Artículo

Suárez, C.; Díaz-Torga, G.; Gonzalez-Iglesias, A.; Vela, J.; Mladovan, A.; Baldi, A.; Becu-Villalobos, D. "Angiotensin II phosphorylation of extracellular signal-regulated kinases in rat anterior pituitary cells" (2003) American Journal of Physiology - Endocrinology and Metabolism. 285(3 48-3):E645-E653
Estamos trabajando para incorporar este artículo al repositorio
Consulte la política de Acceso Abierto del editor

Abstract:

We studied the effects of ANG II on extracellular signal-regulated kinase (ERK)1/2 phosphorylation in rat pituitary cells. ANG II increased ERK phosphorylation in a time- and concentration-dependent way. Maximum effect was obtained at 5 min at a concentration of 10-100 nM. The effect of 100 nM ANG II was blocked by the AT1 antagonist DUP-753, by the phospholipase C (PLC) inhibitor U-73122, and by the MAPK kinase (MEK) antagonist PD-98059. The ANG II-induced increase in phosphorylated (p)ERK was insensitive to pertussis toxin blockade and PKC depletion or inhibition. The effect was also abrogated by chelating intracellular calcium with BAPTA-AM or TMB-8 by depleting intracellular calcium stores with a 30-min pretreatment with EGTA and by pretreatment with herbimycin A and PP1, two c-Src tyrosine kinase inhibitors. It was attenuated by AG-1478, an inhibitor of epidermal growth factor receptor (EGFR) activation. Therefore, in the rat pituitary, the increase of pERK is a Gq- and PLC-dependent process, which involves an increase in intracellular calcium and activation of a c-Src tyrosine kinase, transactivation of the EGFR, and the activation of MEK. Finally, the response of ERK activation by ANG II is altered in hyperplastic pituitary cells, in which calcium mobilization evoked by ANG II is also modified.

Registro:

Documento: Artículo
Título:Angiotensin II phosphorylation of extracellular signal-regulated kinases in rat anterior pituitary cells
Autor:Suárez, C.; Díaz-Torga, G.; Gonzalez-Iglesias, A.; Vela, J.; Mladovan, A.; Baldi, A.; Becu-Villalobos, D.
Filiación:Inst. de Biol. Med. Exp.-CONICET, 1428 Buenos Aires, Argentina
Inst. de Biol. Med. Exp.-CONICET, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:Calcium; Epidermal growth factor receptor; Estrogen; Mitogen-activated protein kinase; Phospholipase C; Protein kinase C; 1 [[6 (3 methoxyestra 1,3,5(10) trien 17beta yl)amino]hexyl] 1h pyrrole 2,5 dione; 2 (2 amino 3 methoxyphenyl)chromone; 3,4,5 trimethoxybenzoic acid 8 (diethylamino)octyl ester; 4 (3 chloroanilino) 6,7 dimethoxyquinazoline; angiotensin; egtazic acid; epidermal growth factor receptor; ethylene glycol 1,2 bis(2 aminophenyl) ether n,n,n',n' tetraacetic acid; herbimycin; losartan potassium; mitogen activated protein kinase; mitogen activated protein kinase 1; pertussis toxin; protein tyrosine kinase inhibitor; adenohypophysis; animal cell; animal experiment; article; calcium cell level; calcium mobilization; cell hyperplasia; concentration response; controlled study; enzyme activation; enzyme activity; enzyme inhibition; enzyme phosphorylation; female; hypophysis cell; nonhuman; phosphorylation; priority journal; rat; Angiotensin II; Animals; Calcium; Cells, Cultured; Estrogens; Female; Hyperplasia; Mitogen-Activated Protein Kinases; Phospholipase C; Phosphorylation; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Epidermal Growth Factor; Receptors, Angiotensin; src-Family Kinases; Vasoconstrictor Agents
Año:2003
Volumen:285
Número:3 48-3
Página de inicio:E645
Página de fin:E653
Título revista:American Journal of Physiology - Endocrinology and Metabolism
Título revista abreviado:Am. J. Physiol. Endocrinol. Metab.
ISSN:01931849
CODEN:AJPMD
CAS:1 [[6 (3 methoxyestra 1,3,5(10) trien 17beta yl)amino]hexyl] 1h pyrrole 2,5 dione, 112648-68-7; 2 (2 amino 3 methoxyphenyl)chromone, 167869-21-8; 3,4,5 trimethoxybenzoic acid 8 (diethylamino)octyl ester, 57818-92-5; 4 (3 chloroanilino) 6,7 dimethoxyquinazoline, 153436-53-4; angiotensin, 1407-47-2; egtazic acid, 67-42-5; ethylene glycol 1,2 bis(2 aminophenyl) ether n,n,n',n' tetraacetic acid, 73630-08-7; herbimycin, 77699-47-9; losartan potassium, 124750-99-8; mitogen activated protein kinase 1, 137632-08-7; mitogen activated protein kinase, 142243-02-5; pertussis toxin, 70323-44-3; Angiotensin II, 11128-99-7; Calcium, 7440-70-2; Estrogens; Mitogen-Activated Protein Kinases, EC 2.7.1.37; Phospholipase C, EC 3.1.4.3; Protein Kinase C, EC 2.7.1.37; Receptor, Angiotensin, Type 1; Receptor, Epidermal Growth Factor, EC 2.7.1.112; Receptors, Angiotensin; src-Family Kinases, EC 2.7.1.112; Vasoconstrictor Agents
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01931849_v285_n348-3_pE645_Suarez

