Artículo

Toscano, M.A.; Tongren, J.E.; De Souza, J.B.; Liu, F.-T.; Riley, E.M.; Rabinovich, G.A. "Endogenous galectin-3 controls experimental malaria in a species-specific manner" (2012) Parasite Immunology. 34(7):383-387
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Abstract:

Galectins are evolutionarily conserved glycan-binding proteins with pleiotropic roles in innate and adaptive immune responses. Galectin-3 has been implicated in several immunological processes as well as in pathogen recognition through specific binding to glycosylated receptors on the surface of host cells or microorganisms. In spite of considerable evidence supporting a role for galectin-3 in host-pathogen interactions, the relevance of this lectin in the regulation of the host defence mechanisms in vivo is poorly understood. In this study, we analysed the impact of galectin-3 deficiency during infection with three distinct species of rodent malaria parasites, Plasmodium yoelii 17XNL, Plasmodium berghei ANKA and Plasmodium chabaudi AS. We found that galectin-3 deficiency showed a marginal effect on the course of parasitaemia during P. chabaudi infection, but did not alter the course of parasitaemia during P. berghei infection. However, lack of galectin-3 significantly reduced P. yoelii parasitaemia. This reduced parasitaemia in Lgals3 -/- mice was consistent with higher titres of anti-P. yoelii MSP1 19 IgG2b isotype antibodies when compared with their wild-type counterparts. Our results reflect the complexity and singularity of host-pathogen interactions, indicating a species-specific role of endogenous galectin-3 in the control of parasite infections and the modulation of antibody responses. © 2012 Blackwell Publishing Ltd.

Registro:

Documento: Artículo
Título:Endogenous galectin-3 controls experimental malaria in a species-specific manner
Autor:Toscano, M.A.; Tongren, J.E.; De Souza, J.B.; Liu, F.-T.; Riley, E.M.; Rabinovich, G.A.
Filiación:Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina
Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
Division of Infection and Immunity, University College London Medical School, Cruciform Building, London, United Kingdom
Department of Dermatology, School of Medicine, University of California Davis, Sacramento, CS, United States
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
President's Malaria Initiative (PMI), Centers for Disease Control and Prevention, Kigali, Rwanda
Palabras clave:Galectin-3; Immunoglobulin G; Plasmodium spp.; galectin 3; immunoglobulin G2b; protozoon antibody; animal cell; animal experiment; animal model; antibody response; antibody titer; article; controlled study; erythrocyte; hematocrit; host pathogen interaction; immunoglobulin blood level; lymphocyte; monocyte; mouse; nonhuman; parasitemia; Plasmodium berghei; Plasmodium berghei infection; Plasmodium chabaudi; Plasmodium chabaudi infection; Plasmodium yoelii; Plasmodium yoelii infection; polymorphonuclear cell; priority journal; protein deficiency; reticulocyte; species difference; wild type; Animals; Antibodies, Protozoan; Disease Models, Animal; Female; Galectin 3; Host-Pathogen Interactions; Immunoglobulin G; Malaria; Mice; Mice, Knockout; Parasitemia; Plasmodium berghei; Plasmodium chabaudi; Plasmodium yoelii
Año:2012
Volumen:34
Número:7
Página de inicio:383
Página de fin:387
DOI: http://dx.doi.org/10.1111/j.1365-3024.2012.01366.x
Título revista:Parasite Immunology
Título revista abreviado:Parasite Immunol.
ISSN:01419838
CODEN:PAIMD
CAS:galectin 3, 208128-56-7; Antibodies, Protozoan; Galectin 3; Immunoglobulin G; Lgals3 protein, mouse
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01419838_v34_n7_p383_Toscano

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Citas:

---------- APA ----------
Toscano, M.A., Tongren, J.E., De Souza, J.B., Liu, F.-T., Riley, E.M. & Rabinovich, G.A. (2012) . Endogenous galectin-3 controls experimental malaria in a species-specific manner. Parasite Immunology, 34(7), 383-387.
http://dx.doi.org/10.1111/j.1365-3024.2012.01366.x
---------- CHICAGO ----------
Toscano, M.A., Tongren, J.E., De Souza, J.B., Liu, F.-T., Riley, E.M., Rabinovich, G.A. "Endogenous galectin-3 controls experimental malaria in a species-specific manner" . Parasite Immunology 34, no. 7 (2012) : 383-387.
http://dx.doi.org/10.1111/j.1365-3024.2012.01366.x
---------- MLA ----------
Toscano, M.A., Tongren, J.E., De Souza, J.B., Liu, F.-T., Riley, E.M., Rabinovich, G.A. "Endogenous galectin-3 controls experimental malaria in a species-specific manner" . Parasite Immunology, vol. 34, no. 7, 2012, pp. 383-387.
http://dx.doi.org/10.1111/j.1365-3024.2012.01366.x
---------- VANCOUVER ----------
Toscano, M.A., Tongren, J.E., De Souza, J.B., Liu, F.-T., Riley, E.M., Rabinovich, G.A. Endogenous galectin-3 controls experimental malaria in a species-specific manner. Parasite Immunol. 2012;34(7):383-387.
http://dx.doi.org/10.1111/j.1365-3024.2012.01366.x