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Abstract:

Mammary ductal morphogenesis during prepuberty occurs mainly in response to insulin-like growth factor-1 (IGF-1) and estradiol stimulation. Dairy heifers infected with gastrointestinal nematodes have reduced IGF-1 levels, accompanied by reduced growth rate, delayed puberty onset, and lower parenchyma-stroma relationship in their mammary glands. Immunohistochemical studies were undertaken to determine variations in cell division rate, IGF-1 system components, and estradiol receptors (ESR) during peripubertal development in the mammary glands of antiparasitic-treated and untreated Holstein heifers naturally infected with gastrointestinal nematodes. Mammary biopsies were taken at 20, 30, 40, and 70 wk of age. Proliferating cell nuclear antigen immunolabeling, evident in nuclei, tended to be higher in the parenchyma of the glands from treated heifers than in those from untreated. Insulin-like growth factor binding proteins (IGFBP) type 2 and type 3 immunolabeling was cytoplasmic and was evident in stroma and parenchyma. The IGFBP2-labeled area was lower in treated than in untreated heifers. In the treated group, a maximal expression of this protein was seen at 40 wk of age, whereas in the untreated group the labeling remained constant. No differences were observed for IGFBP3 between treatment groups or during development. Immunolabeling for α ESR (ESR1) was evident in parenchymal nuclei and was higher in treated than in untreated heifers. In the treated group, ESR1 peaked at 30 wk of age and then decreased. These results demonstrate that the parasite burden in young heifers negatively influence mammary gland development, affecting cell division rate and parameters related to estradiol and IGF-1 signaling in the gland. © 2014 American Dairy Science Association.

Registro:

Documento: Artículo
Título:Cellular proliferation rate and insulin-like growth factor binding protein (IGFBP)-2 and IGFBP-3 and estradiol receptor alpha expression in the mammary gland of dairy heifers naturally infected with gastrointestinal nematodes during development
Autor:Perri, A.F.; Dallard, B.E.; Baravalle, C.; Licoff, N.; Formía, N.; Ortega, H.H.; Becú-Villalobos, D.; Mejia, M.E.; Lacau-Mengido, I.M.
Filiación:Laboratorio de Regulación Hipofisaria, Instituto de Biología y Medicina Experimental, Vuelta de Obligado 2490, Ciudad Autónoma de Buenos Aires, 1428, Argentina
Facultad de Ciencias Veterinarias, Universidad Nacional del Litoral, 3080,Esperanza, Santa Fe, Argentina
Esc. Inchausti, Universidad Nacional de La Plata, 25 de mayo, 6667, Pcia. de Buenos Aires, Argentina
Palabras clave:Estradiol receptor alpha; Insulin-like growth factor binding protein; Prepubertal mammary gland; Proliferating cell nuclear antigen; anthelmintic agent; estradiol; estrogen receptor alpha; fenbendazole; ivermectin; levamisole; somatomedin binding protein 2; somatomedin binding protein 3; somatomedin C; animal; bovine; cell proliferation; controlled study; cytology; female; gastrointestinal tract; genetics; metabolism; nematode; nematodiasis; parasitology; randomized controlled trial; signal transduction; udder; veterinary; Animals; Anthelmintics; Cattle; Cell Proliferation; Estradiol; Estrogen Receptor alpha; Female; Fenbendazole; Gastrointestinal Tract; Insulin-Like Growth Factor Binding Protein 2; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Ivermectin; Levamisole; Mammary Glands, Animal; Nematoda; Nematode Infections; Signal Transduction
Año:2014
Volumen:97
Número:8
Página de inicio:4985
Página de fin:4996
DOI: http://dx.doi.org/10.3168/jds.2014-8070
Título revista:Journal of Dairy Science
Título revista abreviado:J. Dairy Sci.
