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Abstract:

We evaluated the effect of circling training (CT) in the expression of muscarinic acetylcholine receptor (mAchR) in developing rat striatum. For this, male and female rats were subjected to CT at 20, 30, 40 and 60 days of age during 7 days. Animals trained at 30 days but not at other ages showed an average decreased binding to mAchR of 33% in males and 24% in females, representing a significant difference with respect to control non-trained animals (males P < 0.001, females P < 0.005), and showing also a differential response between sex (P < 0.01). mAchR drop was found invariably either 2 months or 1 year after training indicating a long term plastic change due to circling training. Scatchard analysis showed that altered binding represents a variation of the total receptor number instead of its binding affinity, with no significant differences found among Kd (P > 0.1). mAchR variation was correlated with the motor performance accomplished in the test. Regarding total distance run, male rats trained for 3 days (300 meters run), for 5 days (600 meters) and for 7 days (900 meters) showed a drop of 19, 28 and 33% respectively (r2 = 0.91, P < 0.001), while female changes were of 21, 23 and 24% (r2 = 0.78, P < 0.001). Nevertheless, no correlation with running speed was found (r2 = 0.13 male, r2 = 0.02 female; P > 0.1). In summary, these results demonstrate the presence of a limited sensitivity period during striatum development where mAchR expression may be affected by the activity performed during CT, representing a permanent alteration of the receptor levels. © 1995 Elsevier Science B.V. All rights reserved.

Registro:

Documento: Artículo
Título:Permanent alteration of muscarinic acetylcholine receptor binding in rat striatum after circling training during development
Autor:Ibarra, G.R.; Rodriguez, J.A.; Paratcha, G.Ch.; Azcurra, J.M.
Filiación:Laboratorio de Biologia Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 4 Piso Pabellon II. Ciudad Universitaria, 1428 Buenos Aires, Argentina
Palabras clave:Circling training; Development; Muscarinic receptor; Plasticity; Rat striatum; Receptor binding; muscarinic receptor; quinuclidinyl benzilate; adolescent; animal experiment; article; brain development; circling behavior; controlled study; female; male; nerve cell plasticity; nonhuman; priority journal; rat; receptor binding; sex difference; training; Age Factors; Animals; Behavior, Animal; Brain; Female; Male; Motor Activity; Neostriatum; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Sex Factors; Time Factors
Año:1995
Volumen:705
Número:1-2
Página de inicio:39
Página de fin:44
DOI: http://dx.doi.org/10.1016/0006-8993(95)01076-9
Título revista:Brain Research
Título revista abreviado:Brain Res.
ISSN:00068993
CODEN:BRREA
CAS:Receptors, Muscarinic
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00068993_v705_n1-2_p39_Ibarra

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Citas:

---------- APA ----------
Ibarra, G.R., Rodriguez, J.A., Paratcha, G.Ch. & Azcurra, J.M. (1995) . Permanent alteration of muscarinic acetylcholine receptor binding in rat striatum after circling training during development. Brain Research, 705(1-2), 39-44.
http://dx.doi.org/10.1016/0006-8993(95)01076-9
---------- CHICAGO ----------
Ibarra, G.R., Rodriguez, J.A., Paratcha, G.Ch., Azcurra, J.M. "Permanent alteration of muscarinic acetylcholine receptor binding in rat striatum after circling training during development" . Brain Research 705, no. 1-2 (1995) : 39-44.
http://dx.doi.org/10.1016/0006-8993(95)01076-9
---------- MLA ----------
Ibarra, G.R., Rodriguez, J.A., Paratcha, G.Ch., Azcurra, J.M. "Permanent alteration of muscarinic acetylcholine receptor binding in rat striatum after circling training during development" . Brain Research, vol. 705, no. 1-2, 1995, pp. 39-44.
http://dx.doi.org/10.1016/0006-8993(95)01076-9
---------- VANCOUVER ----------
Ibarra, G.R., Rodriguez, J.A., Paratcha, G.Ch., Azcurra, J.M. Permanent alteration of muscarinic acetylcholine receptor binding in rat striatum after circling training during development. Brain Res. 1995;705(1-2):39-44.
http://dx.doi.org/10.1016/0006-8993(95)01076-9