Article

Cerebrocortical Beta Activity in Overweight Humans Responds to Insulin Detemir

Author(s) / Creator(s)

Tschritter, Otto
Hennige, Anita M.
Preissl, Hubert
Porubska, Katarina
Schäfer, Silke A.
Lutzenberger, Werner
Machicao, Fausto
Birbaumer, Niels
Fritsche, Andreas
Häring, Hans-Ulrich

Abstract / Description

Background Insulin stimulates cerebrocortical beta and theta activity in lean humans. This effect is reduced in obese individuals indicating cerebrocortical insulin resistance. In the present study we tested whether insulin detemir is a suitable tool to restore the cerebral insulin response in overweight humans. This approach is based on studies in mice where we could recently demonstrate increased brain tissue concentrations of insulin and increased insulin signaling in the hypothalamus and cerebral cortex following peripheral injection of insulin detemir. Methodology/Principal Findings We studied activity of the cerebral cortex using magnetoencephalography in 12 lean and 34 overweight non-diabetic humans during a 2-step hyperinsulinemic euglycemic clamp (each step 90 min) with human insulin (HI) and saline infusion (S). In 10 overweight subjects we additionally performed the euglycemic clamp with insulin detemir (D). While human insulin administration did not change cerebrocortical activity relative to saline (p = 0.90) in overweight subjects, beta activity increased during D administration (basal 59±3 fT, 1st step 62±3 fT, 2nd step 66±5, p = 0.001, D vs. HI). As under this condition glucose infusion rates were lower with D than with HI (p = 0.003), it can be excluded that the cerebral effect is the consequence of a systemic effect. The total effect of insulin detemir on beta activity was not different from the human insulin effect in lean subjects (p = 0.78). Conclusions/Significance Despite cerebrocortical resistance to human insulin, insulin detemir increased beta activity in overweight human subjects similarly as human insulin in lean subjects. These data suggest that the decreased cerebral beta activity response in overweight subjects can be restored by insulin detemir.

Keyword(s)

Übergewicht Langsames Hirnpotenzial Insulinresistenz Übergewicht Langsames Hirnpotenzial Insulinresistenz insulin resistance cerebrocortical beta activity insulin detemir experiment overweight humans MEG

Persistent Identifier

Date of first publication

2007

Publication status

unknown

Review status

unknown

Citation

  • Author(s) / Creator(s)
    Tschritter, Otto
  • Author(s) / Creator(s)
    Hennige, Anita M.
  • Author(s) / Creator(s)
    Preissl, Hubert
  • Author(s) / Creator(s)
    Porubska, Katarina
  • Author(s) / Creator(s)
    Schäfer, Silke A.
  • Author(s) / Creator(s)
    Lutzenberger, Werner
  • Author(s) / Creator(s)
    Machicao, Fausto
  • Author(s) / Creator(s)
    Birbaumer, Niels
  • Author(s) / Creator(s)
    Fritsche, Andreas
  • Author(s) / Creator(s)
    Häring, Hans-Ulrich
  • PsychArchives acquisition timestamp
    2022-11-22T06:49:52Z
  • Made available on
    2008-08-08
  • Made available on
    2015-12-01T10:32:16Z
  • Made available on
    2022-11-22T06:49:52Z
  • Date of first publication
    2007
  • Abstract / Description
    Background Insulin stimulates cerebrocortical beta and theta activity in lean humans. This effect is reduced in obese individuals indicating cerebrocortical insulin resistance. In the present study we tested whether insulin detemir is a suitable tool to restore the cerebral insulin response in overweight humans. This approach is based on studies in mice where we could recently demonstrate increased brain tissue concentrations of insulin and increased insulin signaling in the hypothalamus and cerebral cortex following peripheral injection of insulin detemir. Methodology/Principal Findings We studied activity of the cerebral cortex using magnetoencephalography in 12 lean and 34 overweight non-diabetic humans during a 2-step hyperinsulinemic euglycemic clamp (each step 90 min) with human insulin (HI) and saline infusion (S). In 10 overweight subjects we additionally performed the euglycemic clamp with insulin detemir (D). While human insulin administration did not change cerebrocortical activity relative to saline (p = 0.90) in overweight subjects, beta activity increased during D administration (basal 59±3 fT, 1st step 62±3 fT, 2nd step 66±5, p = 0.001, D vs. HI). As under this condition glucose infusion rates were lower with D than with HI (p = 0.003), it can be excluded that the cerebral effect is the consequence of a systemic effect. The total effect of insulin detemir on beta activity was not different from the human insulin effect in lean subjects (p = 0.78). Conclusions/Significance Despite cerebrocortical resistance to human insulin, insulin detemir increased beta activity in overweight human subjects similarly as human insulin in lean subjects. These data suggest that the decreased cerebral beta activity response in overweight subjects can be restored by insulin detemir.
    en
  • Publication status
    unknown
  • Review status
    unknown
  • ISSN
    1932-6203
  • Persistent Identifier
    https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bsz:291-psydok-21523
  • Persistent Identifier
    https://hdl.handle.net/20.500.11780/1151
  • Persistent Identifier
    https://doi.org/10.23668/psycharchives.11309
  • Language of content
    eng
  • Is part of
    PLoS ONE 2(11): e1196. doi:10.1371/journal.pone.0001196
  • Keyword(s)
    Übergewicht
    de
  • Keyword(s)
    Langsames Hirnpotenzial
    de
  • Keyword(s)
    Insulinresistenz
    de
  • Keyword(s)
    Übergewicht
    de
  • Keyword(s)
    Langsames Hirnpotenzial
    de
  • Keyword(s)
    Insulinresistenz
    de
  • Keyword(s)
    insulin resistance
    en
  • Keyword(s)
    cerebrocortical beta activity
    en
  • Keyword(s)
    insulin detemir
    en
  • Keyword(s)
    experiment
    en
  • Keyword(s)
    overweight humans
    en
  • Keyword(s)
    MEG
    en
  • Dewey Decimal Classification number(s)
    150
  • Title
    Cerebrocortical Beta Activity in Overweight Humans Responds to Insulin Detemir
    en
  • DRO type
    article
  • Visible tag(s)
    PsyDok