ISSN:00220302
CAS:estradiol, 50-28-2; fenbendazole, 43210-67-9; ivermectin, 70288-86-7; levamisole, 14769-73-4, 16595-80-5; somatomedin C, 67763-96-6; Anthelmintics; Estradiol; Estrogen Receptor alpha; Fenbendazole; Insulin-Like Growth Factor Binding Protein 2; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Ivermectin; Levamisole
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00220302_v97_n8_p4985_Perri

Referencias:

  • Akers, R.M., Ellis, S.E., Berry, S.D., Ovarian and IGF-I axis control of mammary development in prepubertal heifers (2005) Domest. Anim. Endocrinol., 29, pp. 259-267
  • Akers, R.M., McFadden, T.B., Purup, S., Vestergaard, M., Sejrsen, K., Capuco, A.V., Local IGF-I axis in peripubertal ruminant mammary development (2000) J. Mammary Gland Biol. Neoplasia, 5, pp. 43-51
  • Arneberg, P., Folstad, I., Karter, A.J., Gastrointestinal nematodes depress food intake in naturally infected reindeer (1996) Parasitology, 112, pp. 213-219
  • Becú-Villalobos, D., Garcia-Tornadu, I., Shroeder, G., Salado, E.E., Gagliostro, G., Delavaud, C., Chilliard, Y., Lacau-Mengido, I.M., Effect of fat supplementation on leptin, insulin-like growth factor I, growth hormone, and insulin in cattle (2007) Can. J. Vet. Res., 71, pp. 218-225
  • Berry, S.D., Jobst, P.M., Ellis, S.E., Howard, R.D., Capuco, A.V., Akers, R.M., Mammary epithelial proliferation and estrogen receptor alpha expression in prepubertal heifers: Effects of ovariectomy and growth hormone (2003) J. Dairy Sci., 86, pp. 2098-2105
  • Berry, S.D., McFadden, T.B., Pearson, R.E., Akers, R.M., A local increase in the mammary IGF-1: IGFBP-3 ratio mediates the mammogenic effects of estrogen and growth hormone (2001) Domest. Anim. Endocrinol., 21, pp. 39-53
  • Blum, J.W., Baumrucker, C.R., Colostral and milk insulin-like growth factors and related substances: Mammary gland and neonatal (intestinal and systemic) targets (2002) Domest. Anim. Endocrinol., 23, pp. 101-110
  • Brown, E.G., VandeHaar, M.J., Daniels, K.M., Liesman, J.S., Chapin, L.T., Forrest, J.W., Akers, R.M., Nielsen, M.S., Effect of increasing energy and protein intake on mammary development in heifer calves (2005) J. Dairy Sci., 88, pp. 595-603
  • Capuco, A.V., Ellis, S., Bovine mammary progenitor cells: Current concepts and future directions (2005) J. Mammary Gland Biol. Neoplasia, 10, pp. 5-15
  • Capuco, A.V., Ellis, S., Wood, D.L., Akers, R.M., Garrett, W., Postnatal mammary ductal growth: Three-dimensional imaging of cell proliferation, effects of estrogen treatment, and expression of steroid receptors in prepubertal calves (2002) Tissue Cell, 34, pp. 143-154
  • Capuco, A.V., Smith, J.J., Waldo, D.R., Rexroad, C.E., Influence of prepubertal dietary regimen on mammary growth of Holstein heifers (1995) J. Dairy Sci., 78, pp. 2709-2725
  • Charlier, J., Duchateau, L., Claerebout, E., Vercruysse, J., Predicting milk-production responses after an autumn treatment of pastured dairy herds with eprinomectin (2007) Vet. Parasitol., 143, pp. 322-328
  • Connor, E.E., Wood, D.L., Sonstegard, T.S., da Mota, A.F., Bennett, G.L., Williams, J.L., Capuco, A.V., Chromosomal mapping and quantitative analysis of estrogen-related receptor alpha-1, estrogen receptors alpha and beta and progesterone receptor in the bovine mammary gland (2005) J. Endocrinol., 185, pp. 593-603
  • Cunha, G.R., Young, P., Hom, Y.K., Cooke, P.S., Taylor, J.A., Lubahn, D.B., Elucidation of a role for stromal steroid hormone receptors in mammary gland growth and development using tissue recombinants (1997) J. Mammary Gland Biol. Neoplasia, 2, pp. 393-402
  • Dallard, B.E., Baravalle, C., Andreotti, C., Ortega, H.H., Neder, V., Calvinho, L.F., Intramammary inoculation of Panax ginseng extract in cows at drying off enhances early mammary involution (2011) J. Dairy Res., 78, pp. 63-71
  • Dallard, B.E., Pujato, S.A., Baravalle, C., Pereyra, E.A., Rey, F., Renna, M.S., Calvinho, L.F., Intramammary infusion of Panax ginseng extract in the bovine mammary gland at cessation of milking modifies components of the insulin-like growth factor system during involution (2013) Res. Vet. Sci., 94, pp. 462-470
