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Abstract:

The influences of arachidonic acid (AA) and of inhibitors of lipoxygenases (eicosetetraynoic acid-ETYA- and nordihydrogusiaretic acid -NDGA-) on platelet aggregation evoked by collagen or adenosinediphosphate (ADP) as well as platelet adhesiveness to collagen f platelet-rich-plasma (PRP) from aspirin-treated patients were explored. ETYA or NDGA (10-8 and 10-7 M) clearly diminished the per cent aggregation evoked by collagen or ADP and delayed its onset. On the other hand AA (0.2 mM) enhanced the aggregation and shortened the leg phase evoked by collagen at 1.2 and 2.6 ug/ml, but not at 5.2 ug/ml. Platelet-collagen adhesion of PRP was significantly reduced by ETYA or NDGA (10-7 M) and augmented by AA (2 mM). The results strongly suggest that lipoxygenese products of arachidonate metabolism play an important role in promoting the mechanisms) underlying human platelet aggregation and adhesiveness. © 1983.

Registro:

Documento: Artículo
Título:Lipoxygenase inhibitors alter aggregation and adhesiveness of human blood platelets from aspirin-treated patients
Autor:Gimeno, M.F.; Shattner, M.A.; Borda, E.; Gimeno, A.L.; Lazzari, M.A.
Filiación:Centro de Estudios Farmscológicos y de Principios Naturales (CEFAPRIN); Consejo Nacional de Investigeciones Cientificas y Técnicas de la Republics Argentina (CONICET) and Instituto de Investigaciones Hematológicas, Academia Necional de Medicine. Serrano 665/669, (1414) Buenos Aires, Argentina
Palabras clave:5,8,11,14 icosatetraynoic acid; acetylsalicylic acid; adenosine diphosphate; alcohol; arachidonic acid; collagen; dimethyl sulfoxide; nordihydroguaiaretic acid; adhesion; blood and hemopoietic system; cardiovascular system; controlled study; drug mechanism; drug sensitivity; human; human cell; patient; therapy; thrombocyte aggregation; thrombosis; 5,8,11,14-Eicosatetraynoic Acid; Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Catechols; Collagen; Humans; Lipoxygenase Inhibitors; Nordihydroguaiaretic Acid; Platelet Adhesiveness; Platelet Aggregation
Año:1983
Volumen:11
Número:1
Página de inicio:109
Página de fin:119
DOI: http://dx.doi.org/10.1016/0262-1746(83)90115-4
Título revista:Prostaglandins, Leukotrienes and Medicine
Título revista abreviado:Prostaglandins Leukotrienes Med.
ISSN:02621746
CODEN:PLMED
CAS:5,8,11,14 icosatetraynoic acid, 1191-85-1; acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; adenosine diphosphate, 20398-34-9, 58-64-0; alcohol, 64-17-5; arachidonic acid, 506-32-1, 6610-25-9, 7771-44-0; collagen, 9007-34-5; dimethyl sulfoxide, 67-68-5; nordihydroguaiaretic acid, 500-38-9; 5,8,11,14-Eicosatetraynoic Acid, 1191-85-1; Adenosine Diphosphate, 58-64-0; Arachidonic Acid, 506-32-1; Arachidonic Acids; Aspirin, 50-78-2; Catechols; Collagen, 9007-34-5; Lipoxygenase Inhibitors; Nordihydroguaiaretic Acid, 500-38-9
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02621746_v11_n1_p109_Gimeno

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Citas:

---------- APA ----------
Gimeno, M.F., Shattner, M.A., Borda, E., Gimeno, A.L. & Lazzari, M.A. (1983) . Lipoxygenase inhibitors alter aggregation and adhesiveness of human blood platelets from aspirin-treated patients. Prostaglandins, Leukotrienes and Medicine, 11(1), 109-119.
http://dx.doi.org/10.1016/0262-1746(83)90115-4
---------- CHICAGO ----------
Gimeno, M.F., Shattner, M.A., Borda, E., Gimeno, A.L., Lazzari, M.A. "Lipoxygenase inhibitors alter aggregation and adhesiveness of human blood platelets from aspirin-treated patients" . Prostaglandins, Leukotrienes and Medicine 11, no. 1 (1983) : 109-119.
http://dx.doi.org/10.1016/0262-1746(83)90115-4
---------- MLA ----------
Gimeno, M.F., Shattner, M.A., Borda, E., Gimeno, A.L., Lazzari, M.A. "Lipoxygenase inhibitors alter aggregation and adhesiveness of human blood platelets from aspirin-treated patients" . Prostaglandins, Leukotrienes and Medicine, vol. 11, no. 1, 1983, pp. 109-119.
http://dx.doi.org/10.1016/0262-1746(83)90115-4
---------- VANCOUVER ----------
Gimeno, M.F., Shattner, M.A., Borda, E., Gimeno, A.L., Lazzari, M.A. Lipoxygenase inhibitors alter aggregation and adhesiveness of human blood platelets from aspirin-treated patients. Prostaglandins Leukotrienes Med. 1983;11(1):109-119.
http://dx.doi.org/10.1016/0262-1746(83)90115-4