Efficacy of external tetraethylammonium block of the KcsA potassium channel: Molecular and Brownian dynamics studies
-
Altmetric Citations
Description
Blockade of the KcsA potassium channel by externally applied tetraethylammonium is investigated using molecular dynamics calculations and Brownian dynamics simulations. In KcsA, the aromatic rings of four tyrosine residues located just external to the selectivity filter create an attractive energy well or a binding cage for a tetraethylammonium molecule. We first investigate the effects of re-orienting the four tyrosine residues such that the centers of the aromatic rings face the...[Show more]
Collections | ANU Research Publications |
---|---|
Date published: | 2008 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/60953 |
Source: | Biochimica et Biophysica Acta: Biomembranes |
DOI: | 10.1016/j.bbamem.2008.05.008 |
Download
File | Description | Size | Format | Image |
---|---|---|---|---|
01_Bisset_Efficacy_of_external_2008.pdf | 921.31 kB | Adobe PDF | Request a copy |
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.
Updated: 17 November 2022/ Responsible Officer: University Librarian/ Page Contact: Library Systems & Web Coordinator