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Abstract:

In this paper we report the synthesis of four fluorinated analogues of brassinosteroids in which fluorine was introduced stereoselectively at C-2. The bioactivity of these new compounds was evaluated using the rice lamina inclination test. The results show that two of these analogues elicit high bioactivity, suggesting the involvement of hydrogen bond interactions between the active brassinosteroids and their cellular receptor. © 2008 Elsevier Inc. All rights reserved.

Registro:

Documento: Artículo
Título:Synthesis and biological activity of brassinosteroids fluorinated at C-2
Autor:Acebedo, S.L.; Ramírez, J.A.; Galagovsky, L.R.
Filiación:Departamento de Quimica Organica and UMYMFOR (CONICET - Facultad de Ciencias Exactas y Naturales), Universidad de Buenos Aires, Pabellon 2, Piso 3, Ciudad Universitaria, C1428EGA Buenos Aires, Argentina
Palabras clave:Brassinosteroids; Fluorinated steroids; Oryza sativa; 2alpha fluoro 3alpha,22,23 trihydroxy 5alpha stigmastan 6 one; 2alpha fluoro 3beta,22,23 trihydroxy 5alpha stigmastan 6 one; brassinosteroid; carbon; cell receptor; fluorinated steroid; hydrogen; unclassified drug; analytic method; article; biological activity; chemical bond; chemical interaction; chemical structure; fluorination; germination; hydrogen bond; nonhuman; plant growth; rice; seedling; stereochemistry; synthesis; Biological Assay; Cholestanols; Halogenation; Oryza sativa; Steroids, Heterocyclic; Oryza sativa
Año:2009
Volumen:74
Número:4-5
Página de inicio:435
Página de fin:440
DOI: http://dx.doi.org/10.1016/j.steroids.2008.12.006
Título revista:Steroids
Título revista abreviado:Steroids
ISSN:0039128X
CODEN:STEDA
CAS:carbon, 7440-44-0; hydrogen, 12385-13-6, 1333-74-0; Cholestanols; Steroids, Heterocyclic; brassinolide, 72962-43-7
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0039128X_v74_n4-5_p435_Acebedo

Referencias:

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Citas:

---------- APA ----------
Acebedo, S.L., Ramírez, J.A. & Galagovsky, L.R. (2009) . Synthesis and biological activity of brassinosteroids fluorinated at C-2. Steroids, 74(4-5), 435-440.
http://dx.doi.org/10.1016/j.steroids.2008.12.006
---------- CHICAGO ----------
Acebedo, S.L., Ramírez, J.A., Galagovsky, L.R. "Synthesis and biological activity of brassinosteroids fluorinated at C-2" . Steroids 74, no. 4-5 (2009) : 435-440.
http://dx.doi.org/10.1016/j.steroids.2008.12.006
---------- MLA ----------
Acebedo, S.L., Ramírez, J.A., Galagovsky, L.R. "Synthesis and biological activity of brassinosteroids fluorinated at C-2" . Steroids, vol. 74, no. 4-5, 2009, pp. 435-440.
http://dx.doi.org/10.1016/j.steroids.2008.12.006
---------- VANCOUVER ----------
Acebedo, S.L., Ramírez, J.A., Galagovsky, L.R. Synthesis and biological activity of brassinosteroids fluorinated at C-2. Steroids. 2009;74(4-5):435-440.
http://dx.doi.org/10.1016/j.steroids.2008.12.006