Persistent URL of this record https://hdl.handle.net/1887/133085
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The nucleosome: From structure to function through physics
control and modulate the access to the genetic material. The necessary amount of DNA
compaction is achieved via multiple levels of structural organization, the first being the
nucleosome – a unique complex of histone proteins with ~ 150 base pairs of DNA. Here
we use specific examples to demonstrate that many aspects of the structure and function
of nucleosomes can be understood using principles of basic physics, physics-based tools and
models. For instance, the stability of single nucleosomes and the accessibility to their DNA
depends sensitively on the charges of the histones that in turn can be changed by post-
translational modifications. The positions of nucleosomes along DNA molecules depend on
the sequence-dependent shape and elasticity of the DNA double helix that has to be wrapped
into the nucleosome complex. Larger-scale structures composed of...Show moreEukaryotic cells must fit meters of DNA into micron-sized cell nuclei and, at the same time,
control and modulate the access to the genetic material. The necessary amount of DNA
compaction is achieved via multiple levels of structural organization, the first being the
nucleosome – a unique complex of histone proteins with ~ 150 base pairs of DNA. Here
we use specific examples to demonstrate that many aspects of the structure and function
of nucleosomes can be understood using principles of basic physics, physics-based tools and
models. For instance, the stability of single nucleosomes and the accessibility to their DNA
depends sensitively on the charges of the histones that in turn can be changed by post-
translational modifications. The positions of nucleosomes along DNA molecules depend on
the sequence-dependent shape and elasticity of the DNA double helix that has to be wrapped
into the nucleosome complex. Larger-scale structures composed of multiple nucleosomes, i.e.
nucleosome arrays, depend in turn on the interactions between its constituents that result
from delicately tuned electrostatics.
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- All authors
- Onufriev, A.V.; Schiessel, H.
- Date
- 2019-01-30
- Volume
- 56
- Pages
- 119 - 130