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Llinás, R.R.; Choi, S.; Urbano, F.J.; Shin, H.-S. "γ-Band deficiency and abnormal thalamocortical activity in P/Q-type channel mutant mice" (2007) Proceedings of the National Academy of Sciences of the United States of America. 104(45):17819-17824
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Abstract:

Thalamocortical in vivo and in vitro function was studied in mice lacking P/Q-type calcium channels (CaV2.1), in which N-type calcium channels (CaV2.2) supported central synaptic transmission. Unexpectedly, in vitro patch recordings from thalamic neurons demonstrated no γ-band subthreshold oscillation, and voltage-sensitive dye imaging demonstrated an absence of cortical γ-band-dependent columnar activation involving cortical inhibitory interneuron activity. In vivo electroencephalogram recordings showed persistent absence status and a dramatic reduction of γ-band activity. Pharmacological block of T-type calcium channels (CaV3), although not noticeably affecting normal control animals, left the knockout mice in a coma-like state. Hence, although N-type calcium channels can rescue P/Q-dependent synaptic transmission, P/Q calcium channels are essential in the generation of γ-band activity and resultant cognitive function. © 2007 by The National Academy of Sciences of the USA.

Registro:

Documento: Artículo
Título:γ-Band deficiency and abnormal thalamocortical activity in P/Q-type channel mutant mice
Autor:Llinás, R.R.; Choi, S.; Urbano, F.J.; Shin, H.-S.
Filiación:Department of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue, New York, NY 10016, United States
Center for Neural Science, Korea Institute of Science and Technology, Seoul 136-791, South Korea
Department of Neuroscience, University of Science and Technology, Daejon 305-333, South Korea
Laboratotio de Fisiología Y Biología Molecular, Instituto de Fisiología, Biología Molecular Y Neurociencias, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina
Palabras clave:1-Octanol; Calcium channel; Electroencephalogram; Patch clamp; VSDI; calcium channel L type; calcium channel N type; calcium channel P type; calcium channel Q type; mutant protein; animal cell; article; brain cortex; coma; controlled study; electroencephalogram; in vitro study; in vivo study; nonhuman; oscillation; priority journal; protein deficiency; synaptic transmission; thalamus nucleus; Animalia; Mus
Año:2007
Volumen:104
Número:45
Página de inicio:17819
Página de fin:17824
DOI: http://dx.doi.org/10.1073/pnas.0707945104
Título revista:Proceedings of the National Academy of Sciences of the United States of America
Título revista abreviado:Proc. Natl. Acad. Sci. U. S. A.
ISSN:00278424
CODEN:PNASA
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00278424_v104_n45_p17819_Llinas

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Citas:

---------- APA ----------
Llinás, R.R., Choi, S., Urbano, F.J. & Shin, H.-S. (2007) . γ-Band deficiency and abnormal thalamocortical activity in P/Q-type channel mutant mice. Proceedings of the National Academy of Sciences of the United States of America, 104(45), 17819-17824.
http://dx.doi.org/10.1073/pnas.0707945104
---------- CHICAGO ----------
Llinás, R.R., Choi, S., Urbano, F.J., Shin, H.-S. "γ-Band deficiency and abnormal thalamocortical activity in P/Q-type channel mutant mice" . Proceedings of the National Academy of Sciences of the United States of America 104, no. 45 (2007) : 17819-17824.
http://dx.doi.org/10.1073/pnas.0707945104
---------- MLA ----------
Llinás, R.R., Choi, S., Urbano, F.J., Shin, H.-S. "γ-Band deficiency and abnormal thalamocortical activity in P/Q-type channel mutant mice" . Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 45, 2007, pp. 17819-17824.
http://dx.doi.org/10.1073/pnas.0707945104
---------- VANCOUVER ----------
Llinás, R.R., Choi, S., Urbano, F.J., Shin, H.-S. γ-Band deficiency and abnormal thalamocortical activity in P/Q-type channel mutant mice. Proc. Natl. Acad. Sci. U. S. A. 2007;104(45):17819-17824.
http://dx.doi.org/10.1073/pnas.0707945104