- Title
- The effect of haemorrhagic shock and resuscitation on fracture healing in a rabbit model: An animal study
- Creator
- Brady, J.; Hardy, B. M.; Yoshino, O.; Buxton, A.; Quail, A.; Balogh, Z. J.
- Relation
- Bone and Joint Journal Vol. 100B, Issue 9, p. 1234-1240
- Publisher Link
- http://dx.doi.org/10.1302/0301-620X.100B9.BJJ-2017-1531.R1
- Publisher
- British Editorial Society of Bone and Joint Surgery
- Resource Type
- journal article
- Date
- 2018
- Description
- Aims: Little is known about the effect of haemorrhagic shock and resuscitation on fracture healing. This study used a rabbit model with a femoral osteotomy and fixation to examine this relationship. Materials and Methods: A total of 18 male New Zealand white rabbits underwent femoral osteotomy with intramedullary fixation with ‘shock’ (n = 9) and control (n = 9) groups. Shock was induced in the study group by removal of 35% of the total blood volume 45 minutes before resuscitation with blood and crystalloid. Fracture healing was monitored for eight weeks using serum markers of healing and radiographs. Results: Four animals were excluded due to postoperative complications. The serum concentration of osteocalcin was significantly elevated in the shock group postoperatively (p < 0.0001). There were otherwise no differences with regard to serum markers of bone healing. The callus index was consistently increased in the shock group on anteroposterior (p = 0.0069) and lateral (p = 0.0165) radiographs from three weeks postoperatively. The control group showed an earlier decrease of callus index. Radiographic scores were significantly greater in the control group (p = 0.0025). Conclusion: In a rabbit femoral osteotomy model with intramedullary fixation, haemorrhagic shock and resuscitation produced larger callus but with evidence of delayed remodelling.
- Subject
- trauma; shock; femur fracture; fracture healing; intramedullary nailing; organ failure
- Identifier
- http://hdl.handle.net/1959.13/1442332
- Identifier
- uon:41656
- Identifier
- ISSN:2049-4394
- Language
- eng
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