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http://hdl.handle.net/1942/2785
Title: | Spatial determination of successive spikes in the isolated cat duodenum | Authors: | Lammers, WJEP FAES, Christel Stephen, B BIJNENS, Luc Ver Donck, LV Schuurkes, JAJ |
Issue Date: | 2004 | Publisher: | BLACKWELL PUBLISHING LTD | Source: | NEUROGASTROENTEROLOGY AND MOTILITY, 16(6). p. 775-783 | Abstract: | In seven isolated segments of the feline duodenum, the timings of all spikes and the locations of all spike patches that occurred after 12-16 successive slow waves were analysed. Simultaneous recordings were performed during 1-min periods using 240 extracellular electrodes (24 x 10 array; interelectrode distance 2 mm) positioned onto the serosal surface. In all seven preparations, spikes always occurred during the first half of the slow wave cycle. From preparation to preparation, and within 1-min periods in each preparation, there was limited variation in the spike-spike intervals, in the times between the spikes and the preceding slow wave and in the number of spikes at each electrode site. In contrast, the number of electrode sites that recorded spikes and the number of spike patches both showed great variability between preparations and sometimes within a single preparation. In addition, the location of spikes and spike patches was not random but was significantly concentrated in certain areas, often located along the anti-mesenteric border, while other sites showed little or no spike activity. In conclusion, spikes and spike patches tend to occur significantly in some areas and not in others. This spatial heterogeneity will play a role in intestinal motility. | Notes: | UAE Univ, Fac Med & Hlth Sci, Dept Physiol, Al Ain, U Arab Emirates. Limburgs Univ Ctr, Ctr Stat, Diepenbeek, Belgium. Johnson & Johnson Pharmaceut Res & Dev, Dept Biometr & Reporting, Beerse, Belgium. Johnson & Johnson Pharmaceut Res & Dev, Dept Gastrointestinal Pharmacol, Beerse, Belgium.Lammers, WJEP, UAE Univ, Fac Med & Hlth Sci, Dept Physiol, POB 17666, Al Ain, U Arab Emirates.wlammers@smoothmap.org | Keywords: | electrical mapping; slow wave; spatial statistics; spike patches; spikes | Document URI: | http://hdl.handle.net/1942/2785 | ISSN: | 1350-1925 | e-ISSN: | 1365-2982 | DOI: | 10.1111/j.1365-2982.2004.00578.x | ISI #: | 000225836700012 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2006 |
Appears in Collections: | Research publications |
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