The Ig-like domain of human GM-CSF receptor α plays a critical role in cytokine binding and receptor activation
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Mirza, Shamaruh; Walker, Andrew; Chen, Jinglong; Murphy, James M; Young, Ian
Description
GM-CSF (granulocyte/macrophage colony-stimulating factor) is an important mediator of inducible haemopoiesis and inflammation, and has a critical role in the function of alveolar macrophages. Its clinical applications include the mobilization of haemopoietic progenitors, and a role as an immune stimulant and vaccine adjuvant in cancer patients. GM-CSF signals via a specific α receptor (GM-CSFRα) and the shared hβc (human common β-subunit). The present study has investigated the role of the...[Show more]
Collections | ANU Research Publications |
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Date published: | 2010 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/49890 |
Source: | Biochemical Journal |
DOI: | 10.1042/BJ20091745 |
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01_Mirza_The_Ig-like_domain_of_human_2010.pdf | 1.28 MB | Adobe PDF | Request a copy |
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