- Title
- Bioavailability of arsenic, cadmium, lead and mercury as measured by intestinal permeability
- Creator
- Bolan, Shiv; Seshadri, Balaji; Keely, Simon; Kunhikrishnan, Anitha; Bruce, Jessica; Grainge, Ian; Talley, Nicholas J.; Naidu, Ravi
- Relation
- Scientific Reports Vol. 11, Issue 1, no. 14675
- Publisher Link
- http://dx.doi.org/10.1038/s41598-021-94174-9
- Publisher
- Nature Publishing Group
- Resource Type
- journal article
- Date
- 2021
- Description
- In this study, the intestinal permeability of metal(loid)s (MLs) such as arsenic (As), cadmium (Cd), lead (Pb) and mercury (Hg) was examined, as influenced by gut microbes and chelating agents using an in vitro gastrointestinal/Caco-2 cell intestinal epithelium model. The results showed that in the presence of gut microbes or chelating agents, there was a significant decrease in the permeability of MLs (As-7.5%, Cd-6.3%, Pb-7.9% and Hg-8.2%) as measured by apparent permeability coefficient value (Papp), with differences in ML retention and complexation amongst the chelants and the gut microbes. The decrease in ML permeability varied amongst the MLs. Chelating agents reduce intestinal absorption of MLs by forming complexes thereby making them less permeable. In the case of gut bacteria, the decrease in the intestinal permeability of MLs may be associated to a direct protection of the intestinal barrier against the MLs or indirect intestinal ML sequestration by the gut bacteria through adsorption on bacterial surface. Thus, both gut microbes and chelating agents can be used to decrease the intestinal permeability of MLs, thereby mitigating their toxicity.
- Subject
- arsenic; cadmium; lead; mercury; intestinal permeability
- Identifier
- http://hdl.handle.net/1959.13/1448551
- Identifier
- uon:43435
- Identifier
- ISSN:2045-2322
- Rights
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2021
- Language
- eng
- Full Text
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