Abstract
Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly. Thus, the accurate detection of senescent cells, especially in vivo, is essential. Here, we present a consensus from the International Cell Senescence Association (ICSA), defining and discussing key cellular and molecular features of senescence and offering recommendations on how to use them as biomarkers. We also present a resource tool to facilitate the identification of genes linked with senescence, SeneQuest (available at http://Senequest.net). Lastly, we propose an algorithm to accurately assess and quantify senescence, both in cultured cells and in vivo.
Original language | English |
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Pages (from-to) | 813-827 |
Number of pages | 15 |
Journal | Cell |
Volume | 179 |
Issue number | 4 |
DOIs | |
Publication status | Published - 31 Oct 2019 |
Funding
We would like to thank Nikolaos Kastrinakis, Panagiotis V.S. Vasileiou, Gkikas Magiorkinis, Eleni Fitsiou, and Michela Borghesan for their valuable support to this work. We apologize in advance that, for reason of space, we have omitted the citations of relevant papers and reviews. M.D. is funded by the Dutch Cancer Foundation , Netherlands (grant ID 10989 ). V.G., K.E., and K.V. were financially supported by the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grants agreement no. 722729 (SYNTRAIN); the Welfare Foundation for Social & Cultural Sciences (KIKPE), Greece; the KIKPE Foundation , Athens, Greece; Pentagon Biotechnology , UK; DeepMed IO , UK; grant no. 775 from the Hellenic Foundation for Research and Innovation (HFRI) ; and NKUA-SARG grants 70/3/9816 , 70/3/12128 , and 70/3/15603 . M.S.: is funded by the IRB and by grants from the Spanish Ministry of Economy co-funded by the European Regional Development Fund (ERDF) ( SAF2013-48256-R ), the European Research Council ( ERC-2014-AdG/669622 ), and “laCaixa” Foundation.
Funders | Funder number |
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Arlene Kogod Center on Aging | |
Cleara Biotech | |
KIKPE | |
KIKPE Foundation | 775 |
Unity Biotechnology | |
Welfare Foundation for Social & Cultural Sciences | |
Mayo Clinic | |
Horizon 2020 Framework Programme | 683136, 669622 |
Cancer Couch Foundation | ID 10989 |
European Research Council | |
Horizon 2020 | 722729 |
European Regional Development Fund | SAF2013-48256-R |
Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España | |
Hellenic Foundation for Research and Innovation | 70/3/15603, 70/3/12128, 70/3/9816 |
“laCaixa” Foundation |