Artículo

Recabarren, S.E.; Sir-Petermann, T.; Rios, R.; Maliqueo, M.; Echiburú, B.; Smith, R.; Rojas-García, P.; Recabarren, M.; Rey, R.A. "Pituitary and testicular function in sons of women with polycystic ovary syndrome from infancy to adulthood" (2008) Journal of Clinical Endocrinology and Metabolism. 93(9):3318-3324
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Abstract:

Context: An important proportion of male members of polycystic ovary syndrome (PCOS) families exhibit insulin resistance and related metabolic defects. However, the reproductive phenotypes in first-degree male relatives of PCOS women have been described less often. Objective: The objective of the study was to evaluate the pituitary-testicular function in sons of women with PCOS during different stages of life: early infancy, childhood, and adulthood. Design: Eighty sons of women with PCOS (PCOSS) and 56 sons of control women without hyperandrogenism (CS), matched for age, were studied. In all subjects, the pituitary-gonadal axis was evaluated by a GnRH agonist test (leuprolide acetate, 10 μg/kg sc). Serum anti-Müllerian hormone (AMH) and inhibin B were used as Sertoli cell markers. Serum concentrations of gonadotropins, steroid hormones, and SHBG were also determined. A semen analysis was performed. Results: Basal concentrations of gonadotropins, sex steroids, and inhibin B were comparable between PCOSs and CS during early infancy, childhood, and adulthood. Similar results in stimulated gonadotropin and sex steroid concentrations were observed. However, AMH serum concentrations were higher in PCOSs compared with CS during early infancy [925.0 (457.3-1401.7) vs. 685.6 (417.9-1313.2) pmol/liter, P = 0.039] and childhood [616.3 (304.6-1136.9) vs. 416.5 (206.7- 801.2) pmol/ liter, P = 0.007). Sperm-count analysis was similar between both groups. Conclusions: AMH concentrations are increased in prepubertal sons of women with PCOS, suggesting that these boys may show an increased Sertoli cell number or function during infancy and childhood. However, this does not seem to have a major deleterious effect on sperm production. Copyright © 2008 by The Endocrine Society.

Registro:

Documento: Artículo
Título:Pituitary and testicular function in sons of women with polycystic ovary syndrome from infancy to adulthood
Autor:Recabarren, S.E.; Sir-Petermann, T.; Rios, R.; Maliqueo, M.; Echiburú, B.; Smith, R.; Rojas-García, P.; Recabarren, M.; Rey, R.A.
Filiación:Laboratory of Animal Physiology and Endocrinology, Faculty of Veterinary Medicine, University of Concepción, 3801061 Chillán, Chile
Laboratory of Endocrinology and Metabolism West Division, School of Medicine, University of Chile, 8320000 Santiago, Chile
Institute of Maternal and Child Research, School of Medicine, University of Chile, 8360160 Santiago, Chile
Centro de Investigaciones Endocrinológicas, Hospital de Niños R. Gutiérrez, C1425EFD Buenos Aires, Argentina
Departamento de Histología, Biología Celular, Embriología, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
Laboratory of Endocrinology, Department of Medicine West Division, School of Medicine, L. P. 299, I. Quinta Norm., Casilla 33052, Correo 33, 8320000 Santiago, Chile
Palabras clave:cell marker; gonadotropin; inhibin B; leuprorelin; Muellerian inhibiting factor; steroid hormone; adolescent; adult; adulthood; analytic method; article; female; gonadotropin blood level; hormone blood level; human; hyperandrogenism; hypophysis function; hypothalamus hypophysis system; infancy; infant; major clinical study; male; nuclear family; ovary polycystic disease; prepuberty; priority journal; Sertoli cell; son; spermatozoon count; testis function
Año:2008
Volumen:93
Número:9
Página de inicio:3318
Página de fin:3324
DOI: http://dx.doi.org/10.1210/jc.2008-0255
Título revista:Journal of Clinical Endocrinology and Metabolism
Título revista abreviado:J. Clin. Endocrinol. Metab.
ISSN:0021972X
CODEN:JCEMA
CAS:gonadotropin, 63231-54-9; inhibin B, 115088-91-0; leuprorelin, 53714-56-0, 74381-53-6; Muellerian inhibiting factor, 80497-65-0
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0021972X_v93_n9_p3318_Recabarren

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Citas:

---------- APA ----------
Recabarren, S.E., Sir-Petermann, T., Rios, R., Maliqueo, M., Echiburú, B., Smith, R., Rojas-García, P.,..., Rey, R.A. (2008) . Pituitary and testicular function in sons of women with polycystic ovary syndrome from infancy to adulthood. Journal of Clinical Endocrinology and Metabolism, 93(9), 3318-3324.
http://dx.doi.org/10.1210/jc.2008-0255
---------- CHICAGO ----------
Recabarren, S.E., Sir-Petermann, T., Rios, R., Maliqueo, M., Echiburú, B., Smith, R., et al. "Pituitary and testicular function in sons of women with polycystic ovary syndrome from infancy to adulthood" . Journal of Clinical Endocrinology and Metabolism 93, no. 9 (2008) : 3318-3324.
http://dx.doi.org/10.1210/jc.2008-0255
---------- MLA ----------
Recabarren, S.E., Sir-Petermann, T., Rios, R., Maliqueo, M., Echiburú, B., Smith, R., et al. "Pituitary and testicular function in sons of women with polycystic ovary syndrome from infancy to adulthood" . Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 9, 2008, pp. 3318-3324.
http://dx.doi.org/10.1210/jc.2008-0255
---------- VANCOUVER ----------
Recabarren, S.E., Sir-Petermann, T., Rios, R., Maliqueo, M., Echiburú, B., Smith, R., et al. Pituitary and testicular function in sons of women with polycystic ovary syndrome from infancy to adulthood. J. Clin. Endocrinol. Metab. 2008;93(9):3318-3324.
http://dx.doi.org/10.1210/jc.2008-0255