Human DNA polymerase-η, an A-T mutator in somatic hypermutation of rearranged immunoglobulin genes, is a reverse transcriptase
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Franklin, Andrew; Milburn, Peter J; Blanden, Robert; Steele, Edward J
Description
We have proposed previously that error-prone reverse transcription using pre-mRNA of rearranged immunoglobulin variable (IgV) regions as templates is involved in the antibody diversifying mechanism of somatic hypermutation (SHM). As patients deficient in
Collections | ANU Research Publications |
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Date published: | 2004 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/78292 |
Source: | Immunology and Cell Biology |
DOI: | 10.1046/j.0818-9641.2004.01221.x |
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