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Clinicopathological characteristics and disease chronicity in native kidney biopsies in Flanders

(2023) CLINICAL KIDNEY JOURNAL. 16(1). p.125-137
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Abstract
Lay Summary The Flemish Collaborative Glomerulonephritis Group (FCGG) registry collects information on patients that undergo kidney biopsy in the region of Flanders in Belgium. The registry summarizes the underlying diagnoses in patients that present with symptoms of kidney disease (e.g. blood and/or protein in the urine or decreased kidney function). Additionally, the registry also collects information on the degree of chronic damage on kidney biopsy. This is important because chronic damage may lead to kidney failure. From 2017 until 2019, a total of 2054 adult biopsies were analyzed, while chronic damage could be analyzed in 898 biopsies. We found that the underlying causes of severe kidney disease were similar to studies performed in other European countries. Importantly, we found that increasing age, reduced kidney function and certain diagnoses are associated with more chronic damage on kidney biopsy. This information may be useful to doctors in clinical practice, in both Belgium and Europe. Background The Flemish Collaborative Glomerulonephritis Group (FCGG) registry provides complete population data on kidney disease epidemiology in the region of Flanders (Belgium), as it captures all native kidney biopsies performed in its population of 6.5 million inhabitants. Methods From 2017 until 2019, 2054 adult kidney biopsies were included from 26 nephrology centers (one biopsy per patient). Data on nephrotic and nephritic syndrome were available in 1992 and 2026 biopsies, respectively. In a subgroup of 898 biopsies containing >= 10 glomeruli from 2018 to 2019, disease chronicity was graded using the Mayo Clinic Chronicity Score (MCCS). The association between clinical variables and MCCS was determined using simple and multiple linear regression models. Results Nephrotic syndrome (present in 378 patients, 19.0%) was most frequently caused by minimal change disease in younger patients (18-44 years), membranous nephropathy in older patients (45-74 years) and amyloidosis in the elderly (>75 years). Nephritic syndrome (present in 421 patients, 20.8%) was most frequently caused by immunoglobulin A nephropathy (IgAN) in younger patients (18-64 years) and ANCA-associated vasculitis (AAV) in older patients (>64 years). AAV and IgAN were the most frequent underlying diagnoses in biopsies in which crescents were identified. In multivariable analysis, acute and chronic kidney disease and diagnoses of diabetic kidney disease, nephrosclerosis and hyperoxaluria/hypercalcemic nephropathy were associated with the highest MCCS increases. Conclusions The FCGG registry validates data from previous Western European registries and provides a snapshot of disease chronicity in the whole biopsied Flemish population.
Keywords
Transplantation, Nephrology, registry, MCCS, kidney biopsy, epidemiology, chronicity

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MLA
Deleersnijder, Dries, et al. “Clinicopathological Characteristics and Disease Chronicity in Native Kidney Biopsies in Flanders.” CLINICAL KIDNEY JOURNAL, vol. 16, no. 1, 2023, pp. 125–37, doi:10.1093/ckj/sfac208.
APA
Deleersnijder, D., Laurens, W., De Meester, J., Cleenders, E., Dendooven, A., Lerut, E., … FCGG collaborative group, [missing]. (2023). Clinicopathological characteristics and disease chronicity in native kidney biopsies in Flanders. CLINICAL KIDNEY JOURNAL, 16(1), 125–137. https://doi.org/10.1093/ckj/sfac208
Chicago author-date
Deleersnijder, Dries, Wim Laurens, Johan De Meester, Evert Cleenders, Amélie Dendooven, Evelyne Lerut, An De Vriese, et al. 2023. “Clinicopathological Characteristics and Disease Chronicity in Native Kidney Biopsies in Flanders.” CLINICAL KIDNEY JOURNAL 16 (1): 125–37. https://doi.org/10.1093/ckj/sfac208.
Chicago author-date (all authors)
Deleersnijder, Dries, Wim Laurens, Johan De Meester, Evert Cleenders, Amélie Dendooven, Evelyne Lerut, An De Vriese, Tom Dejagere, Mark Helbert, Rachel Hellemans, Priyanka Koshy, Bart Maes, Lissa Pipeleers, Amaryllis H Van Craenenbroeck, Steven Van Laecke, Johan Vande Walle, Marie M Couttenye, Gert Meeus, Ben Sprangers, Anja De Rycke, Anne-Marie Bogaert, Annemie Woestenburg, Bart Denys, Domien Peeters, Hilde Vanbelleghem, Jan Donck, Johan Scharpé, Nele De Clippeleir, Ann Colson, Karen Meyvis, Kurt Vandepitte, Liza-Maria Reyns, Jacques Peeters, Marc Decupere, Miranda Zeegers, Nathalie Neirynck, Pascale Bernaert, Tom Dejagere, Wim Lemahieu, Noël Knops, Elena Levtchenko, Sevasti Karamaria, Koen Van Hoeck, Dominique Trouet, Reiner Maul, Anne Hoorens, Jo Van Dorpe, Marleen Praet, Caroline Geers, Priyanka Koshy, Tania Roskams, Selda Aydin, Vasiliki Siozopoulou, Anne-Marie Schelfhout, Hendrik De Raeve, Edwin Steenkiste, Francesca Dedeurwaerdere, Ignace Dalle, Kristof Cokelaere, Stijn Deloose, Pascale De Paepe, Peter Van Eyken, and [missing] FCGG collaborative group. 2023. “Clinicopathological Characteristics and Disease Chronicity in Native Kidney Biopsies in Flanders.” CLINICAL KIDNEY JOURNAL 16 (1): 125–137. doi:10.1093/ckj/sfac208.
Vancouver
1.
Deleersnijder D, Laurens W, De Meester J, Cleenders E, Dendooven A, Lerut E, et al. Clinicopathological characteristics and disease chronicity in native kidney biopsies in Flanders. CLINICAL KIDNEY JOURNAL. 2023;16(1):125–37.
IEEE
[1]
D. Deleersnijder et al., “Clinicopathological characteristics and disease chronicity in native kidney biopsies in Flanders,” CLINICAL KIDNEY JOURNAL, vol. 16, no. 1, pp. 125–137, 2023.
@article{8766608,
  abstract     = {{Lay Summary The Flemish Collaborative Glomerulonephritis Group (FCGG) registry collects information on patients that undergo kidney biopsy in the region of Flanders in Belgium. The registry summarizes the underlying diagnoses in patients that present with symptoms of kidney disease (e.g. blood and/or protein in the urine or decreased kidney function). Additionally, the registry also collects information on the degree of chronic damage on kidney biopsy. This is important because chronic damage may lead to kidney failure. From 2017 until 2019, a total of 2054 adult biopsies were analyzed, while chronic damage could be analyzed in 898 biopsies. We found that the underlying causes of severe kidney disease were similar to studies performed in other European countries. Importantly, we found that increasing age, reduced kidney function and certain diagnoses are associated with more chronic damage on kidney biopsy. This information may be useful to doctors in clinical practice, in both Belgium and Europe.

