Navegar

Colección

Datos Estadísticas

Artículo

Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

During development of the rat anterior pituitary gland (APG) there is a fall in DNA replication which is accompanied by a decline in the activity of the soluble DNA polymerase and of an endonuclease. This latter enzyme is capable of activating the DNA template for the DNA polymerase assay. Sulpiride sulfate, a drug known to produce prolactin release from the APG, increases thymidine incorporation in the APG 20 h after the injection. This drug also enhances the activity of the soluble DNA polymerase while that of the endonuclease and thymidine kinase does not change. The results suggest that the intracellular prolactin content regulates DNA replication in mammotrophs and that the soluble DNA polymerase plays an important role in this regulation. © 1979 S. Karger AG, Basel.

Registro:

Documento: Artículo
Título:DNA synthesis in the pituitary gland of the rat: Effect of sulpiride and postnatal maturation
Autor:Kalbermann, L.E.; Szijan, I.; Jahn, G.A.; Krawiec, L.; Burdman, J.A.
Filiación:Departamento de Química Biológica, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:DNA synthesis; Pituitary gland; Prolactin; Sulpiride; dna polymerase; endonuclease; prolactin; sulpiride; thymidine kinase; adenohypophysis; animal experiment; dna synthesis; endocrine system; hypophysis; rat; Aging; Animals; Deoxyribonucleases; DNA; DNA Replication; DNA-Directed DNA Polymerase; Endonucleases; Pituitary Gland, Anterior; Rats; Sulpiride; Thymidine Kinase
Año:1979
Volumen:29
Número:1
Página de inicio:42
Página de fin:48
DOI: http://dx.doi.org/10.1159/000122903
Título revista:Neuroendocrinology
Título revista abreviado:Neuroendocrinology
ISSN:00283835
CAS:DNA polymerase, 37217-33-7; endonuclease, 9055-11-2; prolactin, 12585-34-1, 50647-00-2, 9002-62-4; sulpiride, 15676-16-1; thymidine kinase, 9002-06-6, 9086-73-1; DNA, 9007-49-2; DNA-Directed DNA Polymerase, 2.7.7.7; Deoxyribonucleases, 3.1.-; Endonucleases, 3.1.-; Sulpiride, 15676-16-1; Thymidine Kinase, 2.7.1.21
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00283835_v29_n1_p42_Kalbermann

Referencias:

  • Barka, T., Stimulation of DNA synthesis by iso-proterenol in the salivary gland (1965) Exp. Cell Ress, 39, pp. 355-364
  • Baserga, R., Rovera, G., Farber, J., Control of cellular proliferation in human diploid fibroblasts (1971) Vitro, 7, pp. 80-87
  • Burdman, J.A., Jahn, G.A., Szijan, I., Early events in the effect of hydrocortisone acetate on DNA replication in the rat brain (1975) J. Neurochem, 24, pp. 663-666
  • Burdman, J.A., Szijan, I., Effect of acidic deoxyribonucleoproteins from brain on DNA synthesis in vitro (1976) J. Neurochem, 26, pp. 1245-1261
  • Burton, K., A study of the conditions and mechanism of the diphenylamine reaction for the colori-metric estimation of deoxyribonucleic acid (1956) Biochem. J, 62, pp. 315-323
  • Chiu, J.F., Sung, S.C., Separation and characterization of protein factor of DNA polymerase B from developing rat brain (1973) Biochim. Biophys. Acta, 33J, pp. 54-60
  • Crane, W.A., Loomes, R.S., Effect of age, sex and hormonal state on tritiated thymidine uptake by rat pituitary (1967) Br. J. Cancer, 21, pp. 787-792
  • Davies, C., Jacobi, J., Lloyd, H.M., Meares, J.D., DNA synthesis and the secretion of prolactin and growth hormone by the pituitary gland of the male rat. Effects of diethylstilboestrol and 2-bromo-ergo-cryptine methane sulphonate (1974) J. Endocr, 61, pp. 411-417
  • Debeljuk, L., Rozados, R., Daskal, H., Villegas Velez, C., Mancini, A.H., Acute and chronic effects of sulpiride on serum prolactin and gonadotropin levels in castrated male rats (1975) Proc. Soc. Exp. Biol. Med, 148, pp. 550-552
  • Hymer, W.C., Mastro, A., Griswold, E., DNA synthesis in the anterior pituitary of the male rat. Effect of castration and photoperiod (1970) Science, 167, pp. 1629-1630
  • Mastro, A., Hymer, W.C., The effect of age and oestrone treatment on DNA polymerase activity in anterior pituitary glands of male rats (1973) J. Endocr, 59, pp. 107-119
  • Sazaki, T., Litwack, G., Baserga, R., Protein synthesis in the early prereplicative phase of iso-proterenol-stimulated synthesisof deoxyribonucleic acid (1969) J. Biol. Chem, 244, pp. 4831-4837
  • Stevens, E., Helfenstein, J.E., Some effects of certain naturally occurring oestrogcns on the anterior pituitary glands of rats (1966) Nature, 211, pp. 879-880. , Lond
  • Studzinski, G.P., Fischman, G.J., Activation of DNA primer for DNA polymerase as an ultrasensitive assay for a subgroup of enzymes with deoxyribonuclease activity (1974) Analyt. Biochem, 58, pp. 449-458
  • Szijan, I., Burdman, J.A., DNA polymerase activity in fractions from brain cell nuclei (1974) Brain Res, 73, pp. 563-567
  • Valotaire, Y., Duval, J., Regulation of rat pituitary thymidine kinase activity by androgens (1973) Acta Endocr, 73, pp. 612-624. , Copenh

Citas:

---------- APA ----------
Kalbermann, L.E., Szijan, I., Jahn, G.A., Krawiec, L. & Burdman, J.A. (1979) . DNA synthesis in the pituitary gland of the rat: Effect of sulpiride and postnatal maturation. Neuroendocrinology, 29(1), 42-48.
http://dx.doi.org/10.1159/000122903
---------- CHICAGO ----------
Kalbermann, L.E., Szijan, I., Jahn, G.A., Krawiec, L., Burdman, J.A. "DNA synthesis in the pituitary gland of the rat: Effect of sulpiride and postnatal maturation" . Neuroendocrinology 29, no. 1 (1979) : 42-48.
http://dx.doi.org/10.1159/000122903
---------- MLA ----------
Kalbermann, L.E., Szijan, I., Jahn, G.A., Krawiec, L., Burdman, J.A. "DNA synthesis in the pituitary gland of the rat: Effect of sulpiride and postnatal maturation" . Neuroendocrinology, vol. 29, no. 1, 1979, pp. 42-48.
http://dx.doi.org/10.1159/000122903
---------- VANCOUVER ----------
Kalbermann, L.E., Szijan, I., Jahn, G.A., Krawiec, L., Burdman, J.A. DNA synthesis in the pituitary gland of the rat: Effect of sulpiride and postnatal maturation. Neuroendocrinology. 1979;29(1):42-48.
http://dx.doi.org/10.1159/000122903