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Abstract:

Rat pineal glands incubated in vitro with 10 or 100 μM norepinephrine (NE) released 51% and 415% more prostaglandin E2 (PGE2) to the medium than in the absence of NE. Phentolamine (10 μM) prevented fully the effect of NE at both concentrations, whereas propranolol failed to affect it significantly. After superior cervical ganglionectomy (SCGx), NE-induced PGE2 release was significantly higher than in sham-operated controls - an effect also blocked by phentolamine but not by oropranolol. These results suggest that NE releases PGE2 in rat pineals via α-adrenoceptors, acting at a post-synaptic site, and that SCGx induces α-adrenergic supersensitivity in the pinealocytes. © 1982.

Registro:

Documento: Artículo
Título:Involvement of α-adrenoceptors in norepinephrine-induced prostaglandin E2 release by rat pineal gland in vitro
Autor:Ritta, M.N.; Cardinali, D.P.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Serrano 665/669, 1414 Buenos Aires, Argentina
Palabras clave:adrenergic supersensitivity; norepinephrine; pineal gland; prostaglandins; superior cervical ganglion; α-adrenoceptors; alpha adrenergic receptor; noradrenalin; phentolamine; propranolol; prostaglandin; prostaglandin e2; animal experiment; endocrine system; in vitro study; pineal body; rat; Adrenergic Fibers; Animal; Denervation; Dinoprostone; Dose-Response Relationship, Drug; Ganglia, Sympathetic; Male; Norepinephrine; Pineal Gland; Prostaglandins E; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Support, Non-U.S. Gov't
Año:1982
Volumen:31
Número:3
Página de inicio:307
Página de fin:311
DOI: http://dx.doi.org/10.1016/0304-3940(82)90038-6
Título revista:Neuroscience Letters
Título revista abreviado:Neurosci. Lett.
ISSN:03043940
CODEN:NELED
CAS:noradrenalin, 1407-84-7, 51-41-2; phentolamine, 50-60-2, 73-05-2; propranolol, 13013-17-7, 318-98-9, 3506-09-0, 4199-09-1, 525-66-6; prostaglandin E2, 363-24-6; Dinoprostone, 363-24-6; Norepinephrine, 51-41-2; Prostaglandins E; Receptors, Adrenergic; Receptors, Adrenergic, alpha
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03043940_v31_n3_p307_Ritta

Referencias:

  • Alphs, Heller, Lovenberg, Adrenergic regulation of the reduction in acetyl coenzymelarylamine N-acetyltransferase activity in the rat pineal (1980) J. Neurochem., 34, pp. 83-90
  • Cardinali, Ritta, Fuentes, Gimeno, Gimeno, Prostaglandin E release by rat medial basal hypothalamus in vitro. Inhibition by melatonin at submicromolar concentrations (1980) Europ. J. Pharmacol., 67, pp. 151-153
  • Cardinali, D.P., Ritta, M.N., Pereyra, E.N. and González Solveyra, C., Role of prostaglandins in rat pineal neuroeffector junction. Changes in melatonin and norepinephrine release in vitro, Endocrinology, in press; Cardinali, Ritta, Speziale, Gimeno, Release and specific binding of protaglandins in bovine pineal gland (1979) Prostaglandins, 18, pp. 577-589
  • Deguchi, Axelrod, Induction and superinduction of serotonin N-acetyltransferase by adrenergic drugs and denervation in rat pineal organ (1972) Proc. nat Acad. Sci. U.S.A., 69, pp. 2208-2211
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  • Klein, Auerbach, Namboodiri, Wheler, Indole metabolism in the mammalian pineal gland (1981) The Pineal Gland, Vol. 1, Anatomy and Biochemistry, pp. 199-228. , R.J. Reiter, CRC Press, Boca Raton
  • Klein, Weller, Adrenergic-adenosine-3′,5′-monophosphate regulation of seroton n-N-acetyltransferase activity and the temporal relationship of serotonin-N-acetyltransferase activity to synthesis of 3H-N-acetylserotonin and 3H-melatonin in the cultured rat pineal gland (1973) J. Pharmacol. exp. Ther., 189, pp. 516-527
  • McLouf, Andieu, Oray, Validity of PGE radioimmunoassay by using PGE antisera with differential binding parameters (1975) FEBS Lett., 56, pp. 273-279
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  • Ojeda, Negro-Vilar, McCann, Evidence for involvement of α-adrenergic receptors in norepinephrine-induced prostaglandin E2 and luteinizing hormone-releasing hormone release from the median eminence (1982) Endocrinology, 110, pp. 409-412
  • Pelayo, Dubocovich, Langer, Regulation of noradrenaline release in the rat pineal gland through a negative feedback mechanism mediated by presynaptic α-adrenoceptors (1977) Europ. J. Pharmacol., 45, pp. 317-318
  • Ritta, Cardinali, Effects of indomethacin treatment on monoamine metabolism and melatonin synthesis in rat pineal gland (1980) Hormone Res., 12, pp. 305-312
  • Ritta, Cardinali, Prostaglandin E2 increases adenosine-3′,5′-monophosphate concentration and binding site occupancy, and stimulates serotonin-N-acetyltransferase activity in rat pineal glands in vitro (1981) Mol. Cell. Endocr., 23, pp. 151-159
  • Smith, Eichberg, Hauser, Postsynaptic localization of the alpha receptor-mediated stimulation of phosphatidylinositol turnover in pineal gland (1979) Life Sci., 24, pp. 2179-2184
  • Tukey, (1953) The Problem of Multiple Comparisons, , Princeton University Press, Princeton
  • Vacas, Lowenstein, Cardinali, Dihydroergocryptine binding sites in bovine and rat pineal glands (1980) J. Auton. Nerv. Syst., 2, pp. 305-313

Citas:

---------- APA ----------
Ritta, M.N. & Cardinali, D.P. (1982) . Involvement of α-adrenoceptors in norepinephrine-induced prostaglandin E2 release by rat pineal gland in vitro. Neuroscience Letters, 31(3), 307-311.
http://dx.doi.org/10.1016/0304-3940(82)90038-6
---------- CHICAGO ----------
Ritta, M.N., Cardinali, D.P. "Involvement of α-adrenoceptors in norepinephrine-induced prostaglandin E2 release by rat pineal gland in vitro" . Neuroscience Letters 31, no. 3 (1982) : 307-311.
http://dx.doi.org/10.1016/0304-3940(82)90038-6
---------- MLA ----------
Ritta, M.N., Cardinali, D.P. "Involvement of α-adrenoceptors in norepinephrine-induced prostaglandin E2 release by rat pineal gland in vitro" . Neuroscience Letters, vol. 31, no. 3, 1982, pp. 307-311.
http://dx.doi.org/10.1016/0304-3940(82)90038-6
---------- VANCOUVER ----------
Ritta, M.N., Cardinali, D.P. Involvement of α-adrenoceptors in norepinephrine-induced prostaglandin E2 release by rat pineal gland in vitro. Neurosci. Lett. 1982;31(3):307-311.
http://dx.doi.org/10.1016/0304-3940(82)90038-6