Artículo

Meresman, G.F.; Vighi, S.; Buquet, R.A.; Contreras-Ortiz, O.; Tesone, M.; Rumi, L.S. "Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis" (2000) Fertility and Sterility. 74(4):760-766
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Abstract:

Objective: To evaluate and compare spontaneous apoptosis and Bcl-2 and Bax expression in eutopic endometrium from women with and without endometriosis. Design: Apoptosis and Bcl-2 and Bax expression were examined in eutopic endometrium from women with and without endometriosis. Setting: Instituto de Biologia y Medicina Experimental-CONICET, Department of Gynecology and Department of Gynecological Pathology, Clinicas University Hospital, Buenos Aires, Argentina. Patient(s): Women with untreated endometriosis (n = 14) and controls (n = 16). Intervention(s): Collection of endometrial samples during diagnostic or therapeutic laparoscopy. Main Outcome Measure(s): Apoptotic cells were detected with use of the dUTP nick- end labeling (TUNEL) assay; Bcl-2 and Bax expressions were assessed with use of immunohistochemical techniques. Result(s): Spontaneous apoptosis was significantly lower in eutopic endometrium from patients with endometriosis, compared with healthy controls (2.26 ± 0.53 and 9.37 ± 1.69 apoptotic cells/field, respectively) and was independent of cycle phase. An increased expression of Bcl-2 protein was found in proliferative eutopic endometrium from patients with endometriosis. Bax expression was absent in proliferative endometrium, whereas there was an increase in its expression in secretory endometrium from both patients and controls. Conclusion(s): Women with endometriosis show decreased number of apoptotic cells in eutopic endometrium. The abnormal survival of endometrial cells may result in their continuing growth into ectopic locations. (C) 2000 by American Society for Reproductive Medicine.

Registro:

Documento: Artículo
Título:Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis
Autor:Meresman, G.F.; Vighi, S.; Buquet, R.A.; Contreras-Ortiz, O.; Tesone, M.; Rumi, L.S.
Filiación:Institute de Biología y Medicina Experimental (IBYME), Buenos Aires, Argentina
Department of Gynecological Pathology, Hospital de Clínicas José de San Martín, Buenos Aires, Argentina
Department of Gynecology, Hospital de Clínicas José de San Martin, Buenos Aires, Argentina
Instituto de Biología y Medicina Experimental, Vuelta de Obligado 2490, Buenos Aires, 1428, Argentina
Palabras clave:Apoptosis; Bax; Bcl-2; Endometriosis; Eutopic endometrium; protein Bax; protein bcl 2; apoptosis; article; clinical article; controlled study; endometriosis; female; human; human tissue; immunohistochemistry; laparoscopy; priority journal; protein expression; Apoptosis; Endometriosis; Endometrium; Female; Human; In Situ Hybridization; Menstrual Cycle; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Support, Non-U.S. Gov't
Año:2000
Volumen:74
Número:4
Página de inicio:760
Página de fin:766
DOI: http://dx.doi.org/10.1016/S0015-0282(00)01522-3
Título revista:Fertility and Sterility
Título revista abreviado:Fertil. Steril.
ISSN:00150282
CODEN:FESTA
CAS:Bax protein; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00150282_v74_n4_p760_Meresman

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Citas:

---------- APA ----------
Meresman, G.F., Vighi, S., Buquet, R.A., Contreras-Ortiz, O., Tesone, M. & Rumi, L.S. (2000) . Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis. Fertility and Sterility, 74(4), 760-766.
http://dx.doi.org/10.1016/S0015-0282(00)01522-3
---------- CHICAGO ----------
Meresman, G.F., Vighi, S., Buquet, R.A., Contreras-Ortiz, O., Tesone, M., Rumi, L.S. "Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis" . Fertility and Sterility 74, no. 4 (2000) : 760-766.
http://dx.doi.org/10.1016/S0015-0282(00)01522-3
---------- MLA ----------
Meresman, G.F., Vighi, S., Buquet, R.A., Contreras-Ortiz, O., Tesone, M., Rumi, L.S. "Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis" . Fertility and Sterility, vol. 74, no. 4, 2000, pp. 760-766.
http://dx.doi.org/10.1016/S0015-0282(00)01522-3
---------- VANCOUVER ----------
Meresman, G.F., Vighi, S., Buquet, R.A., Contreras-Ortiz, O., Tesone, M., Rumi, L.S. Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis. Fertil. Steril. 2000;74(4):760-766.
http://dx.doi.org/10.1016/S0015-0282(00)01522-3