Distinct immune profiles of HIV‐infected subjects are linked to specific lipid mediator signature
- Author
- Magdalena Sips (UGent) , Sarah Gerlo (UGent) , Laura De Clercq, Esteban A. Gomez, Romain A. Colas, Jesmond Dalli and Linos Vandekerckhove (UGent)
- Organization
- Project
- Abstract
- Introduction: To date, with no prophylactic human immunodeficiency virus (HIV) vaccine available, HIV incidence rates remain undefeated. Despite full virological suppression, HIV+ individuals exhibit a higher rate of cardiovascular disorders and cancers what is attributed to the residual, persistent levels of immune activation. Methods: We have established the Virological and Immunological Monitoring (VIM) platform and forty VIM samples that included treated immunological responders (IRs) or nonresponders (INRs), viremic untreated subjects and uninfected controls, were phenotyped by flow cytometry and plasma was used to quantify proinflammatory eicosanoids and the specialized proresolving mediators by liquid chromatography tandem mass spectrometry. Results: While HIV infection profoundly altered lipid mediator (LM) profile, differences were also seen in patients on viral suppressive therapy. IRs exhibited higher levels of proresolving mediators as compared to INRs and notable differences in plasma LM were also seen in early and late treated individuals. Conclusions: This study demonstrated distortions in proinflammatory/proresolution processes in infected patients including those with controlled viremia.
- Keywords
- Immunology, Immunology and Allergy, human, infections, inflammation, lipid mediators, viral/retroviral, INFLAMMATION, OIL
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8758911
- MLA
- Sips, Magdalena, et al. “Distinct Immune Profiles of HIV‐infected Subjects Are Linked to Specific Lipid Mediator Signature.” IMMUNITY INFLAMMATION AND DISEASE, vol. 10, no. 6, 2022, doi:10.1002/iid3.629.
- APA
- Sips, M., Gerlo, S., De Clercq, L., Gomez, E. A., Colas, R. A., Dalli, J., & Vandekerckhove, L. (2022). Distinct immune profiles of HIV‐infected subjects are linked to specific lipid mediator signature. IMMUNITY INFLAMMATION AND DISEASE, 10(6). https://doi.org/10.1002/iid3.629
- Chicago author-date
- Sips, Magdalena, Sarah Gerlo, Laura De Clercq, Esteban A. Gomez, Romain A. Colas, Jesmond Dalli, and Linos Vandekerckhove. 2022. “Distinct Immune Profiles of HIV‐infected Subjects Are Linked to Specific Lipid Mediator Signature.” IMMUNITY INFLAMMATION AND DISEASE 10 (6). https://doi.org/10.1002/iid3.629.
- Chicago author-date (all authors)
- Sips, Magdalena, Sarah Gerlo, Laura De Clercq, Esteban A. Gomez, Romain A. Colas, Jesmond Dalli, and Linos Vandekerckhove. 2022. “Distinct Immune Profiles of HIV‐infected Subjects Are Linked to Specific Lipid Mediator Signature.” IMMUNITY INFLAMMATION AND DISEASE 10 (6). doi:10.1002/iid3.629.
- Vancouver
- 1.Sips M, Gerlo S, De Clercq L, Gomez EA, Colas RA, Dalli J, et al. Distinct immune profiles of HIV‐infected subjects are linked to specific lipid mediator signature. IMMUNITY INFLAMMATION AND DISEASE. 2022;10(6).
- IEEE
- [1]M. Sips et al., “Distinct immune profiles of HIV‐infected subjects are linked to specific lipid mediator signature,” IMMUNITY INFLAMMATION AND DISEASE, vol. 10, no. 6, 2022.
@article{8758911,
abstract = {{Introduction: To date, with no prophylactic human immunodeficiency virus (HIV) vaccine available, HIV incidence rates remain undefeated. Despite full virological suppression, HIV+ individuals exhibit a higher rate of cardiovascular disorders and cancers what is attributed to the residual, persistent levels of immune activation.
Methods: We have established the Virological and Immunological Monitoring (VIM) platform and forty VIM samples that included treated immunological responders (IRs) or nonresponders (INRs), viremic untreated subjects and uninfected controls, were phenotyped by flow cytometry and plasma was used to quantify proinflammatory eicosanoids and the specialized proresolving mediators by liquid chromatography tandem mass spectrometry.
Results: While HIV infection profoundly altered lipid mediator (LM) profile, differences were also seen in patients on viral suppressive therapy. IRs exhibited higher levels of proresolving mediators as compared to INRs and notable differences in plasma LM were also seen in early and late treated individuals.
Conclusions: This study demonstrated distortions in proinflammatory/proresolution processes in infected patients including those with controlled viremia.}},
articleno = {{e629}},
author = {{Sips, Magdalena and Gerlo, Sarah and De Clercq, Laura and Gomez, Esteban A. and Colas, Romain A. and Dalli, Jesmond and Vandekerckhove, Linos}},
issn = {{2050-4527}},
journal = {{IMMUNITY INFLAMMATION AND DISEASE}},
keywords = {{Immunology,Immunology and Allergy,human,infections,inflammation,lipid mediators,viral/retroviral,INFLAMMATION,OIL}},
language = {{eng}},
number = {{6}},
pages = {{9}},
title = {{Distinct immune profiles of HIV‐infected subjects are linked to specific lipid mediator signature}},
url = {{http://doi.org/10.1002/iid3.629}},
volume = {{10}},
year = {{2022}},
}
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