Proteins within the intracellular calcium store determine cardiac RyR channel activity and cardiac output
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Dulhunty, Angela; Wium, Elize; Li, Linwei; Hanna, Amy; Mirza, Shamaruh; Talukder, Sadik; Ghazali, Nuur; Beard, Nicole
Description
The contractile function of the heart requires the release of Ca2+ from intracellular Ca2+ stores in the sarcoplasmic reticulum (SR) of cardiac muscle cells. The efficacy of Ca2+ release depends on the amount of Ca2+ loaded into the Ca2+ store and the way in which this 'Ca2+ load' influences the activity of the cardiac ryanodine receptor Ca2+ release channel (RyR2). The effects of the Ca2+ load on Ca2+ release through RyR2 are facilitated by: (i) the sensitivity of RyR2 itself to luminal Ca2+...[Show more]
Collections | ANU Research Publications |
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Date published: | 2012 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/54552 |
Source: | Clinical and Experimental Pharmacology and Physiology |
DOI: | 10.1111/j.1440-1681.2012.05704.x |
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01_Dulhunty_Proteins_within_the_2012.pdf | 3.17 MB | Adobe PDF | Request a copy |
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