Referencias:

  • Arai, H., Escobedo, J.A., Angiotensin II type 1 receptor signals through raf-1 by a protein kinase C-dependent, ras-independent mechanism (1996) Mol Pharmacol, 50, pp. 522-528
  • Chao, T.S., Byron, K.L., Lee, K.M., Villereal, M., Rosner, M.R., Activation of MAP kinases by calcium-dependent and calcium-independent pathways. Stimulation by thapsigargin and epidermal growth factor (1992) J Biol Chem, 267, pp. 19876-19883
  • Chen, F.M., Printz, M.P., Chronic estrogen treatment reduces angiotensin II receptors in the anterior pituitary (1983) Endocrinology, 113, pp. 1503-1510
  • De Moel, M.P., Van de Put, F.H., Vermegen, T.M., De Pont, J.H., Willems, P.H., Effect of the aminosteroid, U73122, on Ca2+ uptake and release properties of rat liver microsomes (1995) Eur J Biochem, 234, pp. 626-631
  • Deschepper, C.F., The renin-angiotensin system in the pituitary gland (1991) Trends Endocrinol Metab, 2, pp. 104-107
  • Deschepper, C.F., Seidler, C.D., Steele, M.K., Ganong, W.F., Further studies on the localization of angiotensin II-like immunoreactivity in the anterior pituitary gland of the male rat, comparing various antisera to pituitary hormones and their specificity (1985) Neuroendocrinology, 40, pp. 471-475
  • Diaz-Torga, G.S., Gonzalez Iglesias, A., Achaval-Zaia, R., Libertun, C., Becu-Villalobos, D., Angiotensin II-induced Ca2+ mobilization and prolactin release in normal and hyperplastic pituitary Cells (1998) Am J Physiol Endocrinol Metab, 274, pp. E534-E540
  • Eguchi, S., Iwasaki, H., Inagami, T., Numaguchi, K., Yamakawa, T., Motley, E.D., Owada, K.M., Hirata, Y., Involvement of PYK2 in angiotensin II signaling of vascular smooth muscle cells (1999) Hypertension, 33, pp. 201-206
  • Eguchi, S., Matsumoto, T., Motley, E.D., Utsunomiya, H., Inagami, T., Identification of an essential signaling cascade for mitogen-activated protein kinase activation by angiotensin II in cultured rat vascular smooth muscle cells (1996) J Biol Chem, 271, pp. 14169-14175
  • Eguchi, S., Numaguchi, K., Iwasaki, H., Matsumoto, T., Yamakawa, T., Utsunomiya, H., Motley, E.D., Inagami, T., Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells (1998) J Biol Chem, 273, pp. 8890-8896
  • Enjalbert, A., Sladeczek, F., Guillon, G., Bertrand, P., Shu, C., Epelbaum, J., Garcia-Sainz, A., Bockaert J. II, Angiotensin dopamine modulate both cyclic AMP and inositol phosphate productions in anterior pituitary cells (1986) J Biol Chem, 261, pp. 4071-4075
  • Gonzalez Iglesias, A., Diaz-Torga, G., Lux-Lantos, V., Libertun, C., Becu-Villalobos, D., Calcium influx and intracellular stores in angiotensin II stimulation of normal and hyperplastic pituitary cels (1999) Am J Physiol Endocrinol Metab, 277, pp. E455-E463
  • Gonzalez Iglesias, A., Diaz-Torga, G., Piroli, G., Achaval-Zaia, R., De Nicola, A.F., Libertun, C., Becu-Villalobos, D., Bromocriptine restores angiotensin II response in pituitary hyperplasia (2000) Mol Cell Endocrinol, 165, pp. 67-74
  • Gonzalez Iglesias, A., Suarez, C., Feierstein, C., Diaz-Torga, G., Becu-Villalobos, D., Desensitization of angiotensin II: Effect on [Ca2+] i, inositol triphosphate, and prolactin in pituitary cells (2001) Am J Physiol Endocrinol Metab, 280, pp. E462-E470
  • Herbert, J.M., Augereau, J.M., Gleye, J., Maffran, X., Chelerythrine is a potent and specific inhibitor of protein kinase C (1990) Biochem Biophys Res Commun, 172, pp. 993-999
  • Huang, X.C., Richards, E.M., Sumners, C., Mitogen-activated protein kinases in rat brain neuronal cultures are activated by angiotensin II type 1 receptors and inhibited by angiotensin II type 2 receptors (1996) J Biol Chem, 271, pp. 15635-15641
