Cellular Senescence: Defining a Path Forward

Vassilis Gorgoulis*, Peter D. Adams, Andrea Alimonti, Dorothy C. Bennett, Oliver Bischof, Cleo Bishop, Judith Campisi, Manuel Collado, Konstantinos Evangelou, Gerardo Ferbeyre, Jesús Gil, Eiji Hara, Valery Krizhanovsky, Diana Jurk, Andrea B. Maier, Masashi Narita, Laura Niedernhofer, João F. Passos, Paul D. Robbins, Clemens A. SchmittJohn Sedivy, Konstantinos Vougas, Thomas von Zglinicki, Daohong Zhou, Manuel Serrano, Marco Demaria

*Corresponding author for this work

Research output: Contribution to JournalReview articleAcademicpeer-review

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Abstract

Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly. Thus, the accurate detection of senescent cells, especially in vivo, is essential. Here, we present a consensus from the International Cell Senescence Association (ICSA), defining and discussing key cellular and molecular features of senescence and offering recommendations on how to use them as biomarkers. We also present a resource tool to facilitate the identification of genes linked with senescence, SeneQuest (available at http://Senequest.net). Lastly, we propose an algorithm to accurately assess and quantify senescence, both in cultured cells and in vivo.

Original languageEnglish
Pages (from-to)813-827
Number of pages15
JournalCell
Volume179
Issue number4
DOIs
Publication statusPublished - 31 Oct 2019

Funding

We would like to thank Nikolaos Kastrinakis, Panagiotis V.S. Vasileiou, Gkikas Magiorkinis, Eleni Fitsiou, and Michela Borghesan for their valuable support to this work. We apologize in advance that, for reason of space, we have omitted the citations of relevant papers and reviews. M.D. is funded by the Dutch Cancer Foundation , Netherlands (grant ID 10989 ). V.G., K.E., and K.V. were financially supported by the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grants agreement no. 722729 (SYNTRAIN); the Welfare Foundation for Social & Cultural Sciences (KIKPE), Greece; the KIKPE Foundation , Athens, Greece; Pentagon Biotechnology , UK; DeepMed IO , UK; grant no. 775 from the Hellenic Foundation for Research and Innovation (HFRI) ; and NKUA-SARG grants 70/3/9816 , 70/3/12128 , and 70/3/15603 . M.S.: is funded by the IRB and by grants from the Spanish Ministry of Economy co-funded by the European Regional Development Fund (ERDF) ( SAF2013-48256-R ), the European Research Council ( ERC-2014-AdG/669622 ), and “laCaixa” Foundation.

FundersFunder number
Arlene Kogod Center on Aging
Cleara Biotech
KIKPE
KIKPE Foundation775
Unity Biotechnology
Welfare Foundation for Social & Cultural Sciences
Mayo Clinic
Horizon 2020 Framework Programme683136, 669622
Cancer Couch FoundationID 10989
European Research Council
Horizon 2020722729
European Regional Development FundSAF2013-48256-R
Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España
Hellenic Foundation for Research and Innovation70/3/15603, 70/3/12128, 70/3/9816
“laCaixa” Foundation

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