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Abstract:

Putrescine uptake in Trypanosoma cruzi epimastigotes is 10 to 50-fold higher than in Leishmania mexicana or Crithidia fasciculata. Polyamine transport in all these trypanosomatids is an energy-dependent process strongly inhibited by the presence of 2,4-dinitrophenol or KCN. Putrescine uptake in T. cruzi and L. mexicana was markedly decreased by the proton ionophore carbonylcyanide m-chlorophenylhydrazone but it was not affected by ouabain, a Na+-K+ pump inhibitor. The depletion of intracellular polyamines by treatment of parasite cultures with α-difluoromethylornithine elicited a marked induction of putrescine uptake in L. mexicana and C. fasciculata by increasing considerably the Vmax of this process. Conversely, the uptake of putrescine in T. cruzi was essentially unchanged by the same treatment. The differential regulation of putrescine transport in T. cruzi might be related to some distinctive features of polyamine metabolism in this parasite. © 1992.

Registro:

Documento: Artículo
Título:Differential regulation of putrescine uptake in trypanosoma cruzi and other trypanosomatids
Autor:Gonzalez, N.S.; Ceriani, C.; Algranati, I.D.
Filiación:Instituto de Investigaciones Bioquímicas Fundación Campomar, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, A. Machado 151, 1405 Buenos Aires, Argentina
Palabras clave:2,4 dinitrophenol; carbonyl cyanide chlorophenylhydrazone; potassium cyanide; putrescine; amine transport; article; epimastigote; leishmania mexicana; nonhuman; priority journal; trypanosoma cruzi; Animal; Biological Transport; Crithidia fasciculata; Eflornithine; Homeostasis; Kinetics; Leishmania mexicana; Putrescine; Support, Non-U.S. Gov't; Temperature; Trypanosoma cruzi; Crithidia fasciculata; Leishmania mexicana; Strophanthus gratus; Trypanosoma; Trypanosoma cruzi; Trypanosomatidae
Año:1992
Volumen:188
Número:1
Página de inicio:120
Página de fin:128
DOI: http://dx.doi.org/10.1016/0006-291X(92)92358-5
Título revista:Biochemical and Biophysical Research Communications
Título revista abreviado:Biochem. Biophys. Res. Commun.
ISSN:0006291X
CODEN:BBRCA
CAS:Eflornithine, 70052-12-9; Putrescine, 110-60-1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v188_n1_p120_Gonzalez

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Citas:

---------- APA ----------
Gonzalez, N.S., Ceriani, C. & Algranati, I.D. (1992) . Differential regulation of putrescine uptake in trypanosoma cruzi and other trypanosomatids. Biochemical and Biophysical Research Communications, 188(1), 120-128.
http://dx.doi.org/10.1016/0006-291X(92)92358-5
---------- CHICAGO ----------
Gonzalez, N.S., Ceriani, C., Algranati, I.D. "Differential regulation of putrescine uptake in trypanosoma cruzi and other trypanosomatids" . Biochemical and Biophysical Research Communications 188, no. 1 (1992) : 120-128.
http://dx.doi.org/10.1016/0006-291X(92)92358-5
---------- MLA ----------
Gonzalez, N.S., Ceriani, C., Algranati, I.D. "Differential regulation of putrescine uptake in trypanosoma cruzi and other trypanosomatids" . Biochemical and Biophysical Research Communications, vol. 188, no. 1, 1992, pp. 120-128.
http://dx.doi.org/10.1016/0006-291X(92)92358-5
---------- VANCOUVER ----------
Gonzalez, N.S., Ceriani, C., Algranati, I.D. Differential regulation of putrescine uptake in trypanosoma cruzi and other trypanosomatids. Biochem. Biophys. Res. Commun. 1992;188(1):120-128.
http://dx.doi.org/10.1016/0006-291X(92)92358-5