Platelet factor 4 mediates inflammation in experimental cerebral malaria
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Srivastava, Kalyan; Cockburn, Ian; Swaim, Anne Marie; Thompson, Laura E; Tripathi, Abhai; Fletcher, Craig A; Shirk, Erin M; Sun, Henry; Kowalska, Anna M; Fox-Talbot, Karen; Sullivan, David; Zavala, Fidel; Morrell, Craig N
Description
Cerebral malaria (CM) is a major complication of Plasmodium falciparum infection in children. The pathogenesis of CM involves vascular inflammation, immune stimulation, and obstruction of cerebral capillaries. Platelets have a prominent role in both immune responses and vascular obstruction. We now demonstrate that the platelet-derived chemokine, platelet factor 4 (PF4)/CXCL4, promotes the development of experimental cerebral malaria (ECM). Plasmodium-infected red blood cells (RBCs) activated...[Show more]
Collections | ANU Research Publications |
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Date published: | 2008 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/33873 |
Source: | Cell Host and Microbe |
DOI: | 10.1016/j.chom.2008.07.003 |
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01_Srivastava_Platelet_factor_4_mediates_2008.pdf | 797.57 kB | Adobe PDF | Request a copy |
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