  • Dallard, B.E., Ruffino, V., Heffel, S., Calvinho, L.F., Effect of a biological response modifier on expression of growth factors and cellular proliferation at drying off (2007) J. Dairy Sci., 90, pp. 2229-2240
  • Davis Rincker, L.E., Weber Nielsen, M.S., Chapin, L.T., Liesman, J.S., Daniels, K.M., Akers, R.M., VandeHaar, M.J., Effects of feeding prepubertal heifers a high-energy diet for three, six, or twelve weeks on mammary growth and composition (2008) J. Dairy Sci., 91, pp. 1926-1935
  • Díaz-Torga, G.S., Mejía, M.E., González-Iglesias, A., Formía, N., Becú-Villalobos, D., Lacau-Mengido, I.M., Metabolic cues for puberty onset in free grazing Holstein heifers naturally infected with nematodes (2001) Theriogenology, 56, pp. 111-122
  • Dobos, R.C., Nandra, K.S., Riley, K., Fulkerson, W.J., Lean, I.J., Kellaway, R.C., The effect of dietary protein level during the pre-pubertal period of growth on mammary gland development and subsequent milk production in Friesian heifers (2000) Livest. Prod. Sci., 63, pp. 235-243
  • Farmer, C., Petitclerc, D., Sorensen, M.T., Vignola, M., Dourmad, J.Y., Impacts of dietary protein level and feed restriction during prepuberty on mammogenesis in gilts (2004) J. Anim. Sci., 82, pp. 2343-2351
  • (2010) Guide for the Care and Use of Agricultural Animals in Research and Teaching, , FASS, Federation of Animal Science Societies, Champaign, IL
  • Fendrick, J.L., Raafat, A.M., Haslam, S.Z., Mammary gland growth and development from the postnatal period to postmenopause: Ovarian steroid receptor ontogeny and regulation in the mouse (1998) J. Mammary Gland Biol. Neoplasia, 3, pp. 7-22
  • Forsyth, I.A., The mammary gland (1991) Baillieres Clin. Endocrinol. Metab., 5, pp. 809-832
  • Hadsell, D.L., Greenberg, N.M., Fligger, J.M., Baumrucker, C.R., Rosen, J.M., Targeted expression of des(1-3) human insulin-like growth factor I in transgenic mice influences mammary gland development and IGF-binding protein expression (1996) Endocrinology, 137, pp. 321-330
  • Haslam, S.Z., The ontogeny of mouse mammary gland responsiveness to ovarian steroid hormones (1989) Endocrinology, 125, pp. 2766-2772
  • Hinck, L., Silberstein, G.B., Key stages in mammary gland development: The mammary end bud as a motile organ (2005) Breast Cancer Res., 7, pp. 245-251
  • Hoeflich, A., Contrasting bone effects of temporary versus permanent IGFBP administration in rodents (2008) Growth Horm. IGF Res., 18, pp. 181-187
  • Holly, J.M., Perks, C.M., Insulin-like growth factor physiology: what we have learned from human studies (2012) Endocrinol. Metab. Clin. North Am., 41, pp. 249-263
  • Holmes, P.H., Pathophysiology of nematode infections (1987) Int. J. Parasitol., 17, pp. 443-451
  • Imagawa, W., Bandyopadhyay, G.K., Nandi, S., Regulation of mammary epithelial cell growth in mice and rats (1990) Endocr. Rev., 11, pp. 494-523
  • Imagawa, W., Pedchenko, V.K., Helber, J., Zhang, H., Hormone/growth factor interactions mediating epithelial/stromal communication in mammary gland development and carcinogenesis (2002) J. Steroid Biochem. Mol. Biol., 80, pp. 213-230
  • Kleinberg, D.L., Barcellos-Hoff, M.H., The pivotal role of insulin-like growth factor I in normal mammary development (2011) Endocrinol. Metab. Clin. North Am., 40, pp. 461-471
  • Lacau-Mengido, I.M., Mejía, M.E., Díaz-Torga, G.S., González-Iglesias, A., Formía, N., Libertun, C., Becú-Villalobos, D., Endocrine studies in ivermectin-treated heifers from birth to puberty (2000) J. Anim. Sci., 78, pp. 817-824
  • Luque, G.M., Perez-Millan, M.I., Ornstein, A.M., Cristina, C., Becu-Villalobos, D., Inhibitory effects of antivascular endothelial growth factor strategies in experimental dopamine-resistant prolactinomas (2011) J. Pharmacol. Exp. Ther., 337, pp. 766-774
  • McNally, S., Martin, F., Molecular regulators of pubertal mammary gland development (2011) Ann. Med., 43, pp. 212-234