  • Ishida, M., Ishida, T., Thomas, S., Berk, B.C., Activation of extracellular signal-regulated kinases (ERK1/2) by angiotensin II is dependent on c-Src in vascular smooth muscle cells (1998) Circ Res, 82, pp. 7-12
  • Kakar, S.S., Sellers, J.C., Devor, D.C., Musgrove, L.C., Neill, J.D., Angiotensin II type-1 receptor subtype cDNAs: Differential tissue expression and hormonal regulation (1992) Biochem Biophys Res Commun, 183, pp. 1090-1096
  • Kunert-Radek, J., Pawlikowski, M., Angiotensin II stimulation of the rat pituitary tumoral cell proliferation in vitro (1992) Biochem Biophys Res Commun, 183, pp. 27-30
  • Leduc, I., Haddad, P., Giasson, E., Meloche, S., Involvement of a tyrosine kinase pathway in the growth-promoting effects of angiotensin II on aortic smooth muscle cells (1995) Mol Pharmacol, 48, pp. 582-592
  • Lenkei, Z., Nuyt, A.M., Grouselle, D., Corvol, P., Llorens-Cortes, C., Identification of endocrine cell population expressing the AT 1B subtype of angiotensin II receptors in anterior pituitary (1999) Endocrinology, 140, pp. 472-477
  • Luttrell, L.M., Daaka, Y., Lefkowitz, R.J., Regulation of tyrosine kinase cascades by G-protein-coupled receptors (1999) Curr Opin Cell Biol, 11, pp. 177-183
  • McCormick, F., Signal transduction. How receptors turn Ras on (1993) Nature, 363, pp. 15-16
  • Mogami, H., Lloyd Mills, C., Gallacher, D.V., Phospholipase C inhibitor, U73122, releases intracellular Ca2+, potentiates Ins(1,4,5)P3-mediated Ca2+ release and directly activates ion channels in mouse pancreatic acinar cells (1997) Biochem J, 324, pp. 645-651
  • Molloy, C.J., Taylor, D.S., Weber, H., Angiotensin II stimulation of rapid protein tyrosine phosphorylation and protein kinase activation in rat aortic smooth muscle cells (1993) J Biol Chem, 268, pp. 7338-7345
  • Murasawa, S., Mori, Y., Nozawa, Y., Gotoh, N., Shibuya, M., Masaki, H., Maruyama, K., Matsubara, H., Angiotensin II type 1 receptor-induced extracellular signal-regulated protein kinase activation is mediated by Ca2+/calmodulin-dependent transactivation of epidermal growth factor (1998) Circ Res, 82, pp. 1338-1348
  • Murasawa, S., Mori, Y., Nozawa, Y., Masaki, H., Maruyama, K., Tsutsumi, Y., Shibasaki, Y., Matsubara, H., Role of calcium-sensitive tyrosine kinase Pyk2/CAKβ/RAFTK in angiotensin II-induced Ras/ERK signaling (1998) Hypertension, 32, pp. 668-675
  • Naftilan, A.J., Pratt, R.E., Eldrige, C.S., Lin, H.L., Dzau, V.J., Angiotensin II induces c-fos expression in smooth muscle cells via transcriptional control (1989) Hypertension, 13, pp. 706-711
  • Ohnishi, J., Ishido, M., Shibata, T., Inagami, T., Murakami, K., Miyazaki, H., The rat angiotensin II AT 1A receptor couples with three different signal transduction pathways (1992) Biochem Biophys Res Commun, 186, pp. 1094-1101
  • Pawlikowski, M., Grochal, M., Kulig, A., Zielinski, K., Stepien, H., Kunert-Radek, J., Mucha, S., The effect of angiotensin II receptor antagonists on diethylstilbestrol-induced vascular changes in the rat anterior pituitary gland: A quantitative evaluation (1996) Histol Histopathol, 11, pp. 909-913
  • Sadoshima, J., Qiu, Z., Morgan, J.P., Izumo S. II, Angiotensin other hypertrophic stimuli mediated by G protein-coupled receptors activate tyrosine kinase, mitogen-activated protein kinase, and 90-kD S6 kinase in cardiac mycocytes. The critical role of Ca2+-dependent signaling (1995) Circ Res, 76, pp. 1-15
