Artículo
Veleiro, A.S.; Taich, P.J.; Alvarez, L.D.; Di Chenna, P.H.; Burton, G. "Synthesis of C(1)-C(11) oxygen-bridged pregnanes" (2005) Tetrahedron Letters. 46(24):4235-4238
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Abstract:
A general procedure for the synthesis of 1α,11α- and 1β,11α-epoxysteroids is described, using an intramolecular remote functionalization reaction involving the photolysis of 11α-hydroxysteroids in the presence of diacetoxyiodobenzene and iodine. Three 1,11-epoxypregnanes were prepared, two of them (compounds 10 and 14) are conformationally constrained analogues of steroidal hormones, compound 13 is a synthetic precursor of neurosteroids. © 2005 Elsevier Ltd. All rights reserved.
Registro:
| Documento: | Artículo |
| Título: | Synthesis of C(1)-C(11) oxygen-bridged pregnanes |
| Autor: | Veleiro, A.S.; Taich, P.J.; Alvarez, L.D.; Di Chenna, P.H.; Burton, G. |
| Filiación: | Departamento de Química Orgánica and UMYMFOR (CONICET-FCEN), Facultad de Ciencias Exactas Y Naturales, Ciudad Universitaria, C1428EGA Buenos Aires, Argentina |
| Palabras clave: | 1,11-Epoxypregnane; Diacetoxyiodobenzene; DIB; Remote functionalization reaction; Steroid; hydroxysteroid; iodine; iodobenzene; pregnane derivative; steroid hormone; article; chemical reaction kinetics; drug conformation; drug synthesis; photolysis |
| Año: | 2005 |
| Volumen: | 46 |
| Número: | 24 |
| Página de inicio: | 4235 |
| Página de fin: | 4238 |
| DOI: | http://dx.doi.org/10.1016/j.tetlet.2005.04.052 |
| Título revista: | Tetrahedron Letters |
| Título revista abreviado: | Tetrahedron Lett. |
| ISSN: | 00404039 |
| CODEN: | TELEA |
| CAS: | iodine, 7553-56-2; iodobenzene, 591-50-4 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00404039_v46_n24_p4235_Veleiro |
Referencias:
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- note; note; note; note; note
Citas:
---------- APA ----------
Veleiro, A.S., Taich, P.J., Alvarez, L.D., Di Chenna, P.H. & Burton, G. (2005) . Synthesis of C(1)-C(11) oxygen-bridged pregnanes. Tetrahedron Letters, 46(24), 4235-4238.http://dx.doi.org/10.1016/j.tetlet.2005.04.052
---------- CHICAGO ----------
Veleiro, A.S., Taich, P.J., Alvarez, L.D., Di Chenna, P.H., Burton, G. "Synthesis of C(1)-C(11) oxygen-bridged pregnanes" . Tetrahedron Letters 46, no. 24 (2005) : 4235-4238.http://dx.doi.org/10.1016/j.tetlet.2005.04.052
---------- MLA ----------
Veleiro, A.S., Taich, P.J., Alvarez, L.D., Di Chenna, P.H., Burton, G. "Synthesis of C(1)-C(11) oxygen-bridged pregnanes" . Tetrahedron Letters, vol. 46, no. 24, 2005, pp. 4235-4238.http://dx.doi.org/10.1016/j.tetlet.2005.04.052
---------- VANCOUVER ----------
Veleiro, A.S., Taich, P.J., Alvarez, L.D., Di Chenna, P.H., Burton, G. Synthesis of C(1)-C(11) oxygen-bridged pregnanes. Tetrahedron Lett. 2005;46(24):4235-4238.http://dx.doi.org/10.1016/j.tetlet.2005.04.052
