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Abstract:

Nifurtimox (NF) and benznidazole (BZ), drugs used in the treatment ofChagas' disease, did not inhibit protein biosynthesis in in vitro homologous cell-free systems isolated from Trypanosoma cruzi and Crithidia fasciculata; nevertheless, their addition to growing cultures caused polyribosomal depolymerization. On the other hand, Berenil®, Antrycide® and suramin, used against African trypanosomiasis, inhibited protein biosynthesis in vitro but did not affect ribosomal distribution, probably due to low permeability to the drugs. The results suggest that the inhibition by NF and BZ of protein synthesis, measured as [14C]leucine incorporation by other authors, is indirect, probably through inhibition of nucleic acid synthesis and energy metabolism. © 1989.

Registro:

Documento: Artículo
Título:Effects of trypanocidal drugs on protein biosynthesis in vitro and in vivo by Trypanosoma cruzi
Autor:Gonzalez, N.S.; Cazzulo, J.J.
Filiación:Instituto de Investigaciones Bioquimicas, Fundacion Campomar, Facultad de Ciencias Exactas y Naturales, 1405 Buenos Aires, Argentina
Palabras clave:benznidazole; diminazene aceturate; nifurtimox; quinapyramine; suramin; crithidia fasciculata; nonhuman; priority journal; protein synthesis; protein synthesis inhibition; protozoon; trypanosoma cruzi; Animal; Crithidia; In Vitro; Nifurtimox; Nitrofurans; Nitroimidazoles; Proteins; Trypanocidal Agents; Trypanosoma cruzi
Año:1989
Volumen:38
Número:17
Página de inicio:2873
Página de fin:2877
DOI: http://dx.doi.org/10.1016/0006-2952(89)90444-9
Título revista:Biochemical Pharmacology
Título revista abreviado:Biochem. Pharmacol.
ISSN:00062952
CODEN:BCPCA
CAS:benznidazole, 22994-85-0; diminazene aceturate, 908-54-3; nifurtimox, 23256-30-6; quinapyramine, 3270-78-8; suramin, 129-46-4, 145-63-1; benzonidazole, 22994-85-0; Nifurtimox, 23256-30-6; Nitrofurans; Nitroimidazoles; Proteins; Trypanocidal Agents
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00062952_v38_n17_p2873_Gonzalez

Referencias:

  • Goijman, Frasch, Stoppani, Efectos diferentes del nifurtimox y el benznidazol sobre la biosintesis de DNA, RNA y proteinas en Trypanosoma cruzi (1984) Medicina (Buenos Aires), 44, pp. 261-270
  • Polak, Richle, Mode of action of the 2-nitroimidazole derivative benznidazole (1978) Ann Trop Med Parasitol, 72, pp. 45-54
  • Gugliotta, Tanowitz, Wittner, Soeiro, Trypanosoma cruzi: inhibition of protein synthesis by nitrofuran SQ-18506 (1980) Exp Parasitol, 49, pp. 216-224
  • Sims, Gutteridge, Mode of action of a 5-nitrofuran drug (SQ 18506) against Trypanosoma cruzi (1978) International Journal for Parasitology, 9, pp. 61-67
  • Kahan, Zahalsky, Hutner, Protein synthesis in cell-free preparations of Crithidia fasciculata (1968) 3 Protozool, 15, pp. 385-390
  • Cazzulo, Franke de Cazzulo, Engel, Cannata, End products and enzyme levels of aerobic glucose fermentation in trypanosomatids (1985) Mol Biochem Parasitol, 16, pp. 329-343
  • Rao, Harman, Motten, Schreiber, Mason, Generation of radical anions of nitrofurantoin misonidazole and metronidazole by ascorbate (1987) Archives of Biochemistry and Biophysics, 225, pp. 419-427
  • Chesters, Protein synthesis by cell-free extracts of Crithidia oncopelti (1966) Biochim Biophys Acta, 114, pp. 385-397
  • Bacchi, Lambros, Goldberg, Hutner, de Carvalho, Susceptibility of an insect Leptomonas and Crithidia fasciculata to several established antitrypanosomatid agents (1974) Antimicrob Agents Chemother, 6, pp. 785-790
  • Gutteridge, Chemotherapy of Chagas'disease: the present situation (1976) Trop Dis Bull, 73, pp. 699-705
  • Gutteridge, Coombs, (1977) Biochemistry of Parasitic Protozoa, p. 139. , Macmillan Press, London

Citas:

---------- APA ----------
Gonzalez, N.S. & Cazzulo, J.J. (1989) . Effects of trypanocidal drugs on protein biosynthesis in vitro and in vivo by Trypanosoma cruzi. Biochemical Pharmacology, 38(17), 2873-2877.
http://dx.doi.org/10.1016/0006-2952(89)90444-9
---------- CHICAGO ----------
Gonzalez, N.S., Cazzulo, J.J. "Effects of trypanocidal drugs on protein biosynthesis in vitro and in vivo by Trypanosoma cruzi" . Biochemical Pharmacology 38, no. 17 (1989) : 2873-2877.
http://dx.doi.org/10.1016/0006-2952(89)90444-9
---------- MLA ----------
Gonzalez, N.S., Cazzulo, J.J. "Effects of trypanocidal drugs on protein biosynthesis in vitro and in vivo by Trypanosoma cruzi" . Biochemical Pharmacology, vol. 38, no. 17, 1989, pp. 2873-2877.
http://dx.doi.org/10.1016/0006-2952(89)90444-9
---------- VANCOUVER ----------
Gonzalez, N.S., Cazzulo, J.J. Effects of trypanocidal drugs on protein biosynthesis in vitro and in vivo by Trypanosoma cruzi. Biochem. Pharmacol. 1989;38(17):2873-2877.
http://dx.doi.org/10.1016/0006-2952(89)90444-9