IL-4 and IL-13 mediated down-regulation of CD8 expression levels can dampen anti-viral CD8⁺ T cell avidity following HIV-1 recombinant pox viral vaccination
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Wijesundara, Danushka K; Jackson, Ronald J; Tscharke, David C; Ranasinghe, Charani
Description
We have shown that mucosal HIV-1 recombinant pox viral vaccination can induce high, avidity HIV-specific CD8(+) T cells with reduced interleukin (IL)-4 and IL-13 expression compared to, systemic vaccine delivery. In the current study how these cytokines act to regulate anti-viral CD8(+) T, cell avidity following HIV-1 recombinant pox viral prime-boost vaccination was investigated. Out of a panel of T cell avidity markers tested, only CD8 expression levels were found to be enhanced on,...[Show more]
Collections | ANU Research Publications |
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Date published: | 2013-08-06 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/12930 |
Source: | Vaccine |
DOI: | 10.1016/j.vaccine.2013.07.062 |
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File | Description | Size | Format | Image |
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Danushka...Tscharke, D. C. et al IL-4 and IL-13 mediated down-regulation 2013.pdf | 345.39 kB | Adobe PDF |
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