Abstract:
The action of luteinizing hormone on topoisomerase I activity from rat Leydig cells was studied. Stimulation of the enzyme was observed after long-term (24 and 48 h) gonadotrophin treatment in in vivo experiments. No change could be detected for shorter times than 12 h using two different experimental approaches. Topoisomerase I was stimulated by cAMP in a whole cell extract in a phosphorylation-dependent manner. These results suggest that topoisomerase I could be a target for nuclear events induced by peptide hormone action. © 1987.
Registro:
Documento: |
Artículo
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Título: | DNA topoisomerase I from Leydig cells is modulated by luteinizing hormone and cyclic adenosine monophosphate |
Autor: | Crespi, M.D.; Radicella, J.P.; Baldi, A.; Charreau, E.H.; Calvo, J.C. |
Filiación: | Institute de Biologia y Medicina Experimental, Obligado 2490, 1428 Buenos Aires, Argentina Departamenlo de Quimica Biologien, Facultad de Ciencias Exaclas y Naturelles, UBA, Buenos Aires, Argentina
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Palabras clave: | DNA topoisomerase I; Leydig cell; Nuclear effect; Peptide hormone; cyclic amp; dna; dna topoisomerase; luteinizing hormone; peptide; animal cell; leydig cell; male genital system; nonhuman; nucleus; priority journal; rat; Animals; Carrier Proteins; Cyclic AMP; DNA Topoisomerases, Type I; Gonadotropins; Intracellular Signaling Peptides and Proteins; Leydig Cells; Luteinizing Hormone; Male; Rats; Rats, Inbred Strains; Testosterone |
Año: | 1987
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Volumen: | 53
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Número: | 3
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Página de inicio: | 221
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Página de fin: | 226
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DOI: |
http://dx.doi.org/10.1016/0303-7207(87)90177-8 |
Título revista: | Molecular and Cellular Endocrinology
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Título revista abreviado: | Mol. Cell. Endocrinol.
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ISSN: | 03037207
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CODEN: | MCEND
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CAS: | DNA, 9007-49-2; DNA topoisomerase, 80449-01-0; cyclic AMP, 60-92-4; luteinizing hormone, 39341-83-8, 9002-67-9; Carrier Proteins; Cyclic AMP, 60-92-4; DNA Topoisomerases, Type I, 5.99.1.2; Gonadotropins; Intracellular Signaling Peptides and Proteins; Luteinizing Hormone, 9002-67-9; Testosterone, 58-22-0; protein kinase modulator
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03037207_v53_n3_p221_Crespi |
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Citas:
---------- APA ----------
Crespi, M.D., Radicella, J.P., Baldi, A., Charreau, E.H. & Calvo, J.C.
(1987)
. DNA topoisomerase I from Leydig cells is modulated by luteinizing hormone and cyclic adenosine monophosphate. Molecular and Cellular Endocrinology, 53(3), 221-226.
http://dx.doi.org/10.1016/0303-7207(87)90177-8---------- CHICAGO ----------
Crespi, M.D., Radicella, J.P., Baldi, A., Charreau, E.H., Calvo, J.C.
"DNA topoisomerase I from Leydig cells is modulated by luteinizing hormone and cyclic adenosine monophosphate"
. Molecular and Cellular Endocrinology 53, no. 3
(1987) : 221-226.
http://dx.doi.org/10.1016/0303-7207(87)90177-8---------- MLA ----------
Crespi, M.D., Radicella, J.P., Baldi, A., Charreau, E.H., Calvo, J.C.
"DNA topoisomerase I from Leydig cells is modulated by luteinizing hormone and cyclic adenosine monophosphate"
. Molecular and Cellular Endocrinology, vol. 53, no. 3, 1987, pp. 221-226.
http://dx.doi.org/10.1016/0303-7207(87)90177-8---------- VANCOUVER ----------
Crespi, M.D., Radicella, J.P., Baldi, A., Charreau, E.H., Calvo, J.C. DNA topoisomerase I from Leydig cells is modulated by luteinizing hormone and cyclic adenosine monophosphate. Mol. Cell. Endocrinol. 1987;53(3):221-226.
http://dx.doi.org/10.1016/0303-7207(87)90177-8