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Abstract:

Anatomical and functional brain studies have converged to the hypothesis that autism spectrum disorders (ASD) are associated with atypical connectivity. Using a modified resting-state paradigm to drive subjects' attention, we provide evidence of a very marked interaction between ASD brain functional connectivity and cognitive state. We show that functional connectivity changes in opposite ways in ASD and typicals as attention shifts from external world towards one's body generated information. Furthermore, ASD subject alter more markedly than typicals their connectivity across cognitive states. Using differences in brain connectivity across conditions, we ranked brain regions according to their classification power. Anterior insula and dorsal-anterior cingulate cortex were the regions that better characterize ASD differences with typical subjects across conditions, and this effect was modulated by ASD severity. These results pave the path for diagnosis of mental pathologies based on functional brain networks obtained from a library of mental states. © 2012 Elsevier Ltd.

Registro:

Documento: Artículo
Título:State-dependent changes of connectivity patterns and functional brain network topology in autism spectrum disorder
Autor:Barttfeld, P.; Wicker, B.; Cukier, S.; Navarta, S.; Lew, S.; Leiguarda, R.; Sigman, M.
Filiación:Laboratory of Integrative Neuroscience, Physics Department, FCEyN UBA and IFIBA, Conicet, Pabellón 1, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Institut de Neurosciences de la Timone, CNRS UMR 7289, Aix-Marseille University, Marseille, France
Instituto de Ingeniería Biomédica, Facultad de Ingeniería, Universidad de Buenos Aires, 1063 Buenos Aires, Argentina
FLENI, 1428 Buenos Aires, Argentina
Palabras clave:ADOS score; Autism spectrum disorders; Brain states; Functional connectivity; adult; angular gyrus; anterior cingulate; anterior insula; article; attention; autism; basal ganglion; brain region; clinical article; cognition; controlled study; disease association; disease severity; DSM-IV; female; functional magnetic resonance imaging; human; inferior parietal lobule; inferior temporal cortex; male; precuneus; prefrontal cortex; state dependent learning; Adolescent; Attention Deficit Disorder with Hyperactivity; Brain; Brain Mapping; Child; Child Development Disorders, Pervasive; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Neural Pathways; Oxygen; Rest; Young Adult
Año:2012
Volumen:50
Número:14
Página de inicio:3653
Página de fin:3662
DOI: http://dx.doi.org/10.1016/j.neuropsychologia.2012.09.047
Título revista:Neuropsychologia
Título revista abreviado:Neuropsychologia
ISSN:00283932
CODEN:NUPSA
CAS:Oxygen, 7782-44-7
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00283932_v50_n14_p3653_Barttfeld

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Citas:

---------- APA ----------
Barttfeld, P., Wicker, B., Cukier, S., Navarta, S., Lew, S., Leiguarda, R. & Sigman, M. (2012) . State-dependent changes of connectivity patterns and functional brain network topology in autism spectrum disorder. Neuropsychologia, 50(14), 3653-3662.
http://dx.doi.org/10.1016/j.neuropsychologia.2012.09.047
---------- CHICAGO ----------
Barttfeld, P., Wicker, B., Cukier, S., Navarta, S., Lew, S., Leiguarda, R., et al. "State-dependent changes of connectivity patterns and functional brain network topology in autism spectrum disorder" . Neuropsychologia 50, no. 14 (2012) : 3653-3662.
http://dx.doi.org/10.1016/j.neuropsychologia.2012.09.047
---------- MLA ----------
Barttfeld, P., Wicker, B., Cukier, S., Navarta, S., Lew, S., Leiguarda, R., et al. "State-dependent changes of connectivity patterns and functional brain network topology in autism spectrum disorder" . Neuropsychologia, vol. 50, no. 14, 2012, pp. 3653-3662.
http://dx.doi.org/10.1016/j.neuropsychologia.2012.09.047
---------- VANCOUVER ----------
Barttfeld, P., Wicker, B., Cukier, S., Navarta, S., Lew, S., Leiguarda, R., et al. State-dependent changes of connectivity patterns and functional brain network topology in autism spectrum disorder. Neuropsychologia. 2012;50(14):3653-3662.
http://dx.doi.org/10.1016/j.neuropsychologia.2012.09.047