles containing various ratios of Ca2+/Mg2+ with sizes ranging from 1 to 8 mu m were prepared and mixed with gellan gum (GG) solution to study the in-situ formation of hydrogel-particle composites. The particles provide multiple functionalities: 1) they efficiently crosslink GG to induce hydrogel formation through the release of the divalent cations (Ca2+/Mg2+) known to bind to GG polymer chains; 2) they enhance mechanical properties of the hydrogel from 2 up to 100 kPa; 3) the samples most efficiently promoting cell growth were found to contain two types of minerals: vaterite and hydroxymagnesite, which enhanced cells proliferation and hydroxyapatite formation. The results demonstrate that such composite materials are attractive candidates for applications in bone regeneration.}}, articleno = {{112632}}, author = {{Abalymov, Anatolii and Lengert, Ekaterina and Van der Meeren, Louis and Saveleva, Mariia and Ivanova, Anna and Douglas, Timothy E. L. and Skirtach, Andre and Volodkin, Dmitry and Parakhonskiy, Bogdan}}, issn = {{2772-9508}}, journal = {{BIOMATERIALS ADVANCES}}, keywords = {{Caclium carbonate,Vaterite,Hydrogel,Cells,Gellification,Gellun gum,Osteogeneration,Ossification,Hydroxyapatite,DRUG-DELIVERY,BONE-GRAFTS,VATERITE,MICROPARTICLES,FILMS,MINERALIZATION,PARTICLES,RELEASE,REPAIR,CELLS}}, language = {{eng}}, pages = {{10}}, title = {{The influence of Ca/Mg ratio on autogelation of hydrogel biomaterials with bioceramic compounds}}, url = {{http://doi.org/10.1016/j.msec.2021.112632}}, volume = {{133}}, year = {{2022}}, }
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