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Human DNA polymerase-η, an A-T mutator in somatic hypermutation of rearranged immunoglobulin genes, is a reverse transcriptase

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Franklin, Andrew; Milburn, Peter J; Blanden, Robert; Steele, Edward J

Description

We have proposed previously that error-prone reverse transcription using pre-mRNA of rearranged immunoglobulin variable (IgV) regions as templates is involved in the antibody diversifying mechanism of somatic hypermutation (SHM). As patients deficient in

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
URI: http://hdl.handle.net/1885/78292
Source: Immunology and Cell Biology
DOI: 10.1046/j.0818-9641.2004.01221.x

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