  • Saito, Y., Bradford, B.C., Transactivation: A novel signaling pathway from angiotensin II to tyrosine kinase receptors (2001) J Mol Cell Cardiol, 33, pp. 3-7
  • Sanvitto, G.L., Johren, O., Hauser, W., Saavedra, J.M., Water deprivation upregulates ANG II AT 1 binding and mRNA in rat subfornical organ and anterior pituitary (1997) Am J Physiol Endocrinol Metab, 273, pp. E156-E163
  • Seltzer, A., Pinto, J.E.B., Viglione, P.N., Correa, F.M.A., Libertun, C., Tsutsumi, K., Steele, M.K., Saavedra, J.M., Estrogens regulate angiotensin-converting enzyme and angiotensin receptors in female rat anterior pituitary (1992) Neuroendocrinology, 55, pp. 460-467
  • Shah, B.H., Catt, K.J., Calcium-independent activation of extracellularly regulated kinases 1 and 2 by angiotensin II in hepatic C9 cells: Roles of protein kinase Cδ, Src/proline-rich tyrosine kinase 2, and epidermal growth factor receptor transactivation (2002) Mol Pharmacol, 61, pp. 343-351
  • Shelat, S.G., King, J.L., Flanagan-Cato, L.M., Fluharty, S.J., Mineralocorticoids and glucocorticoids cooperatively increase salt intake and angiotensin II receptor binding in rat brain (1999) Neuroendocrinology, 69, pp. 339-351
  • Suarez, C., Garcia Tornadú, I., Cristina, C., Vela, J., Gonzalez Iglesias, A., Libertun, C., Diaz-Torga, G., Becu-Villalobos, D., Angiotensin and calcium signaling in the pituitary and hypothalamus (2002) Cell Mol Neurobiol, 22, pp. 315-333
  • Summers, C., Tang, W., Zelezna, B., Raizada, M.K., Angiotensin II receptor subtypes are coupled with distinct signal transduction mechanisms in neurons and astrocytes from rat brain (1991) Proc Natl Acad Sci USA, 88, pp. 7567-7571
  • Takahashi, T., Kawahara, Y., Okuda, M., Ueno, H., Takeshita, A., Yokoyama, M., Angiotensin II stimulates mitogen-activated protein kinases and protein synthesis by a Ras-independent pathway in vascular smooth muscle cells (1997) J Biol Chem, 272, pp. 16018-16022
  • Takeda-Matsubara, Y., Nakagami, H., Iwai, M., Cui, T.X., Shiuchi, T., Akishita, M., Nahmias, C., Ito, M., Estrogen activates phosphatases and antagonizes growth-promoting effect of angiotensin II (2002) Hypertension, 39, pp. 41-45
  • Terada, Y., Tomita, K., Homma, M.K., Nonoguchi, H., Yang, T., Yamada, T., Yuasa, Y., Marumo, F., Sequential activation of MAP kinase cascade by angiotensin II in opossum kidney cells (1995) Kidney Int, 48, pp. 1801-1809
  • Tian, Y., Smith, R.D., Balla, T., Catt, K.J., Angiotensin II activates mitogen-activated protein kinase via protein kinase C and Ras/Raf-1 kinase in bovine adrenal glomerulosa cells (1998) Endocrinology, 139, pp. 1801-1809
  • Van Biesen, T., Luttrell, L.M., Hawes, B.E., Lefkowitz, R.J., Mitogenic signaling via G protein-coupled receptors (1996) Endocr Rev, 17, pp. 698-714
  • Wen, Y., Nadler, J.L., Gonzales, N., Scott, S., Clauser, E., Natarajan, R., Mechanism of ANG II-induced mitogenic responses: Role of 12-lipoxygenase and biphasic MAP kinase (1996) Am J Physiol Cell Physiol, 271, pp. C1212-C1220
  • Yang, H., Luc, D., Vinson, G.P., Raizada, M.K., Involvement of MAP kinase in angiotensin II-induced phosphorylation and intracellular targeting of neuronal AT1 receptors (1997) J Neurosci, 17, pp. 1660-1669
  • Zou, Y., Komuro, I., Yamazaki, T., Aikawa, R., Kudoh, S., Shiojima, I., Hiroi, Y., Yazaki, Y., Protein kinase C, but not tyrosihe kinases or Ras, plays a critical role in angiotensin II-induced activation of Raf-1 kinase and extracellular signal-regulated protein kinases in cardiac myocytes (1996) J Biol Chem, 271, pp. 33592-33597