  • Mejía, M.E., Fernández-Igartúa, B.M., Schmidt, E.E., Cabaret, J., Multispecies and multiple anthelmintic resistance on cattle nematodes in a farm in Argentina: The beginning of high resistance? (2003) Vet. Res., 34, pp. 461-467
  • Mejía, M., González-Iglesias, A., Díaz-Torga, G.S., Villafañe, P., Formía, N., Libertun, C., Becú-Villalobos, D., Lacau-Mengido, I.M., Effects of continuous ivermectin treatment from birth to puberty on growth and reproduction in dairy heifers (1999) J. Anim. Sci., 77, pp. 1329-1334
  • Mejía, M.E., Perri, A.F., Miglierina, M.M., Formia, N., Becu-Villalobos, D., Lacau-Mengido, I.M., Effect of anthelmintics on reproductive performance and first-lactation culling rate in Holstein heifers (2009) Vet. Rec., 165, pp. 743-746
  • Meyer, M.J., Capuco, A.V., Ross, D.A., Lintault, L.M., Van Amburgh, M.E., Developmental and nutritional regulation of the prepubertal bovine mammary gland: II. Epithelial cell proliferation, parenchymal accretion rate, and allometric growth (2006) J. Dairy Sci., 89, pp. 4298-4304. , a
  • Meyer, M.J., Capuco, A.V., Ross, D.A., Lintault, L.M., Van Amburgh, M.E., Developmental and nutritional regulation of the prepubertal heifer mammary gland: I. Parenchyma and fat pad mass and composition (2006) J. Dairy Sci., 89, pp. 4289-4297. , b
  • Meyer, M.J., Rhoads, R.P., Capuco, A.V., Connor, E.E., Hummel, A., Boisclair, Y.R., Van Amburgh, M.E., Ontogenic and nutritional regulation of steroid receptor and IGF-I transcript abundance in the prepubertal heifer mammary gland (2007) J. Endocrinol., 195, pp. 59-66
  • Mueller, S.O., Clark, J.A., Myers, P.H., Korach, K.S., Mammary gland development in adult mice requires epithelial and stromal estrogen receptor alpha (2002) Endocrinology, 143, pp. 2357-2365
  • Nødtvedt, A., Dohoo, I., Sanchez, J., Conboy, G., DesCoteaux, L., Keefe, G., Increase in milk yield following eprinomectin treatment at calving in pastured dairy cattle (2002) Vet. Parasitol., 105, pp. 191-206
  • Odiere, M.R., Scott, M.E., Weiler, H.A., Koski, K.G., Protein deficiency and nematode infection during pregnancy and lactation reduce maternal bone mineralization and neonatal linear growth in mice (2010) J. Nutr., 140, pp. 1638-1645
  • Ortega, H.H., Salvetti, N.R., Padmanabhan, V., Developmental programming: Prenatal androgen excess disrupts ovarian steroid receptor balance (2009) Reproduction, 137, pp. 865-877
  • Perri, A.F., Mejia, M.E., Licoff, N., Diab, S., Formia, N., Ornstein, A., Becu-Villalobos, D., Lacau-Mengido, I.M., Gastrointestinal parasite control during prepuberty improves mammary parenchyma development in Holstein heifers (2013) Vet. Parasitol., 198, pp. 345-350
  • Perri, A.F., Mejia, M.E., Licoff, N., Lazaro, L., Miglierina, M., Ornstein, A., Becu-Villalobos, D., Lacau-Mengido, I.M., Gastrointestinal parasites presence during the peripartum decreases total milk production in grazing dairy Holstein cows (2011) Vet. Parasitol., 178, pp. 311-318
  • Plath-Gabler, A., Gabler, C., Sinowatz, F., Berisha, B., Schams, D., The expression of the IGF family and GH receptor in the bovine mammary gland (2001) J. Endocrinol., 168, pp. 39-48
  • Reindl, K.M., Sheridan, M.A., Peripheral regulation of the growth hormone-insulin-like growth factor system in fish and other vertebrates (2012) Comp. Biochem. Physiol. A Mol. Integr. Physiol., 163, pp. 231-245
  • Sejrsen, K., Purup, S., Influence of prepubertal feeding level on milk yield potential of dairy heifers: A review (1997) J. Anim. Sci., 75, pp. 828-835
  • Sejrsen, K., Purup, S., Vestergaard, M., Foldager, J., High body weight gain and reduced bovine mammary growth: Physiological basis and implications for milk yield potential (2000) Domest. Anim. Endocrinol., 19, pp. 93-104
  • Sithole, F., Dohoo, I., Leslie, K., DesCoteaux, L., Godden, S., Campbell, J., Stryhn, H., Sanchez, J., Effect of eprinomectin treatment at calving on milk production in dairy herds with limited outdoor exposure (2005) J. Dairy Sci., 88, pp. 929-937