Background The Flemish Collaborative Glomerulonephritis Group (FCGG) registry provides complete population data on kidney disease epidemiology in the region of Flanders (Belgium), as it captures all native kidney biopsies performed in its population of 6.5 million inhabitants. Methods From 2017 until 2019, 2054 adult kidney biopsies were included from 26 nephrology centers (one biopsy per patient). Data on nephrotic and nephritic syndrome were available in 1992 and 2026 biopsies, respectively. In a subgroup of 898 biopsies containing >= 10 glomeruli from 2018 to 2019, disease chronicity was graded using the Mayo Clinic Chronicity Score (MCCS). The association between clinical variables and MCCS was determined using simple and multiple linear regression models. Results Nephrotic syndrome (present in 378 patients, 19.0%) was most frequently caused by minimal change disease in younger patients (18-44 years), membranous nephropathy in older patients (45-74 years) and amyloidosis in the elderly (>75 years). Nephritic syndrome (present in 421 patients, 20.8%) was most frequently caused by immunoglobulin A nephropathy (IgAN) in younger patients (18-64 years) and ANCA-associated vasculitis (AAV) in older patients (>64 years). AAV and IgAN were the most frequent underlying diagnoses in biopsies in which crescents were identified. In multivariable analysis, acute and chronic kidney disease and diagnoses of diabetic kidney disease, nephrosclerosis and hyperoxaluria/hypercalcemic nephropathy were associated with the highest MCCS increases. Conclusions The FCGG registry validates data from previous Western European registries and provides a snapshot of disease chronicity in the whole biopsied Flemish population.}},
  author       = {{Deleersnijder, Dries and Laurens, Wim and De Meester, Johan and Cleenders, Evert and Dendooven, Amélie and Lerut, Evelyne and De Vriese, An and Dejagere, Tom and Helbert, Mark and Hellemans, Rachel and Koshy, Priyanka and Maes, Bart and Pipeleers, Lissa and Van Craenenbroeck, Amaryllis H and Van Laecke, Steven and Vande Walle, Johan and Couttenye, Marie M and Meeus, Gert and Sprangers, Ben and De Rycke, Anja and Bogaert, Anne-Marie and Woestenburg, Annemie and Denys, Bart and Peeters, Domien and Vanbelleghem, Hilde and Donck, Jan and Scharpé, Johan and De Clippeleir, Nele and Colson, Ann and Meyvis, Karen and Vandepitte, Kurt and Reyns, Liza-Maria and Peeters, Jacques and Decupere, Marc and Zeegers, Miranda and Neirynck, Nathalie and Bernaert, Pascale and Dejagere, Tom and Lemahieu, Wim and Knops, Noël and Levtchenko, Elena and Karamaria, Sevasti and Van Hoeck, Koen and Trouet, Dominique and Maul, Reiner and Hoorens, Anne and Van Dorpe, Jo and Praet, Marleen and Geers, Caroline and Koshy, Priyanka and Roskams, Tania and Aydin, Selda and Siozopoulou, Vasiliki and Schelfhout, Anne-Marie and De Raeve, Hendrik and Steenkiste, Edwin and Dedeurwaerdere, Francesca and Dalle, Ignace and Cokelaere, Kristof and Deloose, Stijn and De Paepe, Pascale and Van Eyken, Peter and FCGG collaborative group, [missing]}},
  issn         = {{2048-8505}},
  journal      = {{CLINICAL KIDNEY JOURNAL}},
  keywords     = {{Transplantation,Nephrology,registry,MCCS,kidney biopsy,epidemiology,chronicity}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{125--137}},
  title        = {{Clinicopathological characteristics and disease chronicity in native kidney biopsies in Flanders}},
  url          = {{http://doi.org/10.1093/ckj/sfac208}},
  volume       = {{16}},
  year         = {{2023}},
}

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