Citas:

---------- APA ----------
Suárez, C., Díaz-Torga, G., Gonzalez-Iglesias, A., Vela, J., Mladovan, A., Baldi, A. & Becu-Villalobos, D. (2003) . Angiotensin II phosphorylation of extracellular signal-regulated kinases in rat anterior pituitary cells. American Journal of Physiology - Endocrinology and Metabolism, 285(3 48-3), E645-E653.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01931849_v285_n348-3_pE645_Suarez [ ]
---------- CHICAGO ----------
Suárez, C., Díaz-Torga, G., Gonzalez-Iglesias, A., Vela, J., Mladovan, A., Baldi, A., et al. "Angiotensin II phosphorylation of extracellular signal-regulated kinases in rat anterior pituitary cells" . American Journal of Physiology - Endocrinology and Metabolism 285, no. 3 48-3 (2003) : E645-E653.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01931849_v285_n348-3_pE645_Suarez [ ]
---------- MLA ----------
Suárez, C., Díaz-Torga, G., Gonzalez-Iglesias, A., Vela, J., Mladovan, A., Baldi, A., et al. "Angiotensin II phosphorylation of extracellular signal-regulated kinases in rat anterior pituitary cells" . American Journal of Physiology - Endocrinology and Metabolism, vol. 285, no. 3 48-3, 2003, pp. E645-E653.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01931849_v285_n348-3_pE645_Suarez [ ]
---------- VANCOUVER ----------
Suárez, C., Díaz-Torga, G., Gonzalez-Iglesias, A., Vela, J., Mladovan, A., Baldi, A., et al. Angiotensin II phosphorylation of extracellular signal-regulated kinases in rat anterior pituitary cells. Am. J. Physiol. Endocrinol. Metab. 2003;285(3 48-3):E645-E653.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01931849_v285_n348-3_pE645_Suarez [ ]