  • Symons, L.E., Anorexia: Occurrence, pathophysiology, and possible causes in parasitic infections (1985) Adv. Parasitol., 24, pp. 103-133
  • Tapanainen, P.J., Bang, P., Wilson, K., Unterman, T.G., Vreman, H.J., Rosenfeld, R.G., Maternal hypoxia as a model for intrauterine growth retardation: Effects on insulin-like growth factors and their binding proteins (1994) Pediatr. Res., 36, pp. 152-158
  • Tolleson, D.R., Carstens, G.E., Welsh, T.H., Teel, P.D., Strey, O.F., Longnecker, M.T., Prince, S.D., Banik, K.K., Plane of nutrition by tick-burden interaction in cattle: Effect on growth and metabolism (2012) J. Anim. Sci., 90, pp. 3442-3450
  • Tolleson, D.R., Teel, P.D., Stuth, J.W., Strey, O.F., Welsh, T.H., Carstens, G.E., Longnecker, M.T., Prince, S.D., Effects of a lone star tick (Amblyomma americanum) burden on performance and metabolic indicators in growing beef steers (2010) Vet. Parasitol., 173, pp. 99-106
  • Tucker, H.A., Quantitative estimates of mammary growth during various physiological states: A review (1987) J. Dairy Sci., 70, pp. 1958-1966
  • Weber, M.S., Purup, S., Vestergaard, M., Akers, R.M., Sejrsen, K., Regulation of local synthesis of insulin-like growth factor-I and binding proteins in mammary tissue (2000) J. Dairy Sci., 83, pp. 30-37
  • Whitlock, B.K., VandeHaar, M.J., Silva, L.F., Tucker, H.A., Effect of dietary protein on prepubertal mammary development in rapidly growing dairy heifers (2002) J. Dairy Sci., 85, pp. 1516-1525
  • Wolf, E., Jehle, P.M., Weber, M.M., Sauerwein, H., Daxenberger, A., Breier, B.H., Besenfelder, U., Brem, G., Human insulin-like growth factor I (IGF-I) produced in the mammary glands of transgenic rabbits: Yield, receptor binding, mitogenic activity, and effects on IGF-binding proteins (1997) Endocrinology, 138, pp. 307-313
  • Wolf, E., Lahm, H., Wu, M., Wanke, R., Hoeflich, A., Effects of IGFBP-2 overexpression in vitro and in vivo (2000) Pediatr. Nephrol., 14, pp. 572-578
  • Woodward, T.L., Xie, J.W., Haslam, S.Z., The role of mammary stroma in modulating the proliferative response to ovarian hormones in the normal mammary gland (1998) J. Mammary Gland Biol. Neoplasia, 3, pp. 117-131

Citas:

---------- APA ----------
Perri, A.F., Dallard, B.E., Baravalle, C., Licoff, N., Formía, N., Ortega, H.H., Becú-Villalobos, D.,..., Lacau-Mengido, I.M. (2014) . Cellular proliferation rate and insulin-like growth factor binding protein (IGFBP)-2 and IGFBP-3 and estradiol receptor alpha expression in the mammary gland of dairy heifers naturally infected with gastrointestinal nematodes during development. Journal of Dairy Science, 97(8), 4985-4996.
http://dx.doi.org/10.3168/jds.2014-8070
---------- CHICAGO ----------
Perri, A.F., Dallard, B.E., Baravalle, C., Licoff, N., Formía, N., Ortega, H.H., et al. "Cellular proliferation rate and insulin-like growth factor binding protein (IGFBP)-2 and IGFBP-3 and estradiol receptor alpha expression in the mammary gland of dairy heifers naturally infected with gastrointestinal nematodes during development" . Journal of Dairy Science 97, no. 8 (2014) : 4985-4996.
http://dx.doi.org/10.3168/jds.2014-8070
---------- MLA ----------
Perri, A.F., Dallard, B.E., Baravalle, C., Licoff, N., Formía, N., Ortega, H.H., et al. "Cellular proliferation rate and insulin-like growth factor binding protein (IGFBP)-2 and IGFBP-3 and estradiol receptor alpha expression in the mammary gland of dairy heifers naturally infected with gastrointestinal nematodes during development" . Journal of Dairy Science, vol. 97, no. 8, 2014, pp. 4985-4996.
http://dx.doi.org/10.3168/jds.2014-8070
---------- VANCOUVER ----------
Perri, A.F., Dallard, B.E., Baravalle, C., Licoff, N., Formía, N., Ortega, H.H., et al. Cellular proliferation rate and insulin-like growth factor binding protein (IGFBP)-2 and IGFBP-3 and estradiol receptor alpha expression in the mammary gland of dairy heifers naturally infected with gastrointestinal nematodes during development. J. Dairy Sci. 2014;97(8):4985-4996.
http://dx.doi.org/10.3168/jds.2014-8070