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Noaín, D.; Pérez-Millán, M.I.; Bello, E.P.; Luque, G.M.; Cordero, R.C.; Gelman, D.M.; Peper, M.; Tornadu, I.G.; Low, M.J.; Becú-Villalobos, D.; Rubinstein, M. "Central dopamine D2 receptors regulate growth-hormone- dependent body growth and pheromone signaling to conspecific males" (2013) Journal of Neuroscience. 33(13):5834-5842
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Abstract:

Competition between adult males for limited resources such as food and receptive females is shaped by the male pattern of pituitary growth hormone (GH) secretion that determines body size and the production of urinary pheromones involved in male-to-male aggression. In the brain, dopamine (DA) provides incentive salience to stimuli that predict the availability of food and sexual partners. Although the importance of the GH axis and central DA neurotransmission in social dominance and fitness is clearly appreciated, the two systems have always been studied unconnectedly. Here we conducted a cell-specific genetic dissection study in conditional mutant mice that selectively lack DA D2 receptors (D2R) from pituitary lactotropes (lacDrd2KO) or neurons (neuroDrd2KO). Whereas lacDrd2KO mice developed a normal GH axis, neuroDrd2KO mice displayed fewer somatotropes; reduced hypothalamic Ghrh expression, pituitary GH content, and serum IGF-I levels; and exhibited reduced body size and weight. As a consequence of a GH axis deficit, neuroDrd2KO adult males excreted low levels of major urinary proteins and their urine failed to promote aggression and territorial behavior in control male challengers, in contrast to the urine taken from control adult males. These findings reveal that central D2Rs mediate a neuroendocrineexocrine cascade that controls the maturation of the GH axis and downstream signals that are critical for fitness, social dominance, and competition between adult males. © 2013 the authors.

Registro:

Documento: Artículo
Título:Central dopamine D2 receptors regulate growth-hormone- dependent body growth and pheromone signaling to conspecific males
Autor:Noaín, D.; Pérez-Millán, M.I.; Bello, E.P.; Luque, G.M.; Cordero, R.C.; Gelman, D.M.; Peper, M.; Tornadu, I.G.; Low, M.J.; Becú-Villalobos, D.; Rubinstein, M.
Filiación:Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, C1428ADN Buenos Aires, Argentina
Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, C1428ADN Buenos Aires, Argentina
Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48105, United States
Universidad de Buenos Aires, C1428EGA Buenos Aires, Argentina
Palabras clave:dopamine; dopamine 2 receptor; growth hormone; pheromone; prolactin; somatomedin C receptor; animal experiment; animal tissue; article; autoradiography; behavior; body growth; body size; body weight; controlled study; female; fitness; food intake; immunofluorescence test; in situ hybridization; male; motor unit potential; mouse; neurotransmission; nonhuman; priority journal; radioimmunoassay; real time polymerase chain reaction; signal transduction; social dominance; Analysis of Variance; Animals; Benzamides; Body Size; Body Weight; Case-Control Studies; Catatonia; Dopamine Antagonists; Eating; Female; Growth Hormone; Haloperidol; Insulin-Like Growth Factor I; Intermediate Filament Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Oligodeoxyribonucleotides, Antisense; Pheromones; Pituitary Gland; Prolactin; Protein Binding; Proteins; Radioimmunoassay; Receptors, Dopamine D2; Social Dominance; Territoriality; Tritium
Año:2013
Volumen:33
Número:13
Página de inicio:5834
Página de fin:5842
DOI: http://dx.doi.org/10.1523/JNEUROSCI.5673-12.2013
Título revista:Journal of Neuroscience
Título revista abreviado:J. Neurosci.
ISSN:02706474
CODEN:JNRSD
CAS:dopamine, 51-61-6, 62-31-7; growth hormone, 36992-73-1, 37267-05-3, 66419-50-9, 9002-72-6; prolactin, 12585-34-1, 50647-00-2, 9002-62-4; Benzamides; Dopamine Antagonists; Growth Hormone, 9002-72-6; Haloperidol, 52-86-8; Insulin-Like Growth Factor I, 67763-96-6; Intermediate Filament Proteins; Nerve Tissue Proteins; Oligodeoxyribonucleotides, Antisense; Pheromones; Prolactin, 9002-62-4; Proteins; Receptors, Dopamine D2; Tritium, 10028-17-8; major urinary proteins; nemonapride, 70325-83-6; nestin
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02706474_v33_n13_p5834_Noain

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Citas:

---------- APA ----------
Noaín, D., Pérez-Millán, M.I., Bello, E.P., Luque, G.M., Cordero, R.C., Gelman, D.M., Peper, M.,..., Rubinstein, M. (2013) . Central dopamine D2 receptors regulate growth-hormone- dependent body growth and pheromone signaling to conspecific males. Journal of Neuroscience, 33(13), 5834-5842.
http://dx.doi.org/10.1523/JNEUROSCI.5673-12.2013
---------- CHICAGO ----------
Noaín, D., Pérez-Millán, M.I., Bello, E.P., Luque, G.M., Cordero, R.C., Gelman, D.M., et al. "Central dopamine D2 receptors regulate growth-hormone- dependent body growth and pheromone signaling to conspecific males" . Journal of Neuroscience 33, no. 13 (2013) : 5834-5842.
http://dx.doi.org/10.1523/JNEUROSCI.5673-12.2013
---------- MLA ----------
Noaín, D., Pérez-Millán, M.I., Bello, E.P., Luque, G.M., Cordero, R.C., Gelman, D.M., et al. "Central dopamine D2 receptors regulate growth-hormone- dependent body growth and pheromone signaling to conspecific males" . Journal of Neuroscience, vol. 33, no. 13, 2013, pp. 5834-5842.
http://dx.doi.org/10.1523/JNEUROSCI.5673-12.2013
---------- VANCOUVER ----------
Noaín, D., Pérez-Millán, M.I., Bello, E.P., Luque, G.M., Cordero, R.C., Gelman, D.M., et al. Central dopamine D2 receptors regulate growth-hormone- dependent body growth and pheromone signaling to conspecific males. J. Neurosci. 2013;33(13):5834-5842.
http://dx.doi.org/10.1523/JNEUROSCI.5673-12.2013